Recent content by PrinceWilliamThe2nd

It's weird that they want to go straight to humans from the pre-clinical work in mice. You would assume that they would also do a pre-clinical study in NHPs (non-human primates). Maybe I'm missing something here though. The way Tsuji is asking for money now and the fact that the twitter channel...

Naive question, but isn’t the main point of this antagonist to reduce the side-effects we get from finasteride, i.e. sexual side-effects? Shouldn’t they be looking into the change of systemic testosterone/DHT levels over a longer period of time to proof that point? In the study design there is...

Yes

Study results have been posted: https://www.clinicaltrialsregister.eu/ctr-search/trial/2015-002877-40/results#endPointsSection No differences between topical and oral finasteride: Looks like they did not characterize systemic DHT levels. Instead they conducted a questionnaire - yes, a...

Almirall's code for this is now ALM12845: https://www.almirall.com/en/about-almirall/research-and-development/pipeline/

I agree, the pharma industry is a clusterfuck!

That was a preliminary study. The paper below is more relevant, where they only dosed 0.2275mg topically and saw 52% reduction in scalp DHT, but only 24% reduction in serum DHT levels. Their topical solution does seem to have a better safety profile than the 1mg tablet once a day, which reduces...

Hehe, George Cotsarelis is actually a big name in the field of hair follicle research. The science behind what you are doing is e.g. further explained in one of his talks and a highly cited paper from his group.

You mean something like this? http://www.follicabio.com ;)

Anything new here?

This must be Fidia's reporting structure, all this bullshit this Brotzu Mofo has pulled of the past 2 years could only be explained that way: Gomorrha ↑ Fidia ↑ Brotzu ↑ Beps63 How did this guy become a doctor? I don't even want to know how many people must have died because of this...

From a Norwood 5.00001 to 5.00000, Awesome... NOT!

It's just a general time line for drugs that are seeking approval, not specific for P-3074. Things might be a little faster here, as this is just a reformulation and not an actual new drug Polichem is trying to bring to market here. Though, I personally doubt that we will see this in shelfs...

Just found this: So, looks like we have to wait another 0.6-2 years until we can get this, if the FDA eventually approves it. I am wondering if this will be over the counter like minoxidil.

Might want to give this paper a read if you are interested in the science behind it: "Pharmacologic inhibition of JAK-STAT signaling promotes hair growth" Full paper here: https://pdfs.semanticscholar.org/67ac/836041a1f7a4e912f1254d79f5bfa5d93d63.pdf