Recent content by Pancreata

In theory topicals should be superior oral route for exposure and uptake by target cells, but this would need to be tested side by side in the case of FN. In the end what matters more than route is efficacy weighed against sides - feminization is a real issue for some men and there is data in...

Biochemist here. I am sorry but it is you that is completely wrong. Topical FN suppresses systemic DHT as strongly as 1 mg oral FN. Only when you reduce the 0.25% topical to 0.1ml in volume which is a 0.25 mg dose, do you see less reductions in systemic DHT. The original studies of FN showed at...

I stopped 3 weeks ago and am also experiencing excessive loss. More than before starting treatment. I agree with your thinking that there is now unopposed DHT, albeit probably with higher basal DHT concentrations or increased androgen signaling in response to the weeks of binding to DHT by...

DNA mutates, not RNA. You got the rest correct.

Trinov RIP.

Everyone please email your side effects and complaints to Fidia and Francesca Consolaro the corresponding author on the Fidia Trinov proof of concept research paper. info@fidiapharma.it f.consolaro@outlook.it

I am also experiencing massive shedding. I cannot wait to see if this is going to eventually become new hair growth. I completely agree with initiating a class action complaint against Fidia. I have not doubt they suppressed all the sides and shedding in their studies, If it is happening to so...

Yes you understand correctly. S-equol binds to DHT with high affinity and if the scalp is deprived of DHT, it makes complete sense biologically that androgen receptor and testosterone would increase in response. If your genetic endowment dedicates hair loss, a little s-equol is not going to...

One more point and maybe as important. The journal that Fidia published their Trinov study is a third tier journal by publishing standards (Impact factor 1.53) and is loaded with Italian scientists on the Editorial Board. Not surprisingly one publishing strategy is to submit weak data to a...

I personally think the that rapid reduction in shedding that most have reported (myself included) is a testament to the anti-DHT effect of s-equol or a combo of other components of brotzu formula. What is occurring, at least to me, is now a return to the same levels of shedding I had before...

All drugs are metabolized primarily by liver because if they are taken orally they must first pass the liver (where they can be metabolized to their active form or catabolized (broken down) to an inactive molecule or released intact into the into systemic circulation. Topicals would directly...

University PhD pharmacologist here. Just some thoughts on the anecdotes of sexual sides posted in this forum. There will always be systemic absorption of topicals that can penetrate the skin, albeit much lower than oral/systemic drugs. For example topical diclofenac sodium goes systemic at...

Thanks!

Hi Godsend, Thanks for the post. I am new to dermaroll. Can I ask why do you wait 12 hours before applying the Trinov? I thought it is best to dermaroll and then to apply topicals right after? Is it because of risk of systemic absorption? Do you dermaroll every day and what is the length? I...