best minoxi vehicle ???

[Jacob]

There are some examples in this older thread: http://www.hairlossfight.com/forums/viewtopic.php?f=1&t=228

Here's the one talking about less minoxidil needed in a lipo/nano-type vehicle compared to a regular vehicle:

BLOCK-COPOLYMER NANOPARTICLE FOR FOLLICULAR DELIVERY OF HAIRDRUGS

Won-seok Park, Jong-won Shim, Dae-seok Sung, Dae-kwon Kim, Chang-hoon Lee, Yong-chul Shim

AmorePacific R&D Center, Yongin-si, Korea

The hair follicle is acknowledged to be a complex, dynamic structure which may contribute significantly to passive transport of compounds into the scalp. To elucidate the improved delivery of hair drugs such as minoxidil and cyclosporin A(CsA) with the use of nanoparticles, we developed a follicular delivery system based on the self-assembled block-copolymer(PCG-101) nanoparticle.

Self-assembled nanoparticles and phosphatidylcholine liposomes (330 nm) containing minoxidil & CsA were prepared. The distribution pattern of fluorescence dye (rubrene), entrapped in block-copolymer and liposome, was observed in dorsal guinea pig skin and hamster ear using confocal microscopy. The two penetrated drugs were measured using the Franz diffusion cell with rodent skins. Also, the anagen induction & elongation activities of the two drugs, entrapped in nano-particles, were observed using female C57bl/6 mice in the telogen phase.

We observed that insoluble rubrene fluorescence dye, entrapped in nanoparticles, penetrated via the pilosebaceous pathway in guinea pig skin and hamster ear region. In the Franz cell experiment, minoxidil, which was entrapped in nanoparticles of the 40 nm size, diffused significantly more in hairy guinea pig skin +/- by 1.8~2.4 fold +/- compared to those in liposome and ethanol solution. There was no significant difference in the activity of anagen induction of C57BL/6 mouse between 3 % minoxidil solution (propylene glycol and ethanol) and 0.5 % minoxidil nanoparticle solution. Also, the same dose (0.2%) of CsA, entrapped in nanoparticles, showed higher activities of anagen elongation compared to CsA dissolved in ethanol & polyol solution.

On the basis of in vitro and in vivo experimental models, block-copolymer nanoparticles can be effectively used as a permeation shunt system via pilosebaceous units in substitution for liposomes.

Divine Skin/Spectral says this about it:

Nanosomes are microscopic lipospheres that deliver active ingredients deeper into tissues. Much smaller than human skin cells, they encapsulate compounds within microspheres of material similar to skin to reach deeper than standard carriers and boost the effectiveness of active ingredients.

 

[RK85]

In forums we talked about DMSO as a good system to reach inside the skin years ago. You can use the search option.
If I remember correctly minoxidil and retinA is inestable when we use together.

So how much time you have to wait (from the moment of using Minoxidil) before you can use the Retin-A?

Do you agree that Minoxidil should be used around 30 minutes after Retin-A?

It needs to be specifically Tretinoin or Retin-a, in either .025% or .05% concentrations. The creme is very effective, but the gel absorbs even better. Just be careful, and watch for signs of irritation. To avoid sun exposure, I apply a pea-sized dab every other night, and then minoxidil around 30 minutes later for maximum absorption and efficacy. Don't be surprised if your scalp peels some skin.... this is completely normal.

http://www.hairlosstalk.com/interact/archive/index.php/t-24318.html

 

[Armando Jose]

Please seek in google minoxidil and spumil, the first ocurrence is the product I talked to you