S5 Plus Cream – Tempol Content Reduced for Stability

by HairLossTalk | May 12, 2017 3:11 pm

Just a quick note to all current (and future?) S5 Plus Cream[1] users.  Up until this point we’d published that the contents of S5 Plus Cream were as follows:

Spironolactone 5%
Alfatradiol 0.05%
Tempol 3.5%

This is in fact how the solution was created, but after some time, it became apparent that in order to maintain the solution in its glorious, lustrous, absolutely perfect texture (which they worked for weeks trying to perfect), the amount of Tempol needed to be reduced to 0.8% (basically 1%).  In fact, even when 3.5% Tempol is introduced to the solution, it degrades itself to about 0.8% due to the preparation methods.

I confirmed with resident bio-chem expert “Swoop” (aka Swooping) as to whether 1% versus 3.5% would have any significant effect on people’s hair status, and it was an unequivocal and clear “no”.  Not a lot of Tempol is needed to do its job, so all is well.

Vitamin C (Ascorbic Acid)

We also discussed the protective effects ascorbic acid plays on preventing the degradation of Tempol during heating and preparation, to help stabilize it.  So there’s a possibility if they add Vitamin C to the solution, they’ll end up with a higher Tempol content after heating.

In any case, just wanted to do a little “PSA” to everyone as they continue moving forward to perfect the cream.  So now the percentages for S5 Plus Cream are:

Spironolactone 5%
Alfatradiol 0.05%
Tempol 0.8%  (basically 1%)

Read more About the S5 Cream Products

Not sure what S5 Cream is, or why its so awesome?  Here are some helpful links:

Ideas or Suggestions?

If you have any requests, ideas, or suggestions for topical compounds that might have benefits for hair loss, please post your comments in the comments area below.  I’ve heard a lot of ideas bandied around like Minoxidil + Spiro, and some others.

Get the conversation going – and I’ll make sure to direct the manufacturer here to see if they can make some of them.

You don’t need to set up an account, and you can probably use a fake email – unless you want to get alerts about replies.

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Endnotes:
  1. S5 Plus Cream: https://www.hairlosstalk.com/treatments/s5-plus-cream/
  2. New Topical Spironolactone Treatments for Hair Loss: https://www.hairlosstalk.com/news/treatments/s5-cream-returned/
  3. Interview with Dr. Lee on merits of Topical Spironolactone: https://www.hairlosstalk.com/news/treatments/odorless-topical-spiro-lotion/
  4. S5 Cream Product Reviews: https://www.hairlosstalk.com/treatments/s5-cream/
  5. S5 Plus Cream Product Reviews: https://www.hairlosstalk.com/treatments/s5-plus-cream/
  6. The Science Behind S5 Cream: https://www.hairlosstalk.com/uncategorized/science-behind-s5-cream-topical-spironolactone/
  7. How to Apply S5 Cream to a scalp with thinning hair: https://www.hairlosstalk.com/news/treatments/how-applying-s5-cream-to-scalp/

Source URL: https://www.hairlosstalk.com/news/treatments/s5-plus-cream-tempol-content-reduced/