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EP(4) is also involved in bone growth. Histamine is a beta-catenin
agonist. The possible activation of NFKB is rather a surprise.
Peptides. 2005 May;26(5):707-11. Related Articles, Links
Click here to read
Anti-alopecia mechanisms of soymetide-4, an immunostimulating
peptide derived from soy beta-conglycinin.
Tsuruki T, Takahata K, Yoshikawa M.
Division of Food Science and Biotechnology, Graduate School of
Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Previously, we found that orally administered soymetide-4 (MITL), an
immunostimulating peptide derived from soybean beta-conglycinin alpha'
subunit, suppressed alopecia induced by the anti-cancer drug etoposide
in neonatal rats. Soymetide-4 has weak affinity for
N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor. fMLP showed an
anti-alopecia effect after intraperitoneal administration, though it was
inactive after oral administration. Anti-alopecia effect of fMLP was
blocked by pyrilamine or cimetidine, antagonists for histamine H(1) or
H(2) receptor, respectively. However, the anti-alopecia effect of
soymetide-4 was not inhibited by the histamine antagonists but by
indomethacin, an inhibitor of cyclooxygenase (COX), or AH-23848B, an
antagonist of the EP(4) receptor for PGE(2). Anti-alopecia effect of
soymetide-4 was also blocked by pyrrolidine dithiocarbamate, an
inhibitor of nuclear factor-kappaB (NF-kappaB). These results suggest
that PGE(2), which is produced after activation of COX by soymetide-4,
might suppress apoptosis of hair matrix cells and etoposide-induced
alopecia by activating NF-kappaB.
PMID: 15808899 [PubMed - in process]
agonist. The possible activation of NFKB is rather a surprise.
Peptides. 2005 May;26(5):707-11. Related Articles, Links
Click here to read
Anti-alopecia mechanisms of soymetide-4, an immunostimulating
peptide derived from soy beta-conglycinin.
Tsuruki T, Takahata K, Yoshikawa M.
Division of Food Science and Biotechnology, Graduate School of
Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Previously, we found that orally administered soymetide-4 (MITL), an
immunostimulating peptide derived from soybean beta-conglycinin alpha'
subunit, suppressed alopecia induced by the anti-cancer drug etoposide
in neonatal rats. Soymetide-4 has weak affinity for
N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor. fMLP showed an
anti-alopecia effect after intraperitoneal administration, though it was
inactive after oral administration. Anti-alopecia effect of fMLP was
blocked by pyrilamine or cimetidine, antagonists for histamine H(1) or
H(2) receptor, respectively. However, the anti-alopecia effect of
soymetide-4 was not inhibited by the histamine antagonists but by
indomethacin, an inhibitor of cyclooxygenase (COX), or AH-23848B, an
antagonist of the EP(4) receptor for PGE(2). Anti-alopecia effect of
soymetide-4 was also blocked by pyrrolidine dithiocarbamate, an
inhibitor of nuclear factor-kappaB (NF-kappaB). These results suggest
that PGE(2), which is produced after activation of COX by soymetide-4,
might suppress apoptosis of hair matrix cells and etoposide-induced
alopecia by activating NF-kappaB.
PMID: 15808899 [PubMed - in process]
