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Ohh...the commercial name is Prostaquinone, if you're going to search it there.
Any One Ever Tried Prostaquinone??........
- Thread starter ahmad029
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it counters hairloss through several mechanisms
1. it inhibit IL-6 https://www.ncbi.nlm.nih.gov/pubmed/20880395 which is shown to repress hair growth due to increase in DHT https://www.ncbi.nlm.nih.gov/pubmed/21881585
2. it antagonize Crth2 pathway. which is shown to induce PGD2 which is bad for hair.
3. it also inhibit androgen receptor " thymoquinone inhibited growth of C4-2B-derived tumors in nude mice. This in vivo suppression of tumor growth, as with C4-2B cell growth in culture, was associated with a dramatic decrease in AR, E2F-1, and cyclin A as determined by Western blot of tissue extracts." https://www.ncbi.nlm.nih.gov/pubmed/17699783.
3.it also inhibit JAK/STAT pathway we know that JAK inhibitors are cure for Alopecia areata and a company is trailing it to treat Androgenetic Alopecia. https://www.ncbi.nlm.nih.gov/pubmed/20880395.
4. some one recently posted a study about PAK-1 inhibition increase hair growth. well thymoquinone inhibit PAK-1.
@InBeforeTheCure @Swoop @hellouser you guys know more science than me.what do you interpret could it be a potential treatment.
Unfortunately it down regulates VEGF which is not exactly helpful for hair growth (http://www.sciencedirect.com/science/article/pii/S221052391200027X)
The composition of the essential oil will roughly be like this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551137/table/Tab1/
Unfortunately 7-17% or so is thymol which is a COX-1 & 2 inhibitor so the essential oil is a waste of time really.
If you want to try an essential oil I suggest peppermint oil which has worked well for me.
The composition of the essential oil will roughly be like this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551137/table/Tab1/
Unfortunately 7-17% or so is thymol which is a COX-1 & 2 inhibitor so the essential oil is a waste of time really.
If you want to try an essential oil I suggest peppermint oil which has worked well for me.
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Keep in mind this is a zebrafish model study.
There's another one done on mice if you google for it, the point being I doubt it is some wonder drug.
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@ahmad029 Don't know anything about prostaquinon, but when evaluating whether some substance might work, look at the mechanism. If the effect is demonstrated in cells of the hair follicle (such as the PAK1 study), then that's great. If the study is in some other cell type, and the mechanism is a direct interaction with the protein, then probably it will work in hair follicles too. If the substance affects a pathway by activating or inhibiting expression of a gene, it's much less certain. This is because transcription factor target genes are quite cell-type specific (though there is some overlap between cell types), so if substance X inhibits transcription factor Y which activates expression of gene Z, it's far from certain that substance X's affect on gene Z will be the same in a different cell type than the one it was tested in.
this is a drug that protect your body from every front "anti oxidant" , "anti inflammatory" , "anti histamin" , "anti viral" , "anti bacterial" " neuro protective".
well if you said this 1400 years ago it would be because of your belief but now there is evidence its Bro science.
thanks for educating me, i also suggest to look in to it if you can, although its a anti proliferative and pro-apoptotic substance toward cancer cells.
but it protects normal cells very well maybe it can completely maintain what we have by protecting DP cells from whatever causing this damage.
You could attribute those properties to 100s of other studies on other naturally occurring compounds, look back here over the last 10 years, there are many to choose from.