Attenuation Of Dkk1-induced Hair Growth Inhibition In Cultured Human Hair Follicles By Tianeptine

[Kornel]

Here's the link to the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318505/.

Has anyone (who tried tianeptine) found any impact on hair?

 

[kiwipilu]

nice find;
"These data, together with promotion of viability of DP cells and upregulation of growth factors such as IGF-1, HGF, VEGF, and KGF, suggest that tianeptine or its derivatives may have potential for treating and preventing hair loss by regulating human hair cycling."

 

[Kornel]

But we still need more data.

Tianeptine is unfortunately highly addictive, so we can only try it topical.

BTW Has anyone tried any form of dkk1 inhibitors? Any results?

 

[kiwipilu]

what's surprising is I see some people using the drug on few forums as antidepressant (oral obv) : they
speak of hair thinning. So maybe it could depends on dose and way of delievering it. like you say topical.. that said I doubt people have already tried this angle for male pattern baldness, because we know nothing about it; side effect, long run efficiency(or does it make things worse)... etc .russian roulette.
other study https://www.ncbi.nlm.nih.gov/pubmed/23581888

 

[Kornel]

Yeah, I also saw mixed opinions on depression forums, so it's too risky.

Androgens still seem to be the only proven culprit and factor.