Neurotrophins have several non-neuronal functions in the skin. Previously we have shown that p75 kD neurotrophin receptor plays an important role during HF morphogenesis and that neurotrophins…
One of the most accepted means to identify keratinocyte stem cells takes advantage of the fact that they are normally rarely cycling in vivo, and can be detected experimentally as the…
Three double-blind, randomized, placebo-controlled studies were conducted in 1879 men ages 18 to 41 years with mild to moderate hair loss. Two of the studies enrolled men with…
Epithelial-mesenchymal interactions govern the initiation of organ development, subsequent morphogenesis and terminal cytodifferentiation. The developing tooth of the mouse is a good model for…
It is well known that sex hormones such as androgen and estrogen influence the hair growth in several animals. Aromatase is a member of cytochrome P-450 gene superfamily and…
Nitric oxide (NO) has been identified as an important mediator in various physiological and pathophysiological processes of the skin, such as regulation of blood flow, melanogenesis…
Although potassium channel openers such as minoxidil promote hair growth in vivo, the mechanisms by which they do so are unclear. Using a red deer whole hair follicle culture system we…
Signal transducer and activator of transcription 3 (Stat3) is involved in many signaling pathways for growth factors and cytokines. Its deficiency in mice therefore…
While the significance of androgens as major modulators of hair growth is well-established, much less is known on the exact follicular functions of other nuclear hormone receptor…
Androgenetic alopecia (AGA) is caused by androgens in genetically susceptible women and men. The thinning, also known in women as female pattern hair loss, begins between…
