dutasteride and skin question

[Dogs3]

is there any evidence that by supressing dht type 1 that dutasteride has any other effect on your skin besides maybe making it less oily/more dry? and to what degree does this even happen?

 

[Bryan]

I have yet to see any published study showing that dutasteride has any effect on sebum production.

 

[Dogs3]

hey Bryan, thanks for the reply. But could that simply mean they no one has bothered to investigate the duts effect on sebum production. Or more likely that an effect or correlation may not significantly exist?

 

[Bryan]

That's a good question, and I'm not sure what the correct answer is. Theoretically, one would expect dutasteride to be able to reduce sebum; but considering how even the standard approved dose of 1 Avodart per day only inhibits the type 1 enzyme by around 50% or so at steady-state (maybe a little more than that), it may not be all that good at doing it. That's because sebum production in men is apparently already "maxed-out", so you might have to reduce the DHT in sebaceous glands even more than what Avodart is capable of doing, just to get a noticeable effect.

Or maybe it's just that nobody has bothered to test it for that, which doesn't seem all that implausible to me. As we all know, dutasteride is a very powerful drug, and I can see that most doctors would hesitate to have to give it to test-subjects for three months or longer just to get blood-levels up high enough to where it _might_ be able to reduce sebum noticeably.

 

[Andrea]

On Avodart my sebum is DRASTICALLY reduced... I have an effect simil Accutane which I tried when I was teenagers.

Maybe depends on expression of the Enzyme 5AR type 1 that has a different expression for everyone...

Bye

Andrea

 

[Dogs3]

so Andrea, are you saying dutasteride is doing good things for your skin then by reducing sebum? Or not much of a change or what?

 

[Andrea]

Yes, my skin is very beautifoul with Duta (zero acne) but my hair is too dry...

 

[Dogs3]

cool, sounds good...id imagine conditioner might help the hair then also

 

[abcdefg]

really testosterone and other hormones could come into play in sebum production besides just dht.

 

[markelbentley]

Andrea,

How long have you been on dutasteride? I noticed some very positive things for my skin when i initially started dutasteride, but then things went to normal. Just curious if you are having a sustained effect.

 

[Andrea]

Hi,
I'm on Dutasteride since January 2007 and at first my skin was totally dry and clean (probably too dry), now I have a good situation (balaced skin) and my acne is completely disappeared.
Even on finasteride I noticed a decrease in sebum production but with dutasteride is more noticeable.
Bye

 

[Andrea]

On dutasteride I also noticed a great decrease in sweat expecially on the scalp.
Sorry but I don't know how edit my message.
Bye

 

[Renegade]

There is no question that dutasteride cleared up my acne (night and day difference). And it did so within a relatively short period of time. The difference was so stark that I have always wondered why I saw so few posts acknowledging this effect. It seemed like I saw more posts claiming an increase in acne from it.

finasteride on the otherhand, gave me wicked increased acne (even on back, where I had never experienced zits before). Again, such a stark difference, there is no doubt in my mind that it was caused by the finasteride.

Sidenote: As for dutasteride's effectiveness in growing more hair, that's a different story!

 

[Dogs3]

i dont know ive seen any difference one way or the other after a month on dutasteride, if anything, my skin is a bit clearer but its hard to say if thats the dutasteride working...

Renegade, how has the dutasteride worked for your hair?