Re: A recently discovered new factor in AA, the cure is near :)
yes :thumbdown2: i don't use minoxidil because I used for 5 months some years ago and I got some wrinkles in my forehead and worst dark eye circles... Now I use finasteride 1mg once a day and kotoconazole shampoo 2% 3 times a week...
Re: A recently discovered new factor in AA, the cure is near :)
First, "PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness" .. so I think something is causing an excess of PTGDS (PTGDS is PGD2 Synthase, so, the stuff that converts PGH2 to PGD2)...
Re: A recently discovered new factor in AA, the cure is near :)
I think we must investigate this with scientific method... think in a hypothesis, and try to refute it or prove it.. and then go on...
I'll start with:
1. PGD2 needs DHT to cause hair loss.
2. PGD2 without DHT doesn't cause hair...
Re: A recently discovered new factor in AA, the cure is near :)
year 0 : scalp = pgd2 + dht + low pge2 => hair loss
year 1: scalp + finasteride = pgd2 + low pge2 => stops hair loss
year 2: scalp + finasteride + minoxidil = pgd2 + normal pge2 => previous hair +new hair
year 3: scalp +...
Re: A recently discovered new factor in AA, the cure is near :)
I was thinking.. DHT cant cause the increase in PGD2 production... let me explain..
finasteride inhibits DHT production...
if someone uses finasteride for a year for example... and stops hair loss
then use finasteride and...
Re: A recently discovered new factor in AA, the cure is near :)
1st , sorry for my poor english :)
perhaps male pattern baldness follicles are different in some way, and vulnerable to DHT, and when they are "atacked" by DHT , in response the skin produces PGD2 , and this prostaglandin makes the follicle to...
Re: A recently discovered new factor in AA, the cure is near :)
I wanted to recommend you a usefull website for chemistry calculations and also for genes , weather, etc.. perhaps you will need it for knowing the dosage of cetirizine you are using or for other calculations... :)...
Hi! First, sorry for my poor english :whistle:
I wanted to ask you if anyone is trying any TOPICAL experimental treatment like any of the next ones... :)
* CRTH2 (or GPR44) Antagonists: Indole-3-acetic acids,Ramatroban and analogues, 4-aminotetrahydroquinoline derivatives K117 and K604.
*...