Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

[Balding curse]

It's still rats study but I think it's interesting.

Androgenetic alopecia (Androgenetic Alopecia) is highly prevalent in current society but lacks effective treatments. The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization in the perifollicular microenvironment is the leading cause of Androgenetic Alopecia. Herein, we designed a ceria nanozyme (CeNZ)-integrated microneedles patch (Ce-MNs) that can alleviate oxidative stress and promote angiogenesis simultaneously to reshape the perifollicular microenvironment for Androgenetic Alopecia treatment. On the basis of the excellent mechanical strength of Ce-MNs, the encapsulated CeNZs with catalase- and superoxide-mimic activities can be efficiently delivered into skin to scavenge excessive ROS. Moreover, the mechanical stimulation induced by the administration of MNs can remodel the microvasculature in the balding region. Compared with minoxidil, a widely used clinical drug for Androgenetic Alopecia treatment, Ce-MNs exhibited accelerated hair regeneration in the Androgenetic Alopecia mouse model at a lower administration frequency without inducing significant skin damage. Consequently, such a safe and perifollicular microenvironment-shaping MNs patch shows great potential for clinical Androgenetic Alopecia treatment.

https://pubs.acs.org/doi/10.1021/acsnano.1c05272

 

[Jakejr]

It’s an Asian study with mice. Premise is hair follicles retrograde because of ROS(which damages cells/DNA)/vascularuzation. Ok. let’s agree there definitely a lack of something & perhaps an abundance of something else.
The researchers have designed a “patch” to, I assume delivers minoxidil etc BETTER to struggling follicles & lessen damage to hair cells resulting in hair regrowth?
The link provided doesn’t show whole study unless purchased. I was particularly interested in METHODS section where details of patch & delivery system is made clear… It’s interesting, but I need to see this patch & research it more..

 

[Jakejr]

As a first step, the researchers coated cerium nanoparticles with a biodegradable polyethylene glycol-lipid compound. Then they made the dissolvable microneedle patch by pouring a mixture of hyaluronic acid -- a substance that is naturally abundant in human skin -- and cerium-containing nanoparticles into a mold. The team tested control patches and the cerium-containing ones on male mice with bald spots formed by a hair removal cream. Both applications stimulated the formation of new blood vessels around the mice's hair follicles. However, those treated with the nanoparticle patch showed faster signs of hair undergoing a transition in the root, such as earlier skin pigmentation and higher levels of a compound found only at the onset of new hair development. These mice also had fewer oxidative stress compounds in their skin. Finally, the researchers found that the cerium-containing microneedle patches resulted in faster mouse hair regrowth with similar coverage, density and diameter compared with a leading topical treatment and could be applied less frequently. Microneedle patches that introduce cerium nanoparticles into the skin are a promising strategy to reverse balding for androgenetic alopecia patients, the researchers say.
So we are talking about nano-particles injected into scalp with microneedle patch.

"Microneedle patches that introduce cerium nanoparticles into the skin are a promising strategy to reverse balding for androgenetic alopecia patients," concluded the researchers.
Next question is what are cerium nanoparticles?

 

[Get my hair back]

I read that nanoparticles can effectively penetrate deep into the epidermis, then it is not clear why to use a patch?

 

[JaneyElizabeth]

The issue seems to be that male pattern baldness is hormonally driven and not so much by lack of nutrients although it's a bit chicken and egg. So contrary to what everyone thinks, male pattern baldness seems to be driven by the body and through hormonal changes. If it has to do with say intestinal flora, then why are the white/Semitic races the only/virtually race(s) the ones who suffer from it? Why don't females have the wrong gut flora, except rarely or whatever.

male pattern baldness has it's onset during puberty as does the commencement of beard growth. So these, for whites, appear to be secondary sexual characteristics and not any form of "disease". Things might accelerate it but it's clear that it is androgen driven. Most view male pattern baldness as like grass growing in the parking lot and it's not. Topical treatments probably shed more darkness than light because they seem like "fertilizers" that you place on top of the balding areas but that's much more complicated. But people can't agree whether topical estrogen differs from parenteral estrogen in terms of effects but it seems to be only parenteral effects that cause re-growth but there could also be DHT effects at the surface which estrogen ameliorates.

Anyway, I am reasonably certain that at least in some contexts, stopping beard growth will prevent male pattern baldness from presenting. Whether doing this after male pattern baldness has occurred works is unclear. Often beard growth stops or largely stops as hair is regrown but this seems to be age driven and driven by say follicle diameter. But given the extremely high correlations between most aspects of beard and scalp hair growth, it might be some sort of loose type of maintaining head hair in stasis between beard growth which can be incredibly substantial similar to many female's scalp hair, and male scalp hair moving in opposite directions but we don't know how any of this might be effectuated. Anecdotally, some FtM's seem to lose hair while growing minoxidil beards but they also tend to take simply enormous amounts of T, many of them, to the point where they have body hair everywhere, front and back. That's a kind of male look for many XY's but very few want or like that.

But it's the actual wounding from microneedling that appears to heal follicles via stem cell production. Microneedling seems to rejuvenate all skin tissue and it's incredibly effective on scar tissue that presents outward, but not ice pick types of scars. Without the wounding in this proposal, there has to be some way to induce stem cells plus there is collagen induction. Does this increase collagen production in the scalp? If not, then this is of limited interest because oral min will likely work far better for most people and adding microneedling clearly "works" for many people. Anagen is the key and increasing anagen is necessary to reverse baldness at least outwardly. So dormant follicles aren't dead but only have say anagen type that is extremely compressed to the point that they are barely visible and not terminal hairs. Conjecture in my opinion will never resolve or cure male pattern baldness because the white male body WANTS a hormonal condition that promotes male pattern baldness. You guys are all sailing against the wind. This is not a disease. You were made this way. It doesn't mean that there are no "cures" but it won't come via conjecture in my opinion. DHT is so persistent that even castrates/post SRS transfemales at times struggle to resolve the backdoor pathway albeit quite uncommon, it's common enough that it is seemingly verified as occuring somehow.

Janey

 

[-specter-]

The issue seems to be that male pattern baldness is hormonally driven and not so much by lack of nutrients although it's a bit chicken and egg. So contrary to what everyone thinks, male pattern baldness seems to be driven by the body and through hormonal changes. If it has to do with say intestinal flora, then why are the white/Semitic races the only/virtually race(s) the ones who suffer from it? Why don't females have the wrong gut flora, except rarely or whatever.

male pattern baldness has it's onset during puberty as does the commencement of beard growth. So these, for whites, appear to be secondary sexual characteristics and not any form of "disease". Things might accelerate it but it's clear that it is androgen driven. Most view male pattern baldness as like grass growing in the parking lot and it's not. Topical treatments probably shed more darkness than light because they seem like "fertilizers" that you place on top of the balding areas but that's much more complicated. But people can't agree whether topical estrogen differs from parenteral estrogen in terms of effects but it seems to be only parenteral effects that cause re-growth but there could also be DHT effects at the surface which estrogen ameliorates.

Anyway, I am reasonably certain that at least in some contexts, stopping beard growth will prevent male pattern baldness from presenting. Whether doing this after male pattern baldness has occurred works is unclear. Often beard growth stops or largely stops as hair is regrown but this seems to be age driven and driven by say follicle diameter. But given the extremely high correlations between most aspects of beard and scalp hair growth, it might be some sort of loose type of maintaining head hair in stasis between beard growth which can be incredibly substantial similar to many female's scalp hair, and male scalp hair moving in opposite directions but we don't know how any of this might be effectuated. Anecdotally, some FtM's seem to lose hair while growing minoxidil beards but they also tend to take simply enormous amounts of T, many of them, to the point where they have body hair everywhere, front and back. That's a kind of male look for many XY's but very few want or like that.

But it's the actual wounding from microneedling that appears to heal follicles via stem cell production. Microneedling seems to rejuvenate all skin tissue and it's incredibly effective on scar tissue that presents outward, but not ice pick types of scars. Without the wounding in this proposal, there has to be some way to induce stem cells plus there is collagen induction. Does this increase collagen production in the scalp? If not, then this is of limited interest because oral min will likely work far better for most people and adding microneedling clearly "works" for many people. Anagen is the key and increasing anagen is necessary to reverse baldness at least outwardly. So dormant follicles aren't dead but only have say anagen type that is extremely compressed to the point that they are barely visible and not terminal hairs. Conjecture in my opinion will never resolve or cure male pattern baldness because the white male body WANTS a hormonal condition that promotes male pattern baldness. You guys are all sailing against the wind. This is not a disease. You were made this way. It doesn't mean that there are no "cures" but it won't come via conjecture in my opinion. DHT is so persistent that even castrates/post SRS transfemales at times struggle to resolve the backdoor pathway albeit quite uncommon, it's common enough that it is seemingly verified as occuring somehow.

Janey

I have Asian descent on my father's side and probably Irish on my mother's side as many of my relatives have red hair. I have a fairly feminine face according to many (I look like Keanu Reeves when he was 20), I have little body hair and very little beard. By the time the Androgenetic Alopecia started I saw all my hair becoming duller and curlier. I went from being "cute" to "average ugly", I no longer recognize myself in the mirror and I feel very bad about it, and to think that when I was younger, girls envied my hair, now I envy them

 

[Capone]

I have Asian descent on my father's side and probably Irish on my mother's side as many of my relatives have red hair. I have a fairly feminine face according to many (I look like Keanu Reeves when he was 20), I have little body hair and very little beard. By the time the Androgenetic Alopecia started I saw all my hair becoming duller and curlier. I went from being "cute" to "average ugly", I no longer recognize myself in the mirror and I feel very bad about it, and to think that when I was younger, girls envied my hair, now I envy them

Here we go another full head drama queen

 

[Get my hair back]

What happened to the guys, whining noodlers.. I'm ashamed of you. You'd probably lock yourself up at home and hang yourself by the balls if you went bald like me.

 

[Jakejr]

This thread is about Cerium oxide delivered to scalp with microneedle patch.
I have since ordered some fine grade cerium & some microneedle patches to do my experiments.
it is interesting that cerium is a rare earth mineral with quite a long history in the medical field research fighting many serious diseases because it’s molecular structure somehow puts less stress on important cellular processes. And just maybe follicular health & hair growth is one of them.

 

[Get my hair back]

This thread is about Cerium oxide delivered to scalp with microneedle patch.
I have since ordered some fine grade cerium & some microneedle patches to do my experiments.
it is interesting that cerium is a rare earth mineral with quite a long history in the medical field research fighting many serious diseases because it’s molecular structure somehow puts less stress on important cellular processes. And just maybe follicular health & hair growth is one of them.

My cerium is also on the way, I will receive it one of these days. I'll add it to my mode. It won't get any worse. How long have you been using it?

 

[Jakejr]

Just ordered it.,, so maybe this week hopefully.

 

[Balding curse]

This thread is about Cerium oxide delivered to scalp with microneedle patch.
I have since ordered some fine grade cerium & some microneedle patches to do my experiments.
it is interesting that cerium is a rare earth mineral with quite a long history in the medical field research fighting many serious diseases because it’s molecular structure somehow puts less stress on important cellular processes. And just maybe follicular health & hair growth is one of them.

Is Cerium oxide the same polishing compound powder?
And how you are going to dissolve it?

 

[kiwi666]

Anyways what the f*** is a microneedling patch?!?

 

[Jakejr]

It appears the patch was made with pure cerium oxide sprinkled on the dissolvable microneedles with diluted .05 hyaluronic acid. It appears the patch was inserted for hours? than removed & results calculated at day14 & day 28. There were two controls to measure against. One minoxidil & other cerium oxide administered intradermally?
Anyways the dissolvable patch won..This was done on mice..

 

[StayPositive]

It appears the patch was made with pure cerium oxide sprinkled on the dissolvable microneedles with diluted .05 hyaluronic acid. It appears the patch was inserted for hours? than removed & results calculated at day14 & day 28. There were two controls to measure against. One minoxidil & other cerium oxide administered intradermally?
Anyways the dissolvable patch won..This was done on mice..

It seems difficult to reproduce

This thing works because it reduces reactive oxygen species (ROS). ROS are essential to the hair degeneration process. DHT and other androgens increase ROS level at the hair follicles, this is the start of the cascade.

Reducing ROS effectively will stop further loss and miniaturization. i dont know if it will regrow some hair at the hairline but i think it can increase overall density since a lot of guys experience this with fina/duta/antiandrogens

Currently i am on topical glutathione, vitamine c, resveratrol and melatonin. All ROS scavengers