Yes, but the dual application (one after another) approach is terribly inconvenient, and my scalp hates creams but loves liquids. I think the above posts help point out how the suppliers of hair loss products can use their weight to influence the science. I have absolutely nothing against Dr. Lee or any of the apothecaries, but since a monthly minoxidil/spironolactone mixture cannot be sold due to their inevitable reacting with one another, anyone in the business would necessarily recommend such a dual application. They also get the bonus of being able to sell the hair loss consumer two different products, when a potentially simpler and less irritating one might suffice.
Let me explain what I mean, if it’s not clear. Obviously, with the dual application approach, spironolactone and minoxidil still do contact and mix with one another for T minus 20 min. so it would seem their mixing presents no problem at all in the short period of time for absorption. Otherwise, there wouldn’t be the instructions of applying the spironolactone 20 min. after the minoxidil, but rather several hours afterward. I realize the spironolactone cream in theory is supposed to form a protective band around the minoxidil to aid its absorption, but still. I guess this question is best suited to the amateur chemists or pharmacologists around here. Perhaps it’s a very simple question. Will the crushed spironolactone significantly jeopardize the activity of 5% minoxidil?
As an experiment, I dissolved 25mg spironolactone tablet in 1mL 5% minoxidil. After more than an hour, there was still no odor. Having left some wet spironolactone pills around, I am familiar with the horrific dead animal odor.