Any Evidence For Post Finasteride Biochemical Changes?

Gone

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Besides complaints of persisting side effects I mean. The PFS foundation is reportedly conducting studies but I don't think their results are published yet. I hear some people say that post finasteride users have just as much serum DHT and a slightly higher or lower androgen activity; not much different from a non-finasteride user. I think the study that this website indirectly refers to is what these people are talking about.

https://www.healthunits.com/news/finasteride-is-not-causing-sexual-dysfunction/

What I would be interested in is a study comparing activity levels of type 1 and 2 5-alpha reductase, and AR content in certain tissues. I do think it's relevant that the most common persistent side effect of finasteride is sexual dysfunction, which is also the most easily induced by depression. I'm not trying to discount this though. I also think that every side effect in the book is totally possible when you're on the medicine, but permanent effects are my primary focus here.

Personally I think that penile tissue differences, gynecomastia, type 1 and 2 5AR, estrogen levels, ER receptorial activity would be helpful markers of PFS. These examples would be better correlated to finasteride than just sexual dysfunction because impotence can have other causes.

Are there any other studies looking at such topics? This thread is just a request for compiling actual studies on post finasteride symptoms specifically.
 

Gone

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I will post this in the anti-androgen section as well. This can be deleted if need-be
 

saymsaym

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Hello,

This study made by Merck states that "circulating levels of testosterone and estradiol were increased by approximately 15% as compared to baseline, but these remained within the physiologic range.". It was assessed after 24h.

Can't think about other scientific studies around these specific topics as very often the target is sexual dysfonction only.

There is an article on HLC about estrogen/estradiol and testoterone issues regarding finasteride.

Have a nice evening day
 
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