DERMOVAN???

[jlee]

Hi, I would like to make my own topical spironolactone lotion but I can't find any dermovan...could you tell me if there is a product that can replace it?

 

[Dave001]

Hi, I would like to make my own topical spironolactone lotion but I can't find any dermovan...could you tell me if there is a product that can replace it?

You could try Vanicream. A 16 oz. jar is only $10.99. It's also an oil-in-water emulsion like Dermovan. Dermabase is another. There was a formulation published in a pharmaceutical journal for compounding 5% spironolactone in Dermabase (if that's what you're trying to do). You can buy Dermovan from nearly anywhere, if you really want it.

 

[Sir_LagaLot]

same here...i cant find this dermovan cream anyplace..

i'm gonna try dissolving 6 tabs of 100 mg spironolactone in glycerine + rosewater..

or maybe try getting it to dissolve in olive oil as a carrier.

 

[Dave001]

same here...i cant find this dermovan cream anyplace..

i'm gonna try dissolving 6 tabs of 100 mg spironolactone in glycerine + rosewater..

or maybe try getting it to dissolve in olive oil as a carrier.

I really don't understand this. Do some people really think that if you try hard enough, or enough times, that a chemical will magically dissolve in a solvent at a concentration it is insoluble at??

 

[Dave001]

same here...i cant find this dermovan cream anyplace..

i'm gonna try dissolving 6 tabs of 100 mg spironolactone in glycerine + rosewater..

or maybe try getting it to dissolve in olive oil as a carrier.

There's nothing special about Dermovan. It should be interchangeable with many oil-in-water emulsion cream bases ("vanishing" creams). Here's a link to Dermabase:

http://drugsdepot.com/cgi-bin/webc.cgi/ ... 8&p_catid=

A 1 lb. container is $13.90. Here is a formulation using Dermabase as a base:

Erickson MA III. Spironolactone 5% in Dermabase. Pharm Times 2001 Sep;67(9):79.

Dermovan is more expensive, but here's a place that has it if your mind is still set on it:

http://www.cyberpharmacy.com/store/prod ... sku=351551

 

[Sir_LagaLot]

hmm..who told you its not soluble in glycerine+rosewater...i searched alot for home made spironolactone threads...not just on this website but others...and there was one where somebody had tried it with

cucumber moisturizer (of all the darned things) AND rosewater+glycerine...it dissolved fine in both of these..

any vanishing cream does the trick?...or has it got be water-oil based..?

 

[Sir_LagaLot]

heres another post by iamnaked...
-----------
Without wanting to look like a boots salesman, several reasons why I think that their glycerin and rosewater is a good choice for a spironolactone vector:
1) Glycerin is a very good solvent; many things dissolve better in a glycerin/alcohol mix than in alcohols alone.
2) It is a moisturiser, which helps to counteract the drying effects of e.g. nizoral.
3) It contains boric acid, and a low pH is meant to be good for spironolactone stability.
4) It smells less than other stuff I experimented with.
5) It is cheap ~£2