5AR-1 converted DHT vs 5AR-2 converted DHT (finasteride & dutasteride)

[BaldingHelpMe]

Is there a difference between 5AR-1 converted DHT vs 5AR-2 converted DHT in genetic hair loss? Or DHT is DHT, no difference? Will they both attack the hair follicles?

Where are these enzymes produced? Are they produced in different organs? If 5AR-2 is inhibited, will organs produce more 5AR-1 instead?

 

[kuca]

5AR-2 is only responsible for hair loss, while 5AR-1 is not having imapact on hair loss, dutasteride inhibts both hormons while finestere inhibits only 5AR-2.

 

[BaldingHelpMe]

5AR-2 is only responsible for hair loss, while 5AR-1 is not having imapact on hair loss, dutasteride inhibts both hormons while finestere inhibits only 5AR-2.

But is there a difference between 5AR-1 converted DHT and 5AR-2 converted DHT?

 

[kuca]

I know that 5-Ar1 is mostly presented in sebum glands,also it s presented in brain, and 5-Ar2 is presented in hair foliculs

 

[Armando Jose]

DHT is DHT, ....

 

[BaldingHelpMe]

DHT is DHT, ....

But the enzyme that converts testosterone is different... shouldn't the resulting end-product be different?

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I know that 5-Ar1 is mostly presented in sebum glands,also it s presented in brain, and 5-Ar2 is presented in hair foliculs

5AR1 is produced in sebum glands, but it will convert the testosterone to DHT, then enter into bloodstream, and eventually entering the hair follicles. So will the said DHT also attack the hair follicles?

 

[Armando Jose]

But the enzyme that converts testosterone is different... shouldn't the resulting end-product be different?



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5AR1 is produced in sebum glands, but it will convert the testosterone to DHT, then enter into bloodstream, and eventually entering the hair follicles. So will the said DHT also attack the hair follicles?

No, the product is the same: DHT. maybe the concentration of it can change but the product is the same.

 

[BaldingHelpMe]

No, the product is the same: DHT. maybe the concentration of it can change but the product is the same.

If they are the same, then when taking finasteride, there will still always be some DHT left to attack the hair follicles?

Also, according some studies: http://www.endocrine-abstracts.org/ea/0019/ea0019p136.htm, inhibiting 5aR-1 enzyme promotes insulin resistance, if they are the same, why would inhibit 5aR-1 promotes insulin resistance but not inhibiting 5aR-2?

 

[Armando Jose]

Finas acts mainly in 5aR-2 type

Good question about insulin resistance and 5aR's. It is interesting but I dont know the answer, perhaps this study could help.
http://diabetes.diabetesjournals.org/content/63/10/3180.full

 

[kuca]

finasteride inhibits dht2 by 90% and usully that is enough to stop male pattern baldness, remember that even children and womens have some amount of dht in blood but thay don t have male pattern baldness, so inhibiting 90 % dht2 should stop male pattern baldness