12 Month Update - Questions about Avodart

[bombscience]

Hey everyone, it's been a while, not sure who remembers me but I'm back to provide my update at 12 months.

I'm still losing hair and my situation is the worst it's been. I can't say at any point over the last year i've noticed my hairloss speed up or slow down. All I know is that I've been consistantly losing hair at the same rate that I was before I started treatments.

About 2 months ago I stopped using minoxidil because I continued to thin while using the product and my scalp was always itching. Since then I've noticed a fairly slight increase in my hairloss, but not too much. That's discouraging becuase minoxidil never helped me regrow hair to begin with. So I did 11 months of minoxidil, 12 months on 1mg Finasteride with no results. 8 of those on Folligen with no results. 6 of those on 2% spironolactone with no results. All of those on Nizoral 3x week.

For the last 2 months my regimen has been:

1mg Finasteride Daily
2% spironolactone Mornings
5% spironolactone Nights
Folligen 3-4 times a week
Grape Seed Extract and Multivitamen

Observations:
Thinner hair, same irritation as before with the minoxidil.

At this point I'm wondering if I'm actually encouraging my hairloss. What can be done now, any suggestions?

Obviously I'm thinking about dutrasteride/avodart. Anyone step up to dutasteride and have success after lackluster results with finasteride? Also, I hate to do this as a veteran poster, but if someone could reccomend a reliable place with semi-fast shipping to order REAL Avodart from, I would be eternally greatful. I spent 15 minutes searching before I asked that question .

 

[Kevin fretwell]

Sorry to hear about your dissappointing results but there seems to be a number of posters who didn't get anything either .May I suggest dr Lee's 15% min and the itching will get bad but that can be taken care of with applying a copper peptide product (revitalize crew)a couple of hours after application of min .Upon adding a cp product get rid of the nizoral . not needed along with cp and replace the use of nizoral with another shampoo maybe nano or hair energizer (16$) ect ect and use it everyday and let sit for 10 minutes before rinsing !This approach is a bit of a hastle but the less expensive than avodart and kicks *** .Don't spend your money on a cp shampoo because you already got that front taken care of .I don't use 15% because I get heart angina from it so I stick with 5% .

 

[bombscience]

Sorry to hear about your dissappointing results but there seems to be a number of posters who didn't get anything either .May I suggest dr Lee's 15% min and the itching will get bad but that can be taken care of with applying a copper peptide product (revitalize crew)a couple of hours after application of min .Upon adding a cp product get rid of the nizoral . not needed along with cp and replace the use of nizoral with another shampoo maybe nano or hair energizer (16$) ect ect and use it everyday and let sit for 10 minutes before rinsing !This approach is a bit of a hastle but the less expensive than avodart and kicks *** .Don't spend your money on a cp shampoo because you already got that front taken care of .I don't use 15% because I get heart angina from it so I stick with 5% .

15% is an option yes, but I'm looking to stop hairloss first, and then try to regrow. 5% minoxidil just didn't work for me, so i know i'm not a good responder to minoxidil. I will consider 15% if I can't get things under control in 6 months.

 

[Bismarck]

Bombscience, you have tried an impressive regimen. Do you think that you just not respond to the treatment. Or are you one of those guys whose hairloss is that aggressive that they go from Norwood 2 to Norwood 5 in 2 years ?

BISMARCK

 

[bombscience]

Bombscience, you have tried an impressive regimen. Do you think that you just not respond to the treatment. Or are you one of those guys whose hairloss is that aggressive that they go from Norwood 2 to Norwood 5 in 2 years ?

BISMARCK

maybe 2-5 in 3 years, hopefully but i'm a diffuse thinner so it's really going to suck.


i went from about a Norwood .5 to a Norwood 2 this year while ON treatments.

 

[Bismarck]

Strange... I've heard of many who had only very moderate temples for a long time and had an massive hairloss after starting the treatment. The question whether minoxidil or finasteride can worsen hairloss has never been satisfactory ansewered. I which I could help you....

BISMARCK

 

[Slartibartfast]

Hey everyone, it's been a while, not sure who remembers me but I'm back to provide my update at 12 months.

Welcome back bomb.

Obviously I'm thinking about dutrasteride/avodart. Anyone step up to dutasteride and have success after lackluster results with finasteride?

To summarise - twenty months of finasteride/minoxidil could only slow my frontal loss so last May I dropped finasteride for 0.5mg dutasteride every other day and, after a very bad shed during months 6 - 7, the first couple of inches in from my hairline are finally improving. A lot of the hairs are still quite thin but gradually they're getting longer/thicker/darker - fingers crossed that they continue to do so. Whether dutasteride every other day would work for you as well I'm not sure as your results whilst on finasteride/minoxidil sound considerably worse than mine.

Also, I hate to do this as a veteran poster, but if someone could reccomend a reliable place with semi-fast shipping to order REAL Avodart from, I would be eternally greatful. I spent 15 minutes searching before I asked that question .

Well, in return for your eternal gratitude I can suggest internationalpharmacy.com from whom I've been ordering this past year and qhi.co.uk who I recently found and am considering switching to. I'm not sure of the import restrictions or prescription requirements for shipping to the US but if you can get round any of these then one of those two sites should serve you well.

Good luck,
Slarti

 

[avri]

Upon adding a cp product get rid of the nizoral

Why?


avri

 

[JJ Gittes]

Bombscience,

like you I'm a diffuse thinner (good hairline and thanks to finasteride, good crown). It's the area in between that's heading south.

I've been using Lee's 15% minoxidil for over 4 months now (after 4 years of 5% use), and my hair has categorically gotten worse. :-x

Obviously, you don't want to base your decision strictly on my poor outcome, but I've yet to read any posts on this forum or elsewhere where the user experienced positive results with this 15% stuff.

Somebody please correct me if I'm wrong.

 

[Yardbird]

Bomb, I am wondering about Proxiphen-n in your case since it seems that irritation could be the source of your thinning. I haven't tried it, but who knows? I've read that Proxiphen-N is designed especially for irritation since that's Proctor's take on why people go bald, at least as I understand it.

 

[youngguy_uk]

dont drop nizoral. bad advice. nizoral was used in all the finasteride trials. its shown up as being good in conjunction with finasteride. just leave it and trust in some science. all this american crew stuff hasnt been involved in fda trials. if youre serious about stopping your hairloss, dont get desperate and try all the seriously unproven gobbledygook, get strict and attack the hairloss from different angles. at least use reliable methods, even if they havent been fda tested.

tried tricomin? theres an option. might want to hold off on the 15% minoxidil to see if you can stop the loss using avodart first. from what ive read it sounds better using a high avodart doseage regularly to combat the loss but if you get major sidies change the doseage. youll want to try and get max benefit from avodart, but speak to someone who knows more about it and is on it. hey, at least youve got minoxidil 15% to boost your hair if you really need it in time, huh? good luck, keep your head up and your scalp in god condition. there are still options.

 

[Cassin]

dont drop nizoral. bad advice. nizoral was used in all the finasteride trials. its shown up as being good in conjunction with finasteride. just leave it and trust in some science. all this american crew stuff hasnt been involved in fda trials. if youre serious about stopping your hairloss, dont get desperate and try all the seriously unproven gobbledygook, get strict and attack the hairloss from different angles. at least use reliable methods, even if they havent been fda tested.

tried tricomin? .

nizoral wasn't used. T/GEL was.

Your bashing Amercian Crew but supporting Tricomin?

It's the same stuff dude.

Tricomin made it through 2 phases of the FDA. Neither nizoral nor T/GEL has made even begun to do either, nor will they.

Copper-Peptides are the real deal.

 

[Cassin]

By the way YGUK

I'm not slamming you at all but posting a follow up....just a friendly correction.

The more and more I read about Copper-Peptides, the more I think people will start hopping on it down the road......with good reason.

Copyright 1997, Reuters News Service KIRKLAND, Wash., April 4 /PRNewswire/
ProCyte Corporation (Nasdaq-NNM: PRCY) today said that it obtained statistically significant results in an initial study of its hair growth compound, PC1358, in a group of men, ranging in age from 18 to 40 years old, with male pattern hair loss. The early-stage Phase II clinical study of the company's investigational compound, tradenamed Tricomin(R) solution, enrolled 36 men with early to mid-stage androgenetic alopecia -- or male pattern hair loss. Thirty-three of the participants were evaluable in the study, in which they were randomly assigned to either one of two dose groups or the vehicle formulation. Study participants topically applied the assigned treatment twice a day for 24 weeks.

The study's prospectively designed endpoints included determination of the effect of 1.25% and 2.5% doses of PC1358 versus vehicle on total hair count and hair weight measured in a one square centimeter treatment area located on the top of the head. An additional endpoint included a general cosmetic assessment of the treated area. Treatment with 2.5% PC1358 resulted in a statistically significant increase in the total hair count when compared to vehicle treatment over the course of the study. Appreciable increases in total hair weight were not found over the treatment phase of the study.

In the general cosmetic assessment, all participants treated with the high dose compound believed they were either growing more hair or staying the same, while almost half of the vehicle-treated participants believed they were losing more hair over the course of the study. The Phase II single center, double-blinded study also provided a further safety assessment of the compound. There were no serious drug-related adverse events reported in the study.

PC1358 is a copper peptide compound. While the specific mechanism of action of the compound is not known, in vivo and in vitro studies have shown this class of compounds to be pharmacologically active in stimulating and protecting hair follicles. Additional studies have shown that PC1358 stimulates the synthesis of major extracellular matrix components involved in hair follicle regulation.

ProCyte Corporation is a development stage healthcare company that is developing a class of proprietary copper peptide compounds for wound care, tissue repair and related applications.

SOURCE ProCyte Corporation
CONTACT: Karen L. Hedine, Vice President of ProCyte

 

[Kevin fretwell]

Good point mentioning that nizoral was in finasteride trials .despite my resent dismay for nizoral I have to say keep it for it was in the trials .

 

[Cassin]

Good point mentioning that nizoral was in finasteride trials .despite my resent dismay for nizoral I have to say keep it for it was in the trials .

Why does everyone think Nizoral was used?

... or placebo, were instructed to use a specified, medicated, tar-based shampoo (Neutrogena
T/Gel®** Shampoo) during the first 2 years of the studies. There were ...

http://www.fda.gov/cder/foi/label/2002/20788S4lbl.pdf

 

[Yardbird]

Actually HairLossTalk.com's article this month on Nizoral explains why Nizoral was not used. One of the main reasons is that it not only deals with inflamation, but it's an antiandrogen. Therefore, Nizoral grows hair on it's own, preventing researchers from measuring the effects of finateride alone.

http://www.hairlosstalk.com/newsletter/article252.htm

 

[HairlossTalk]

Why does everyone think Nizoral was used?

Probably because people like me have been saying "A shampoo like Nizoral was used..." for several years now. One thing you learn running a site is that people don't always get the whole message

HairLossTalk.com

 

[Guest]

What strength Nizoral did they use in the trials? :uglylol:

Ty