https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434747/
Results:
A significant number of subjects (68.4%) were taking less than half of the recommended daily allowance of proteins and faced problems like hair fall, acne, pigmentation, vitiligo, hirsutism, melasma, and premature aging.
Subjects missing breakfast were found to have hypothyroidism, diffuse hairfall, autoimmune disorders like vitiligo, lichen planus, and alopecia areata. Histopathological images from submental area showed loose and fragmented collagen in high carbohydrate group in comparison to high protein group where thick, uniformly stained collagen bundles were found in dermis.
Histopathology of scalp tissue showed chronic perifollicular inflammatory infiltrate and fibrosis in high carbohydrate group which was absent in histopathology specimen of high protein group.
Patients taking early and nutrient-rich breakfast had higher mean protein intakes and less severe skin and hair problems suggesting a role of circadian rhythm as well.
About 90% of Androgenetic Alopecia patients were deficient in protein, with 55% of them severely deficient (<30 g/day protein). Most of FPB patients (90.90%) and three-fourths (75%) of Telogen Effluvium patients were severely deficient [Chart 1].
Our scalp biopsies endorse the finding of hair follicle destruction with perifollicular inflammation and fibrosis in low protein group (clinically carbohydrate facies) [Figure 4] while high protein group (clinically balanced facies) showed normal follicular structure [Figure 1]. Since hair is entirely protein by structure, it may be hypothesized that hair follicle fibrosis and destruction may be body's conscious decision of self-destruction to conserve proteins for more active and vital tissues like muscles. Authors suggest this phenomenon as “Hypothesis of conscious selective self-destruction and non-renewal” to maintain more important structures and functions.
The gross protein content of skin is around 22% and collagen is the most abundant protein in human body.[8] Hydroxyproline and hydroxylysine required for collagen synthesis are the metabolic dead end of proline and lysine, hence to maintain maximum physicochemical performance, “fresh” proline and lysine should be inserted in the newly synthesized collagen propeptide.[3] From these facts, stems a corollary that adequate amino acid intake to supply substrate and vitamin C as a cofactor for prolyl and lysyl hydroxylase is essential for maintaining existing collagen framework as well as neocollagenesis.[9]
All our patients showing aging were deficient in protein intakes, resulting in a compromise in collagen and elastin synthesis and efficiency of enzymes like matrixmetalloproteinases (MMPs) which help in degradation of old proteins.[9]
Results:
A significant number of subjects (68.4%) were taking less than half of the recommended daily allowance of proteins and faced problems like hair fall, acne, pigmentation, vitiligo, hirsutism, melasma, and premature aging.
Subjects missing breakfast were found to have hypothyroidism, diffuse hairfall, autoimmune disorders like vitiligo, lichen planus, and alopecia areata. Histopathological images from submental area showed loose and fragmented collagen in high carbohydrate group in comparison to high protein group where thick, uniformly stained collagen bundles were found in dermis.
Histopathology of scalp tissue showed chronic perifollicular inflammatory infiltrate and fibrosis in high carbohydrate group which was absent in histopathology specimen of high protein group.
Patients taking early and nutrient-rich breakfast had higher mean protein intakes and less severe skin and hair problems suggesting a role of circadian rhythm as well.
About 90% of Androgenetic Alopecia patients were deficient in protein, with 55% of them severely deficient (<30 g/day protein). Most of FPB patients (90.90%) and three-fourths (75%) of Telogen Effluvium patients were severely deficient [Chart 1].
Our scalp biopsies endorse the finding of hair follicle destruction with perifollicular inflammation and fibrosis in low protein group (clinically carbohydrate facies) [Figure 4] while high protein group (clinically balanced facies) showed normal follicular structure [Figure 1]. Since hair is entirely protein by structure, it may be hypothesized that hair follicle fibrosis and destruction may be body's conscious decision of self-destruction to conserve proteins for more active and vital tissues like muscles. Authors suggest this phenomenon as “Hypothesis of conscious selective self-destruction and non-renewal” to maintain more important structures and functions.
The gross protein content of skin is around 22% and collagen is the most abundant protein in human body.[8] Hydroxyproline and hydroxylysine required for collagen synthesis are the metabolic dead end of proline and lysine, hence to maintain maximum physicochemical performance, “fresh” proline and lysine should be inserted in the newly synthesized collagen propeptide.[3] From these facts, stems a corollary that adequate amino acid intake to supply substrate and vitamin C as a cofactor for prolyl and lysyl hydroxylase is essential for maintaining existing collagen framework as well as neocollagenesis.[9]
All our patients showing aging were deficient in protein intakes, resulting in a compromise in collagen and elastin synthesis and efficiency of enzymes like matrixmetalloproteinases (MMPs) which help in degradation of old proteins.[9]
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