OverMachoGrande
Senior Member
- Reaction score
- 43
Here I present several articles stating the relationship between Diabetes and Hair Loss, followed by several articles in relation to Aloe Vera (THE anti-inflammatory plant), and it's relation to Diabetes. There are many more as well, and on Cinnamon relation to Diabetes, which I did not cite here, as I thought this would be sufficient.
The purpose of this form is to help understand and correlate Diabetes with Hair loss, giving us a better idea on what and how we can battle it, especially using natural compounds.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Curr Opin Endocrinol Diabetes Obes. 2007 Jun;14(3):226-34.
Androgen deficiency, diabetes, and the metabolic syndrome in men.
Kalyani RR, Dobs AS.
Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
PURPOSE OF REVIEW: The burden of androgen deficiency in men with diabetes and the metabolic syndrome has become increasingly apparent in population-based studies. This article focuses on the mechanisms underlying the interdependent relationship between these conditions. RECENT FINDINGS: Various definitions of hypogonadism, the metabolic syndrome and diabetes have been proposed and are used in the literature. Cross-sectional studies have found that between 20 and 64% of men with diabetes have hypogonadism, with higher prevalence rates found in the elderly. Hypogonadism can be a risk factor for the development of diabetes and the metabolic syndrome through various mechanisms including changes in body composition; androgen receptor polymorphisms; glucose transport; and reduced antioxidant effect. Conversely, diabetes and the metabolic syndrome can be risk factors for hypogonadism through some similar but mostly distinct mechanisms, such as increased body weight; decreased sex hormone binding globulin levels; suppression of gonadotrophin release or Leydig cell testosterone production; cytokine-mediated inhibition of testicular steroid production; and increased aromatase activity contributing to relative estrogen excess. SUMMARY: The relationship between diabetes, the metabolic syndrome and androgen deficiency is complex. Testosterone supplementation, by either oral or intramuscular routes and through exogenous or endogenous delivery, has a promising role in this population although further clinical trials are needed.
Clin Endocrinol (Oxf). 2009 Oct;71(4):494-9.
Androgenetic alopecia and insulin resistance in young men.
González-González JG, Mancillas-Adame LG, Fernández-Reyes M, Gómez-Flores M, Lavalle-González FJ, Ocampo-Candiani J, Villarreal-Pérez JZ.
Servicio de Endocrinologia, Dr Jose Eleuterio Gonzalez University Hospital, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Ave. Madero y Gonzalitos S/N, Monterrey, Mexico. jgonzalezg@fm.uanl.mx
BACKGROUND: Epidemiological studies have associated androgenetic alopecia (Androgenetic Alopecia) with severe young-age coronary artery disease and hypertension, and linked it to insulin resistance. We carried out a case-control study in age- and weight-matched young males to study the link between Androgenetic Alopecia and insulin resistance using the homeostasis model assessment of insulin resistance (HOMA-IR) index or metabolic syndrome clinical manifestations. METHODS: Eighty young males, 18-35 years old, with Androgenetic Alopecia > or = stage III in the Hamilton-Norwood classification, and 80 weight- and age-matched controls were included. Alopecia, glucose, serum insulin, HOMA-IR index, lipid profile and androgen levels, as well as metabolic syndrome criteria, were evaluated. RESULTS: The HOMA-IR index was significantly higher in cases than controls. Nonobese cases had a higher mean diastolic blood pressure and a more frequent family history of Androgenetic Alopecia than nonobese controls. A borderline difference in the HOMA-IR index was found in obese Androgenetic Alopecia cases vs. obese controls [P = 0.055, 95% confidence interval (CI) 2.36-4.20 vs. 1.75-2.73]. Free testosterone values were significantly higher in controls than cases, regardless of body mass index (BMI). A statistically significant additive effect for obesity plus alopecia was found, with significant trends for insulin, the HOMA-IR index, lipids and free testosterone when BMI and alopecia status were used to classify the participants. CONCLUSIONS: Our results support the recommendation for assessing insulin resistance and cardiovascular-related features and disorders in all young males with stage III or higher Androgenetic Alopecia, according to the Hamilton-Norwood classification
PMID: 19094069 [PubMed - indexed for MEDLINE]
Endocr Regul. 2005 Dec;39(4):127-31.
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
Starka L, Duskova M, Cermakova I, Vrbiková J, Hill M.
Institute of Endocrinology, Narodni 8, CZ 116 94 Prague 1, Czech Republic. lstarka@endo.cz
BACKGROUND: Polycystic ovary syndrome (PCOS), the most frequent endocrinopathy in women with estimated prevalence of 5-10 %, is characterised by a hormonal and metabolic imbalance of polygene autosomal trait. The complexity of symptoms and genetic base started up the hypothesis on the existence of male equivalent of PCOS. Precocious loss of hair before 30 years of age was suggested as one of the male symptoms of this syndrome. OBJECTIVES: The aim was to confirm the association of lower levels of follicle stimulating hormone (FSH) and sexual hormone binding globulin (SHBG) or higher free androgen index (FAI) in premature balding men with a reduced insulin sensitivity. PATIENTS/METHODS: The study included 30 men with premature hair loss (defined as grade 3 vertex or more on the alopecia classification scale by Hamilton with Norwood modification) starting before 30 years of age. The hormonal values of the investigated group were compared with those regarded as normal reference values obtained in a group of 256 males in the age of 20-40 years during the Czech population study of iodine deficiency. In all men with premature baldness besides hormonal level determinations insulin tolerance test was carried out. RESULTS: The observed group was divided into two subgroups. The first one showed similar hormonal changes as women with PCOS, namely subnormal SHBG, FSH or increased FAI. The other had either no anomalies in steroid spectrum or only lower SHBG. The groups did not differ either in BMI or in age. The group with hormonal profile resembling that of women with PCOS, showed significantly higher insulin resistance than the group without these changes. CONCLUSIONS: The findings are consistent with the hypothesis that at least a part of the men with premature androgenic alopecia could be considered as a male equivalent of the polycystic ovary syndrome of the women. These premature balding men represent a risk group for the development of impaired glucose tolerance or diabetes mellitus type 2.
Now for Aloe Vera,
Phytomedicine. 2009 Sep;16(9):856-63. Epub 2009 Mar 19.
Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus.
Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.
Department of Pharmacy, SahmYook University, Seoul, South Korea.
The effects of processed Aloe vera gel (PAG) on the course of established diet-induced non-insulin-dependent diabetes mellitus (NIDDM) were studied in C57BL/6J mice. NIDDM was induced in C57BL/6J mice by feeding them a high-fat diet. Mice exhibiting diet-induced obesity (DIO) with blood glucose levels above 180mg/dl were selected to examine the antidiabetic effects of PAG. Oral administration of PAG for 8 weeks reduced circulating blood glucose concentrations to a normal level in these DIO mice. In addition, the administration of PAG significantly decreased plasma insulin. The antidiabetic effects of PAG were also confirmed by intraperitoneal glucose tolerance testing. PAG appeared to lower blood glucose levels by decreasing insulin resistance. The administration of PAG also lowered triacylglyceride levels in liver and plasma. Histological examinations of periepididymal fat pad showed that PAG reduced the average size of adipocytes. These results demonstrate that the oral administration of PAG prevents the progression of NIDDM-related symptoms in high-fat diet-fed mice, and suggest that PAG could be useful for treating NIDDM.
Wound Repair Regen. 2008 Nov-Dec;16(6):784-90.
A poly-herbal formulation accelerates normal and impaired diabetic wound healing.
Gupta A, Upadhyay NK, Sawhney RC, Kumar R.
Department of Biochemical Pharmacology, Defence Institute of Physiology and Allied Sciences (DIPAS), Delhi, India. asheesh_gupta2001@yahoo.co.in
In the present study, a poly-herbal formulation (PHF) was prepared by combining the aqueous lyophilized leaf extracts of Hippophae rhamnoides L. and Aloe vera L. and the ethanol rhizome extract of Curcuma longa L., in an optimized ratio (1 : 7 : 1). The efficacy of PHF treatment was studied in normal and impaired diabetic rats using a full-thickness cutaneous wound model. Topical PHF treatment increased cellular proliferation and collagen synthesis at the wound site in normal rats, as evidenced by the significant increase in DNA, total protein, hydroxyproline, and hexosamine contents in comparison with a positive control treated with a povidone-iodine ointment. The histological examinations and matrix metalloproteinases expression also correlated well with the biochemical findings, confirming the efficacy of PHF in normal wounds. In the streptozotocin-induced diabetic rats, PHF treatment increased hydroxyproline and hexosamine content. A faster wound contraction was also observed in PHF-treated normal and diabetic rats. The PHF also promoted angiogenesis as evidenced by an in vitro chick chorioallantoic membrane model and in vivo up-regulated vascular endothelial growth factor expression. The results suggest that PHF possesses significant wound healing potential in both normal as well as chronic diabetic wounds.
Fitoterapia. 2008 Sep;79(6):456-7. Epub 2008 May 27.
Alpha-glucosidase inhibitor from Chinese aloes.
Jong-Anurakkun N, Bhandari MR, Hong G, Kawabata J.
Laboratory of Food Biochemistry, Division of Applied Bioscience,Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. j_nilubon@hotmail.com
Activity-guided fractionation of the methanol extract of Chinese aloes led to the isolation of aloeresin A, which demonstrated significant dose dependent alpha-glucosidase inhibitory activities, with IC(50) values of 11.94 and 2.16 mM, against rat intestinal sucrase and maltase, respectively.
Am J Chin Med. 2007;35(6):1037-46.
Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice.
Pérez YY, Jiménez-Ferrer E, Zamilpa A, Hernández-Valencia M, Alarcón-Aguilar FJ, Tortoriello J, Román-Ramos R.
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México. perezyy@yahoo.com
Insulin resistance, which precedes type 2 diabetes mellitus (T2DM), is a widespread pathology associated with the metabolic syndrome, myocardial ischemia, and hypertension. Finding an adequate treatment for this pathology is an important goal in medicine. The purpose of the present research was to investigate the effect of an extract from Aloe vera gel containing a high concentration of polyphenols on experimentally induced insulin resistance in mice. A polyphenol-rich Aloe vera extract (350 mg/kg) with known concentrations of aloin (181.7 mg/g) and aloe-emodin (3.6 mg/g) was administered orally for a period of 4 weeks to insulin resistant ICR mice. Pioglitazone (50 mg/kg) and bi-distilled water were used as positive and negative controls respectively. Body weight, food intake, and plasma concentrations of insulin and glucose were measured and insulin tolerance tests were performed. The insulin resistance value was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) formula. Results showed that the polyphenol-rich extract from Aloe vera was able to decrease significantly both body weight (p < 0.008) and blood glucose levels (p < 0.005) and to protect animals against unfavorable results on HOMA-IR, which was observed in the negative control group. The highest glucose levels during the insulin tolerance curve test were in the negative control group when compared to the Aloe vera extract and pioglitazone treated mice (p < 0.05). In conclusion, Aloe vera gel could be effective for the control of insulin resistance.
Cent Afr J Med. 2005 Nov-Dec;51(11-12):115-20.
Anti-diabetic activity of Aloe excelsa.
Gundidza M, Masuku S, Humphrey G, Magwa ML.
Department of Pharmacy, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe.
OBJECTIVE: To investigate the effect of Aloe excelsa powder on diabetes. DESIGN: The experiment was carried out in the laboratory on both normal and diabetic rats. Diabetes was induced in the rats by using streptozotocin. Thereafter, blood samples were taken from both the normal and diabetic rats and the sugar levels measured by using the Accutrend Alpha blood glucose monitoring kit. SETTING: The experiment was conducted in the laboratory in the Faculty of Medicine at the University of Zimbabwe. SUBJECTS: A total of 280 male albino rats weighing 250 g on average were used. They were obtained from the Animal House of the Medical School at the University of Zimbabwe. MAIN OUTCOME MEASURES: Reduction in sugar levels. RESULTS: The Aloe excelsa powder produced a dose-dependent reduction in the blood glucose in blood glucose levels. It also compared well with the effect of insulin. CONCLUSION: This study shows that Aloe excelsa has significant activity on glucose levels in rats and this, therefore, confirms the claims by traditional healers that this plant has anti-diabetic effects.
We see here how Aloe Vera can help Insulin resistance and Diabetes, and how Diabetes is connected to male pattern baldness.
The purpose of this form is to help understand and correlate Diabetes with Hair loss, giving us a better idea on what and how we can battle it, especially using natural compounds.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Curr Opin Endocrinol Diabetes Obes. 2007 Jun;14(3):226-34.
Androgen deficiency, diabetes, and the metabolic syndrome in men.
Kalyani RR, Dobs AS.
Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
PURPOSE OF REVIEW: The burden of androgen deficiency in men with diabetes and the metabolic syndrome has become increasingly apparent in population-based studies. This article focuses on the mechanisms underlying the interdependent relationship between these conditions. RECENT FINDINGS: Various definitions of hypogonadism, the metabolic syndrome and diabetes have been proposed and are used in the literature. Cross-sectional studies have found that between 20 and 64% of men with diabetes have hypogonadism, with higher prevalence rates found in the elderly. Hypogonadism can be a risk factor for the development of diabetes and the metabolic syndrome through various mechanisms including changes in body composition; androgen receptor polymorphisms; glucose transport; and reduced antioxidant effect. Conversely, diabetes and the metabolic syndrome can be risk factors for hypogonadism through some similar but mostly distinct mechanisms, such as increased body weight; decreased sex hormone binding globulin levels; suppression of gonadotrophin release or Leydig cell testosterone production; cytokine-mediated inhibition of testicular steroid production; and increased aromatase activity contributing to relative estrogen excess. SUMMARY: The relationship between diabetes, the metabolic syndrome and androgen deficiency is complex. Testosterone supplementation, by either oral or intramuscular routes and through exogenous or endogenous delivery, has a promising role in this population although further clinical trials are needed.
Clin Endocrinol (Oxf). 2009 Oct;71(4):494-9.
Androgenetic alopecia and insulin resistance in young men.
González-González JG, Mancillas-Adame LG, Fernández-Reyes M, Gómez-Flores M, Lavalle-González FJ, Ocampo-Candiani J, Villarreal-Pérez JZ.
Servicio de Endocrinologia, Dr Jose Eleuterio Gonzalez University Hospital, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Ave. Madero y Gonzalitos S/N, Monterrey, Mexico. jgonzalezg@fm.uanl.mx
BACKGROUND: Epidemiological studies have associated androgenetic alopecia (Androgenetic Alopecia) with severe young-age coronary artery disease and hypertension, and linked it to insulin resistance. We carried out a case-control study in age- and weight-matched young males to study the link between Androgenetic Alopecia and insulin resistance using the homeostasis model assessment of insulin resistance (HOMA-IR) index or metabolic syndrome clinical manifestations. METHODS: Eighty young males, 18-35 years old, with Androgenetic Alopecia > or = stage III in the Hamilton-Norwood classification, and 80 weight- and age-matched controls were included. Alopecia, glucose, serum insulin, HOMA-IR index, lipid profile and androgen levels, as well as metabolic syndrome criteria, were evaluated. RESULTS: The HOMA-IR index was significantly higher in cases than controls. Nonobese cases had a higher mean diastolic blood pressure and a more frequent family history of Androgenetic Alopecia than nonobese controls. A borderline difference in the HOMA-IR index was found in obese Androgenetic Alopecia cases vs. obese controls [P = 0.055, 95% confidence interval (CI) 2.36-4.20 vs. 1.75-2.73]. Free testosterone values were significantly higher in controls than cases, regardless of body mass index (BMI). A statistically significant additive effect for obesity plus alopecia was found, with significant trends for insulin, the HOMA-IR index, lipids and free testosterone when BMI and alopecia status were used to classify the participants. CONCLUSIONS: Our results support the recommendation for assessing insulin resistance and cardiovascular-related features and disorders in all young males with stage III or higher Androgenetic Alopecia, according to the Hamilton-Norwood classification
PMID: 19094069 [PubMed - indexed for MEDLINE]
Endocr Regul. 2005 Dec;39(4):127-31.
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
Starka L, Duskova M, Cermakova I, Vrbiková J, Hill M.
Institute of Endocrinology, Narodni 8, CZ 116 94 Prague 1, Czech Republic. lstarka@endo.cz
BACKGROUND: Polycystic ovary syndrome (PCOS), the most frequent endocrinopathy in women with estimated prevalence of 5-10 %, is characterised by a hormonal and metabolic imbalance of polygene autosomal trait. The complexity of symptoms and genetic base started up the hypothesis on the existence of male equivalent of PCOS. Precocious loss of hair before 30 years of age was suggested as one of the male symptoms of this syndrome. OBJECTIVES: The aim was to confirm the association of lower levels of follicle stimulating hormone (FSH) and sexual hormone binding globulin (SHBG) or higher free androgen index (FAI) in premature balding men with a reduced insulin sensitivity. PATIENTS/METHODS: The study included 30 men with premature hair loss (defined as grade 3 vertex or more on the alopecia classification scale by Hamilton with Norwood modification) starting before 30 years of age. The hormonal values of the investigated group were compared with those regarded as normal reference values obtained in a group of 256 males in the age of 20-40 years during the Czech population study of iodine deficiency. In all men with premature baldness besides hormonal level determinations insulin tolerance test was carried out. RESULTS: The observed group was divided into two subgroups. The first one showed similar hormonal changes as women with PCOS, namely subnormal SHBG, FSH or increased FAI. The other had either no anomalies in steroid spectrum or only lower SHBG. The groups did not differ either in BMI or in age. The group with hormonal profile resembling that of women with PCOS, showed significantly higher insulin resistance than the group without these changes. CONCLUSIONS: The findings are consistent with the hypothesis that at least a part of the men with premature androgenic alopecia could be considered as a male equivalent of the polycystic ovary syndrome of the women. These premature balding men represent a risk group for the development of impaired glucose tolerance or diabetes mellitus type 2.
Now for Aloe Vera,
Phytomedicine. 2009 Sep;16(9):856-63. Epub 2009 Mar 19.
Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus.
Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.
Department of Pharmacy, SahmYook University, Seoul, South Korea.
The effects of processed Aloe vera gel (PAG) on the course of established diet-induced non-insulin-dependent diabetes mellitus (NIDDM) were studied in C57BL/6J mice. NIDDM was induced in C57BL/6J mice by feeding them a high-fat diet. Mice exhibiting diet-induced obesity (DIO) with blood glucose levels above 180mg/dl were selected to examine the antidiabetic effects of PAG. Oral administration of PAG for 8 weeks reduced circulating blood glucose concentrations to a normal level in these DIO mice. In addition, the administration of PAG significantly decreased plasma insulin. The antidiabetic effects of PAG were also confirmed by intraperitoneal glucose tolerance testing. PAG appeared to lower blood glucose levels by decreasing insulin resistance. The administration of PAG also lowered triacylglyceride levels in liver and plasma. Histological examinations of periepididymal fat pad showed that PAG reduced the average size of adipocytes. These results demonstrate that the oral administration of PAG prevents the progression of NIDDM-related symptoms in high-fat diet-fed mice, and suggest that PAG could be useful for treating NIDDM.
Wound Repair Regen. 2008 Nov-Dec;16(6):784-90.
A poly-herbal formulation accelerates normal and impaired diabetic wound healing.
Gupta A, Upadhyay NK, Sawhney RC, Kumar R.
Department of Biochemical Pharmacology, Defence Institute of Physiology and Allied Sciences (DIPAS), Delhi, India. asheesh_gupta2001@yahoo.co.in
In the present study, a poly-herbal formulation (PHF) was prepared by combining the aqueous lyophilized leaf extracts of Hippophae rhamnoides L. and Aloe vera L. and the ethanol rhizome extract of Curcuma longa L., in an optimized ratio (1 : 7 : 1). The efficacy of PHF treatment was studied in normal and impaired diabetic rats using a full-thickness cutaneous wound model. Topical PHF treatment increased cellular proliferation and collagen synthesis at the wound site in normal rats, as evidenced by the significant increase in DNA, total protein, hydroxyproline, and hexosamine contents in comparison with a positive control treated with a povidone-iodine ointment. The histological examinations and matrix metalloproteinases expression also correlated well with the biochemical findings, confirming the efficacy of PHF in normal wounds. In the streptozotocin-induced diabetic rats, PHF treatment increased hydroxyproline and hexosamine content. A faster wound contraction was also observed in PHF-treated normal and diabetic rats. The PHF also promoted angiogenesis as evidenced by an in vitro chick chorioallantoic membrane model and in vivo up-regulated vascular endothelial growth factor expression. The results suggest that PHF possesses significant wound healing potential in both normal as well as chronic diabetic wounds.
Fitoterapia. 2008 Sep;79(6):456-7. Epub 2008 May 27.
Alpha-glucosidase inhibitor from Chinese aloes.
Jong-Anurakkun N, Bhandari MR, Hong G, Kawabata J.
Laboratory of Food Biochemistry, Division of Applied Bioscience,Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. j_nilubon@hotmail.com
Activity-guided fractionation of the methanol extract of Chinese aloes led to the isolation of aloeresin A, which demonstrated significant dose dependent alpha-glucosidase inhibitory activities, with IC(50) values of 11.94 and 2.16 mM, against rat intestinal sucrase and maltase, respectively.
Am J Chin Med. 2007;35(6):1037-46.
Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice.
Pérez YY, Jiménez-Ferrer E, Zamilpa A, Hernández-Valencia M, Alarcón-Aguilar FJ, Tortoriello J, Román-Ramos R.
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México. perezyy@yahoo.com
Insulin resistance, which precedes type 2 diabetes mellitus (T2DM), is a widespread pathology associated with the metabolic syndrome, myocardial ischemia, and hypertension. Finding an adequate treatment for this pathology is an important goal in medicine. The purpose of the present research was to investigate the effect of an extract from Aloe vera gel containing a high concentration of polyphenols on experimentally induced insulin resistance in mice. A polyphenol-rich Aloe vera extract (350 mg/kg) with known concentrations of aloin (181.7 mg/g) and aloe-emodin (3.6 mg/g) was administered orally for a period of 4 weeks to insulin resistant ICR mice. Pioglitazone (50 mg/kg) and bi-distilled water were used as positive and negative controls respectively. Body weight, food intake, and plasma concentrations of insulin and glucose were measured and insulin tolerance tests were performed. The insulin resistance value was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) formula. Results showed that the polyphenol-rich extract from Aloe vera was able to decrease significantly both body weight (p < 0.008) and blood glucose levels (p < 0.005) and to protect animals against unfavorable results on HOMA-IR, which was observed in the negative control group. The highest glucose levels during the insulin tolerance curve test were in the negative control group when compared to the Aloe vera extract and pioglitazone treated mice (p < 0.05). In conclusion, Aloe vera gel could be effective for the control of insulin resistance.
Cent Afr J Med. 2005 Nov-Dec;51(11-12):115-20.
Anti-diabetic activity of Aloe excelsa.
Gundidza M, Masuku S, Humphrey G, Magwa ML.
Department of Pharmacy, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe.
OBJECTIVE: To investigate the effect of Aloe excelsa powder on diabetes. DESIGN: The experiment was carried out in the laboratory on both normal and diabetic rats. Diabetes was induced in the rats by using streptozotocin. Thereafter, blood samples were taken from both the normal and diabetic rats and the sugar levels measured by using the Accutrend Alpha blood glucose monitoring kit. SETTING: The experiment was conducted in the laboratory in the Faculty of Medicine at the University of Zimbabwe. SUBJECTS: A total of 280 male albino rats weighing 250 g on average were used. They were obtained from the Animal House of the Medical School at the University of Zimbabwe. MAIN OUTCOME MEASURES: Reduction in sugar levels. RESULTS: The Aloe excelsa powder produced a dose-dependent reduction in the blood glucose in blood glucose levels. It also compared well with the effect of insulin. CONCLUSION: This study shows that Aloe excelsa has significant activity on glucose levels in rats and this, therefore, confirms the claims by traditional healers that this plant has anti-diabetic effects.
We see here how Aloe Vera can help Insulin resistance and Diabetes, and how Diabetes is connected to male pattern baldness.