I have been using finastride 1 mg for over 10 years now but not noun stop i take it for 2 years usually and then get a year break but what has made me surprised is this that everytime i am on finastride i dont get any hayfever or allergic reaction to the foods which i have usually(its not life threatening though)has anyone else experienced such an effect from finastride?
Can Finastride Have Some Antihistamine Effects?
- Thread starter Ashkan63
- Start date
Basically i can say the first weeks after stopping i get bad shedding but then it stabilises and i can say kind of acceptable for about 6 months but after that my hair start to look very weak and unhealthy till one year point that i have lost almost everything i had got but the good point is that when i start finasteride my hair gets back to normal in six months ,i am a diffuse thinner and i lose mostly on my hairline
10 year but not noun stop ,the longest period i have been on it noun stop is about 2 and half years,side effects build up for me mostly when i reach to 1+ but the usually go away a few months after i stop ,insomnia and deppression are the worst but i get lower libido and softer erection,but all of this worth for me as finasteride does several things for me not only saving my hair,i had to take zantac for my stomach asid every day which has its own sids,also antihistamine during spring but when i am on finasteride i dont need them
- Reaction score
- 373
Ashkan, I've been following your post for a while, because you seem to have been "cycling" finasteride for a long time. I saw people discussing this long ago but you're the only one actually doing it with success.
As you mentioned, as time goes, finasteride loses its effect and the sides build up, usually at the two year mark you have to drop it and reboot it several months or a year later. In the meantime, whenever you go back on finasteride, you were able to regain what you lost during the off period.
I've been pondering this topic for long. finasteride losing effect seems common. For most people it happens at around the five year mark. I experienced the same. For some people the sides don't build up, for some they do, and when they do, it's usually mental related.
I believe androgen receptor upregulation plays a big role in it. There has been speculations on this for years.
AR regulation not only explains why finasteride loses its effect, but also gives a possible explanation to the myth of post finasteride syndrome (well considering the solid evidence of PFS it might be unfair to call it a myth). When you're on finasteride your body upregulates ARs to regain its homeostasis. After you quit, your body has 300% DHT which is overwhelmingly high and causes a intense down regulation of ARs, which goes to different extent in different tissues. For some reason the ARs in specific parts of the body never bounce back to normal even when the general androgen signalling returns, thus PFS.(Summarized from a solvePFS thread discussing restoration of androgen sensitivity)
I think finasteride does give you tolerance. There's no way a potent 5AR used long term won't do that. Actually if we consider the steroid cycling approach of body builders, it makes much sense to go off finasteride every once in a while to maximize its effect and minimize sides, especially when you notice side effects creeping up, which indicates you're body has been deprived of androgen signalling substantially.
The problem is we don't know the exact safe approach to do this (unlike steroid users who have more or less empirically agreed cycling plans). We don't dare risking losing hair on that off cycle either. You mentioned you were losing hair in a diffuse pattern, which can be more easily regrown. However for those losing their hairline in a intense way this may not work out...
finasteride is the devil's potion!...
(BTW as I remember you were looking into seti too. Are you on it now?)
As you mentioned, as time goes, finasteride loses its effect and the sides build up, usually at the two year mark you have to drop it and reboot it several months or a year later. In the meantime, whenever you go back on finasteride, you were able to regain what you lost during the off period.
I've been pondering this topic for long. finasteride losing effect seems common. For most people it happens at around the five year mark. I experienced the same. For some people the sides don't build up, for some they do, and when they do, it's usually mental related.
I believe androgen receptor upregulation plays a big role in it. There has been speculations on this for years.
AR regulation not only explains why finasteride loses its effect, but also gives a possible explanation to the myth of post finasteride syndrome (well considering the solid evidence of PFS it might be unfair to call it a myth). When you're on finasteride your body upregulates ARs to regain its homeostasis. After you quit, your body has 300% DHT which is overwhelmingly high and causes a intense down regulation of ARs, which goes to different extent in different tissues. For some reason the ARs in specific parts of the body never bounce back to normal even when the general androgen signalling returns, thus PFS.(Summarized from a solvePFS thread discussing restoration of androgen sensitivity)
I think finasteride does give you tolerance. There's no way a potent 5AR used long term won't do that. Actually if we consider the steroid cycling approach of body builders, it makes much sense to go off finasteride every once in a while to maximize its effect and minimize sides, especially when you notice side effects creeping up, which indicates you're body has been deprived of androgen signalling substantially.
The problem is we don't know the exact safe approach to do this (unlike steroid users who have more or less empirically agreed cycling plans). We don't dare risking losing hair on that off cycle either. You mentioned you were losing hair in a diffuse pattern, which can be more easily regrown. However for those losing their hairline in a intense way this may not work out...
finasteride is the devil's potion!...
(BTW as I remember you were looking into seti too. Are you on it now?)
- Reaction score
- 373
As for the antihistamine effect,
It's interesting. Could it have anything to do with PGD2? PGD2 is the downstream substance of androgen signaling. It's related to inflammation and immune reaction.
Cetirizine is anti histamine. It is also said to greatly reduce the male pattern baldness itch/inflammation and shedding in some people.
The link between male pattern baldness and autoimmune disorder is obviously there.
It's interesting. Could it have anything to do with PGD2? PGD2 is the downstream substance of androgen signaling. It's related to inflammation and immune reaction.
Cetirizine is anti histamine. It is also said to greatly reduce the male pattern baldness itch/inflammation and shedding in some people.
The link between male pattern baldness and autoimmune disorder is obviously there.
Hey wmq
To explain my cycle i can say i have to say i have 70% of my hair which i had when i was 20 which i think it would be 40% maybe without finasteride but def i have lost some.i dont agree with androgen upregulation although i belive the body make some kind of tolerance in front of finasteride but i think its more like tolerance the body make in fromt of steroids in treating immune system disorders.i strongly believe hair loss is a immune sustem disorder and caused by inflammation,as i said before finasteride has many other effects on my body which are immune sustem related,so how its possible if dht has nothing to do with immune system,yea i was really interested in seti when i first read about it i told thats it but i could not find a good source and also people using it did not report good feedback.generally i can say finasteride is the most effective drug out there(i dont know about dutasteride and dont really want to try it either)but it has its own problems and does not cure hairloss ,just delay it
To explain my cycle i can say i have to say i have 70% of my hair which i had when i was 20 which i think it would be 40% maybe without finasteride but def i have lost some.i dont agree with androgen upregulation although i belive the body make some kind of tolerance in front of finasteride but i think its more like tolerance the body make in fromt of steroids in treating immune system disorders.i strongly believe hair loss is a immune sustem disorder and caused by inflammation,as i said before finasteride has many other effects on my body which are immune sustem related,so how its possible if dht has nothing to do with immune system,yea i was really interested in seti when i first read about it i told thats it but i could not find a good source and also people using it did not report good feedback.generally i can say finasteride is the most effective drug out there(i dont know about dutasteride and dont really want to try it either)but it has its own problems and does not cure hairloss ,just delay it