Creating a custom topical jak inhibitor?

[Rockinlove]

This story held my interest today. Wondering if anyone here can help in creating a similar minoxidil jak inhibitor combo?

It's merely one poster. Neverthless surmise and conjecture requires experimentation to arrive at a tenable hypothesis.

http://www.hairlosscure2020.com/so-jak-inhibitors-could-yet-still-cure-androgenic-alopecia/#comments

 

[RhinestoneHLT]

This story held my interest today. Wondering if anyone here can help in creating a similar minoxidil jak inhibitor combo?

It's merely one poster. Neverthless surmise and conjecture requires experimentation to arrive at a tenable hypothesis.

http://www.hairlosscure2020.com/so-jak-inhibitors-could-yet-still-cure-androgenic-alopecia/#comments

Do you realize it would cost hundreds a month?

 

[Rockinlove]

Do you realize it would cost hundreds a month?

I was hoping that the generics would be cheaper. Apparently they are not.

 

[RhinestoneHLT]

I was hoping that the generics would be cheaper. Apparently they are not.

Mass market is the only way for this to become affordable sadly.

Even then I still would bet the branded topical would run around 100$ a month.

 

[Rockinlove]

It would take nearly a decade for this to be even available commercially. And like you state there is a strong possibility that this is going to be fairly expensive: sigh:

Mass market is the only way for this to become affordable sadly.

Even then I still would bet the branded topical would run around 100$ a month.

 

[Aleksandar]

100 dollar a month expensive for getting your hair back..?

 

[Rockinlove]

That would still be very affordable. Apparently, a 30 day supply of the drug costs $2,055.13.

100 dollar a month expensive for getting your hair back..?

 

[mr_robot]

Just use topical Sulfasalazine, it pretty much does the same thing as Tofacitinib, namely blocks IL-6 (although not as powerfully) :

Sulfasalazine:
http://www.mdpi.com/2072-6651/7/2/553/htm

Tofacitinib
http://www.ncbi.nlm.nih.gov/pubmed/24665995

Hell even Vitamin E Succinate:
http://www.ncbi.nlm.nih.gov/pubmed/17262802

What is IL-6 and why it is bad?
http://www.ncbi.nlm.nih.gov/pubmed/21881585

As a side note, IL-6 inhibition is probably the reason swisstemples was able to regrow hair, as it is downstream PGD2.

 

[Dench57]

Just use topical Sulfasalazine, it pretty much does the same thing as Tofacitinib, namely blocks IL-6 (although not as powerfully) :

Sulfasalazine:
http://www.mdpi.com/2072-6651/7/2/553/htm

Tofacitinib
http://www.ncbi.nlm.nih.gov/pubmed/24665995

Hell even Vitamin E Succinate:
http://www.ncbi.nlm.nih.gov/pubmed/17262802

What is IL-6 and why it is bad?
http://www.ncbi.nlm.nih.gov/pubmed/21881585

As a side note, IL-6 inhibition is probably the reason swisstemples was able to regrow hair, as it is downstream PGD2.

Ummm, no.
Firstly, Sulfalasazine wouldn't work topically because it's a prodrug - its biologically inactive until metabolized by the body.
Secondly, Tofa is a JAK stat inhibitor and has a completely different mechanism of action to Sulfasalazine.
And regrowing hair with IL-6 inhibition? Seriously?

 

[Swoop]

Jup, I'll use my simple but logical argument again why targeting IL-6 won't work. Agents that target IL-6; https://en.wikipedia.org/wiki/Anti-IL-6.

Again, if targeting IL-6 would show any hair related changes we would know already. Why? Well there are almost always people involved in clinical trials with hair loss to some degree. Androgenetic Alopecia is prevalent to some degree in many men. Hair regrowth doesn't get unnoticed either. Not a single mention of hair growth changes we know of compounds that target IL-6, not even a single case report.

 

[mr_robot]

Ummm, no.
Firstly, Sulfalasazine wouldn't work topically because it's a prodrug - its biologically inactive until metabolized by the body.
Secondly, Tofa is a JAK stat inhibitor and has a completely different mechanism of action to Sulfasalazine.
And regrowing hair with IL-6 inhibition? Seriously?

The mechanism of action may the different but IL-6 inhibition is the end result of both. IL-6 is downstream of DHT in the follicle, so yes via IL-6 inhibition in the follicle is possible although I would never recommend the use of either Sulfalasazine or Tofacitinib for hair loss - it was said tongue-in-cheek but if anyone is using them and claiming it works it is probably via IL-6.

- - - Updated - - -

Jup, I'll use my simple but logical argument again why targeting IL-6 won't work. Agents that target IL-6; https://en.wikipedia.org/wiki/Anti-IL-6.

Again, if targeting IL-6 would show any hair related changes we would know already. Why? Well there are almost always people involved in clinical trials with hair loss to some degree. Androgenetic Alopecia is prevalent to some degree in many men. Hair regrowth doesn't get unnoticed either. Not a single mention of hair growth changes we know of compounds that target IL-6, not even a single case report.

I'm not saying blocking IL-6 regrows hair, the guy from the link in the OP claiming Tofacitinib works says he is using it using in conjunction with minoxidil. DHT->IL-6 happens in the follicle so serum IL-6 inhibition is not going to do anything.

 

[Dench57]

The mechanism of action may the different but IL-6 inhibition is the end result of both. IL-6 is downstream of DHT in the follicle, so yes via IL-6 inhibition in the follicle is possible although I would never recommend the use of either Sulfalasazine or Tofacitinib for hair loss - it was said tongue-in-cheek but if anyone is using them and claiming it works it is probably via IL-6.

I'm still not sure why you think IL-6 is so important. JAK Stat is a complex signalling pathway which goes far beyond IL-6 and is posited as being useful for our purposes as it is involved in cell senescence and stem cell functions.

 

[Rockinlove]

I have a somewhat tenuous grasp of the science of chemistry. Like you said, I am not certain that Sulfasalazine and Tofacitinib would have a similar impact on hair loss.

However, if anyone here with the commensurate resources to experiment then please do so. I, for one, am tired of Big Pharma baiting us with the promise of a cure every few years; hope is the quintessential human delusion. To hope for something to happen is the equivalent of giving up.

We need a more proactive approach towards hair loss rather than waiting for a cure to be commercially available.

For now, my descent into madness has led to me seeking out centrifuges for PRP online.

I'm still not sure why you think IL-6 is so important. JAK Stat is a complex signalling pathway which goes far beyond IL-6 and is posited as being useful for our purposes as it is involved in cell senescence and stem cell functions.

 

[Rockinlove]

There is no smoke without fire and the success of the individual who used a topical JAK/.minoxidil combo might not be a mere flash in the pan.

A small update. Apparently, JAK inhibitors do also espouse a certain potential for Androgenetic alopecia and that may well be the reason for the acquisition.

" Dr. Angela Christiano and her team published some findings (FULL TEXT AVAILABLE) that suggest a better than negligible chance of JAK inhibitors also working to treat androgenic alopecia. This time, they managed to grow hair on rats via a topical formulation of both Ruxolitinib and Tofacitinib."


http://www.hairlosscure2020.com/hug...ould-also-regrow-hair-in-androgenic-alopecia/

 

[IvanXproject]

You are right OP, we should create a custom topical JAK inhibitor. That would be our only chance to get a new treatment this year (except from getting the SM formula, but that seems impossible lol)

 

[Hulahoop]

I'd be interested in trying this as a topical, have seen tofacitinib citrate 5g for $450, on a U.S chemical research site achemblock, but seems they will only sell it for research purposes, and not just to anybody, how do others get around this when setting up group buys?