IvanXproject
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I recently came across something on hairlosscure 2020 that I found very interesting. Credit to "Maddy" for writing this/ spreading this information:
"JAK inhibitors are a very interesting angle. There are mast cells, A LOT OF THEM, in the skin. They secrete all kinds of inflammatory mediators, including histamine and CRH, both of which in some studies are linked to hair loss. The CRH seems to be functioning in an autocrine or paracrine way, although if there is overload, like in histamine intolerance, it could be enough to be systemic/endocrine – pumping up adrenal function and DHEA (which can convert to DHT). Interestingly, testosterone and DHT ameliorate histamine – they degrade it. So maybe the skin converts it to rid itself of the histamine reactions. Estrogen does not degrade histamine, in fact the opposite is true. Progesterone binds to the AR receptor and also acts to stabilize mast cells. mast cells do not have to fully degranulate to release their inflammatory cytokines, they can do it selectively, they “leak”. May be worth trying to find out if you have a naturally higher level of histamine. If you have low DAO enzyme, this enzyme degrades L-histadine in foods, your body will convert the excess histadine coming in from the gut to histamine – this is #1 cause of histamine intolerance – check out symptoms to see if you match (google it). DAO gene is AOC1 on 23andme, and you need not have every symptom to have a problem. If you have slowed HNMT or MAO enzymes you can also have higher histamine levels. DAO is also produced during pregnancy, by the placenta, in HUGE AMOUNTS, 500-1000x the non-pregnant state. Women with allergies often have complete remission. This is why women are so tired during first trimester, histamine gets lowered by the DAO increase, which ramps up during first month then stays high. The body does get used to the new lower level. It is like if you titer up on a anti-histamine like Elavil/amitryptiline, you are a zombie until body adjusts. But antihistamines block the H receptor they do not get rid of the histamine. DAO actually prevents the raw material from entering the system. You can buy the enzyme and take it if you have histamine intolerance. You can get low DAO function even if not genetic, by medicines or gut disfunction. And you do know women nearly completely stop shedding hair during pregnancy too (and then catch up with a big shed post partum). So is it the DAO or the Progesterone? Or both????
DAO enzymes can be found on Amazon. For it to be effective, you need to take 2 capsules before every meal, 3 if big meal with a lot of protein, and 1 cap before snacks. If you are not religious about it, don’t bother, the body is very efficient at making histamine if you let histadine in.
JAK inhibitors are being trialed for arthritis, look up low DAO and arthritis and asthma and MS and a number of other inflammatory issues….you’ll find hits."
What du you guys think? Could DAO enzymes do anything for hair loss?
"JAK inhibitors are a very interesting angle. There are mast cells, A LOT OF THEM, in the skin. They secrete all kinds of inflammatory mediators, including histamine and CRH, both of which in some studies are linked to hair loss. The CRH seems to be functioning in an autocrine or paracrine way, although if there is overload, like in histamine intolerance, it could be enough to be systemic/endocrine – pumping up adrenal function and DHEA (which can convert to DHT). Interestingly, testosterone and DHT ameliorate histamine – they degrade it. So maybe the skin converts it to rid itself of the histamine reactions. Estrogen does not degrade histamine, in fact the opposite is true. Progesterone binds to the AR receptor and also acts to stabilize mast cells. mast cells do not have to fully degranulate to release their inflammatory cytokines, they can do it selectively, they “leak”. May be worth trying to find out if you have a naturally higher level of histamine. If you have low DAO enzyme, this enzyme degrades L-histadine in foods, your body will convert the excess histadine coming in from the gut to histamine – this is #1 cause of histamine intolerance – check out symptoms to see if you match (google it). DAO gene is AOC1 on 23andme, and you need not have every symptom to have a problem. If you have slowed HNMT or MAO enzymes you can also have higher histamine levels. DAO is also produced during pregnancy, by the placenta, in HUGE AMOUNTS, 500-1000x the non-pregnant state. Women with allergies often have complete remission. This is why women are so tired during first trimester, histamine gets lowered by the DAO increase, which ramps up during first month then stays high. The body does get used to the new lower level. It is like if you titer up on a anti-histamine like Elavil/amitryptiline, you are a zombie until body adjusts. But antihistamines block the H receptor they do not get rid of the histamine. DAO actually prevents the raw material from entering the system. You can buy the enzyme and take it if you have histamine intolerance. You can get low DAO function even if not genetic, by medicines or gut disfunction. And you do know women nearly completely stop shedding hair during pregnancy too (and then catch up with a big shed post partum). So is it the DAO or the Progesterone? Or both????
DAO enzymes can be found on Amazon. For it to be effective, you need to take 2 capsules before every meal, 3 if big meal with a lot of protein, and 1 cap before snacks. If you are not religious about it, don’t bother, the body is very efficient at making histamine if you let histadine in.
JAK inhibitors are being trialed for arthritis, look up low DAO and arthritis and asthma and MS and a number of other inflammatory issues….you’ll find hits."
What du you guys think? Could DAO enzymes do anything for hair loss?
