OverMachoGrande
Senior Member
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Ladies and Gentlemen this is The Big One!!!
Sex hormone binding globulin (S.H.B.G.) increases the bioactivity of androgens and estrogens and reduces their metabolic clearance or excretion, meaning; when androgens are stuck to S.H.B.G. not only are they still active, but also their bioactivity is prolonged! Remember, the stronger the androgens, the stronger they stick to S.H.B.G., which is stuck to the receptors. Also keep in mind that estrogens bind to S.H.B.G. a lot less than androgens and D.H.T. binds a lot more than testosterone!!
Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.Schöttner M, Spiteller G, Gansser D.
Lehrstuhl für organische Chemie, Universität Bayreuth, Germany.
The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.
PMID: 9461660 [PubMed - indexed for MEDLINE]
The post above claims that lignans interfere with D.H.T. binding onto S.H.B.G. meaning; D.H.T. is then excreted via the metabolic clearance. So the more testosterone is stuck onto S.H.B.G. and the less D.H.T. that is stuck to S.H.B.G. would be ideal...right, because S.H.B.G. would be prolonging the effects of testosterone and not D.H.T.
Now I did read somewhere that when estradiol binds with S.H.B.G. it activates IGF-1...Could this not only be the cure to male pattern baldness but also breast and prostate cancer?!
So an increase of testosterone attached to S.H.B.G. and a reduction of both estradiol and D.H.T. attached to S.H.B.G. would be ideal. Flax seeds and major lifestyle changes would be a huge step in the right direction.
Sex hormone binding globulin (S.H.B.G.) increases the bioactivity of androgens and estrogens and reduces their metabolic clearance or excretion, meaning; when androgens are stuck to S.H.B.G. not only are they still active, but also their bioactivity is prolonged! Remember, the stronger the androgens, the stronger they stick to S.H.B.G., which is stuck to the receptors. Also keep in mind that estrogens bind to S.H.B.G. a lot less than androgens and D.H.T. binds a lot more than testosterone!!
Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.Schöttner M, Spiteller G, Gansser D.
Lehrstuhl für organische Chemie, Universität Bayreuth, Germany.
The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.
PMID: 9461660 [PubMed - indexed for MEDLINE]
The post above claims that lignans interfere with D.H.T. binding onto S.H.B.G. meaning; D.H.T. is then excreted via the metabolic clearance. So the more testosterone is stuck onto S.H.B.G. and the less D.H.T. that is stuck to S.H.B.G. would be ideal...right, because S.H.B.G. would be prolonging the effects of testosterone and not D.H.T.
Now I did read somewhere that when estradiol binds with S.H.B.G. it activates IGF-1...Could this not only be the cure to male pattern baldness but also breast and prostate cancer?!
So an increase of testosterone attached to S.H.B.G. and a reduction of both estradiol and D.H.T. attached to S.H.B.G. would be ideal. Flax seeds and major lifestyle changes would be a huge step in the right direction.
