Sir_LagaLot
Established Member
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hey guys, got this off some forum at hairhelper.net . i know the same topics are repeated over'n over but what do you make of this. not so many people on these forums have tried zix i think. socks and a few other guys. some say it works, others call it crap. anybody get any results from ZIX ?
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"Abstract of Stamatiadis' 1988 study:
Br J Dermatol 1988 Nov;119(5):627-632 Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.
Stamatiadis D, Bulteau-Portois MC, Mowszowicz I
Laboratoire de Biochimie B, Hopital Necker-Enfants-Malades, Paris, France.
The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.
PMID: 3207614, UI: 89087983
The reservations one might have regarding the Stamatiadis study are (1) that the study was done on rats, (2) that is was done on prostate tissue (and not on hair tissue) and (3) that it was done "in vitro" (essentially means, "not in a living organism"). Cells in living tissue generally show a considerable ability to protect themselves from invasion. Treating pure 5-AR directly with azelaic acid in a lab flask is somewhat different from exposing the living cell to azelaic acid. Nevertheless, what happens "in vitro" often reveals clues as to what might happen "in vivo" (in a living organism)."
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"Abstract of Stamatiadis' 1988 study:
Br J Dermatol 1988 Nov;119(5):627-632 Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.
Stamatiadis D, Bulteau-Portois MC, Mowszowicz I
Laboratoire de Biochimie B, Hopital Necker-Enfants-Malades, Paris, France.
The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.
PMID: 3207614, UI: 89087983
The reservations one might have regarding the Stamatiadis study are (1) that the study was done on rats, (2) that is was done on prostate tissue (and not on hair tissue) and (3) that it was done "in vitro" (essentially means, "not in a living organism"). Cells in living tissue generally show a considerable ability to protect themselves from invasion. Treating pure 5-AR directly with azelaic acid in a lab flask is somewhat different from exposing the living cell to azelaic acid. Nevertheless, what happens "in vitro" often reveals clues as to what might happen "in vivo" (in a living organism)."
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