Black tea compound, blocks alpha 5 reductase, and A-receptor

[michael barry]

http://carcin.oxfordjournals.org/cgi/co ... /25/7/1109




--------------------------------------------------------------------------------

ARTICLE


Theaflavin-3,3'-digallate and penta-O-galloyl-ß-D-glucose inhibit rat liver microsomal 5-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells
Hung-Hsiao Lee1, Chi-Tang Ho2 and Jen-Kun Lin1,3
1 Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan and 2 Department of Food Science, Rutgers University, Brunswick, New Jersey, USA





Very impressive...........................I wonder if one could just brew some very strong black tea and add a little alcohol as a carrier and use it topically?

Doctor, Bryan, Wook, anyone with any ideas?


BTW---Black tea is one of the compounds mentioned in the male pattern baldness-research article that supposedly inhibits TGF-beta. Can anything truly be so good for hair and right under out noses? Very interesting.........

 

[Cassin]

I drink about 2 to 10 cups of tea a day! Very cool.

 

[Artista]

I drink a lot of tea too--- to bad it does squat.

 

[mulder]

I drink a lot of tea too--- to bad it does squat.

How do you know it does squat?

 

[wookster]

Tea also has a diuretic effect...

ensativo: aranoid: :scratch:

 

[docj077]

Tea also has a diuretic effect...

ensativo: aranoid: :scratch:

Not as much as you'd think.

 

[docj077]

Everyone should carefully monitor how much green and black tea they drink. They both have high concentrations of fluoride in them. Fluoride is incredibly toxic to the thyroid gland. If you or any immediate family members have ever had thyroid problems, I'd probably steer clear of both large amounts of tea and large amounts of soy products.

It's pretty tough to fight male pattern baldness when you have an underlying thyroid disorder, as well.

Remember, everything in moderation.

 

[IBM]

for extreme attacks extreme defenses.

 

[michael barry]

Doctor,


I was thinking about the tea compounds in a topical sense. Do you think they'd have any use topically in the form of black tea extract in a topical application?

 

[docj077]

Doctor,


I was thinking about the tea compounds in a topical sense. Do you think they'd have any use topically in the form of black tea extract in a topical application?

Depends upon whether or not the compound in the tea that you're referring to can work topically in terms of penetrance or solubility in a particular solution. Black tea will stain the scalp, so we need the actual compound isolated.

 

[frailstar]

Re: Black tea compound, blocks alpha 5 reductase, and A-rece

http://carcin.oxfordjournals.org/cgi/content/full/25/7/1109




--------------------------------------------------------------------------------

ARTICLE


Theaflavin-3,3'-digallate and penta-O-galloyl-ß-D-glucose inhibit rat liver microsomal 5-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells
Hung-Hsiao Lee1, Chi-Tang Ho2 and Jen-Kun Lin1,3
1 Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan and 2 Department of Food Science, Rutgers University, Brunswick, New Jersey, USA





Very impressive...........................I wonder if one could just brew some very strong black tea and add a little alcohol as a carrier and use it topically?

Doctor, Bryan, Wook, anyone with any ideas?


BTW---Black tea is one of the compounds mentioned in the male pattern baldness-research article that supposedly inhibits TGF-beta. Can anything truly be so good for hair and right under out noses? Very interesting.........

OMG you're not suggesting that something that goes into your mouth (ie. diet) could affect male pattern baldness? What a wild concept! Genetics are too strong, can't be over ridden! Nope.

 

[docj077]

Re: Black tea compound, blocks alpha 5 reductase, and A-rece

http://carcin.oxfordjournals.org/cgi/content/full/25/7/1109




--------------------------------------------------------------------------------

ARTICLE


Theaflavin-3,3'-digallate and penta-O-galloyl-ß-D-glucose inhibit rat liver microsomal 5-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells
Hung-Hsiao Lee1, Chi-Tang Ho2 and Jen-Kun Lin1,3
1 Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan and 2 Department of Food Science, Rutgers University, Brunswick, New Jersey, USA





Very impressive...........................I wonder if one could just brew some very strong black tea and add a little alcohol as a carrier and use it topically?

Doctor, Bryan, Wook, anyone with any ideas?


BTW---Black tea is one of the compounds mentioned in the male pattern baldness-research article that supposedly inhibits TGF-beta. Can anything truly be so good for hair and right under out noses? Very interesting.........

OMG you're not suggesting that something that goes into your mouth (ie. diet) could affect male pattern baldness? What a wild concept! Genetics are too strong, can't be over ridden! Nope.

He says to use it topically. Where do you see M. Barry mention tea being used internally?

Also, you're right. Genetics are far too strong to be overcome by diet. Our most beneficial herbs and supplements (turmeric, green/black tea, soy products...except saw palmetto) for male pattern baldness are actually toxic to various organs of the body at the doses or treatment time periods that are required for male pattern baldness treatment.

 

[michael barry]

Thank you for your reply Doctor, and interesting info about the flourine levels in teas as I certainly didn't know that. Its good to keep in mind.



Frailstar............................some of the chemicals released by the dermal papilla like TGF-beta and DPPK and PKC and thrombospondin and FGF-5 that we might want to supress in scalp hairs may or may not be important in other body and organ and carcinomic-suppressive functions in the body. For instance TGF-beta might be useful in early-prevention of some types of precancerous cells and a total inhibition of this might make one liable to develop something even worse :freaked2: than male pattern baldness in later life.

Im of the opinion that DHT inhibiton (finasteride) and a good amount of anti-oxidants and good nutrition in general are about all that can be safely done from an internal standpoint for pattern baldness at this point until we know more. I see some guys following Immortal Hairs regimine taking all sorts of supplements like perilla leaf oil, etc. in high amounts hoping to internally inhibit things like TGF beta totally and completely and openly wonder how these men's health will be affected 20 years down the line?


I was "hoping" that perhpas this tea compound could inhibit androgen receptors from a topical standpoint.........................and perhaps they can still despite staining the scalp, as we dont know how much gets absorbed. Its something that would just obviously have to be tested, but it is promising that such a compound exists and can be isolated (surely) if need be, and from a plentiful source (tea). Its good news for male pattern baldness sufferers no matter how one looks at it.

 

[CCS]

Everyone should carefully monitor how much green and black tea they drink. They both have high concentrations of fluoride in them. Fluoride is incredibly toxic to the thyroid gland. If you or any immediate family members have ever had thyroid problems, I'd probably steer clear of both large amounts of tea and large amounts of soy products.

It's pretty tough to fight male pattern baldness when you have an underlying thyroid disorder, as well.

Remember, everything in moderation.

what about GTE? Is that bad? I'm glad I'm lazy with my supplements. They last me forever and I don't over dose. I try to take a little of everything.

 

[Bryan]

Re: Black tea compound, blocks alpha 5 reductase, and A-rece

Theaflavin-3,3'-digallate and penta-O-galloyl-ß-D-glucose inhibit rat liver microsomal 5-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells.

I've had a similar study lying around here for years, showing that even EGCG from green tea downregulates the production of androgen receptors in LNCaP prostate cancer cells, but I think that needs to be interpreted with caution. There's no guarantee that hair follicle cells would react the same way as prostate cancer cells, in that specific regard.

 

[Artista]

I drink a lot of tea too--- to bad it does squat.

How do you know it does squat?

I grew up on black strong tea. It's had 40 years to do something and nada! :evil:

 

[michael barry]

Bryan wrote:

I've had a similar study lying around here for years, showing that even EGCG from green tea downregulates the production of androgen receptors in LNCaP prostate cancer cells, but I think that needs to be interpreted with caution. There's no guarantee that hair follicle cells would react the same way as prostate cancer cells, in that specific regard

That was something I was concerned about in regards to these compounds. However, its inhibition of alpha five reductase enzymes should seemingly translate should it not? I mean 5AR is 5AR to my knowledge. Also, the male pattern baldness-research article mentioned black tea as one of the compounds that inhibit TGF-beta. It was in a Paul Mitchell Shampoo of some kind.



ON a related note:
Look at the ingredient of this Paul Mitchell THICKENING SHAMPOO:
Lemon Sage Thickening Shampooâ„¢
ENERGIZING BODY BUILDER
Thickens – A unique blend of thickening agents boost volume and thicken limp locks
Strengthens – Panthenol strengthens damaged hair and reduces the formation of split ends
Energizes – Natural extracts of lemon, sage, peppermint and tea tree stimulate the senses and provide an energizing experience

SIZES (OZ.): 3.4, 10.14, 33.8

Lemon Sage Thickening Shampoo
was voted Best New Volumizing Shampoo by SELF Magazine’s Healthy Beauty Awards


That is from here:http://www.paulmitchell.com/Products/TeaTree/Care/Pages/LemonSageThickeningShampoo.aspx




....................and from Paul Mitchell's Tea Tree Shampoo,
http://www.paulmitchell.com/Products/Telogen Effluvium ... ampoo.aspx

Stimulates – The combination of tea tree oil and peppermint create a cooling tingle[quote:a8dbe]



Notice anything? Peppermint is in both............................like I said its an anti-androgen and if it was bad for hair, it would not be popping up in these products (like Alpecin, Jason's shampoo, Tricomin Shampoo and conditioner, etc.) over and over again.

[/quote:a8dbe]

 

[ripple-effect]

Does sweet tea count? LOL

 

[retropunk]

Does sweet tea count? LOL

You must be from the Southern US. No one else really calls it sweet tea

 

[wookster]

Everyone should carefully monitor how much green and black tea they drink. They both have high concentrations of fluoride in them. Fluoride is incredibly toxic to the thyroid gland. If you or any immediate family members have ever had thyroid problems, I'd probably steer clear of both large amounts of tea and large amounts of soy products.

It's pretty tough to fight male pattern baldness when you have an underlying thyroid disorder, as well.

Remember, everything in moderation.

:freaked: :freaked: :freaked:

http://curezone.com/dental/fluoride.html

1951 The February 10, 1951 issue of JAMA Medical Literature reports the following symptoms of chronic fluoride poisoning, stating "Chronic intoxications resulting from prolonged intake of smaller amounts of fluorides include dental fluorosis. Fluoride also tends to accumulate in bones, leading to hypercalcification and brittleness. Ligaments and tendons also become calcified. Serious symptoms may ensue, such as loss of mobility of joints, easy fractures and pressure on the spinal chord. Other effects include baldness in young men, accompanied by increased fluoride concentrations in hair and nails, anemia and decreased blood clotting power due to the binding of calcium. Dysmenorrhea, alterations in growth and weight, lowered birth rate, high incidence of fractyre, thyroid alterations and liver damage have been observed in regions of endemic fluorosis."