Wholllly Shiaat This Gyno On Bicalutamide, Help!!!

BadInvertor

Banned
My Regimen
Reaction score
108
Broken record.

Broken tranny, broken dick, broken body and broken brain lmao, you guys have all the qualities.. Now shh my date is almost here sorry to leave you guys so early but see you tomorrow.. Don't forget to take your tranny drugs kids and play nice with the other incels see you later !
 

DoctorHouse

Senior Member
Reaction score
5,695
Broken tranny, broken dick, broken body and broken brain lmao, you guys have all the qualities.. Now shh my date is almost here sorry to leave you guys so early but see you tomorrow.. Don't forget to take your tranny drugs kids and play nice with the other incels see you later !
I thought Jason killed Freddy Kruger. Yet, he keeps coming back haunting these poor young guys in their nightmares. This is worse than A Nightmare On Elm Street. 1,2, Freddy's coming for you, 3,4 lock your door, 5,6 Grab your crucifix, 7,8 time to stop this hate............................
 

Ikarus

Banned
My Regimen
Reaction score
2,891
But please tell us @Ikarus you said that your doctors are getting documented on Bica, how did it go, will they prescribe it to you or you have to cry and threaten them with suicide to get it ?

My doctors are great, and prescribed me spironolactone in the past. They had no idea bicalutamide existed, and they have to do research about it otherwise they can get in legal trouble. Dermatologists and endocrinologists don’t normally prescribe it, it’s generally prescribed by gender specialists and oncologists.
 

Ikarus

Banned
My Regimen
Reaction score
2,891
Get the f*** out, they insulted me also from the start and just the fact that they are promoting anti cancer pills to 16 years olds is enough to insult them.. Most of them are mentally ill BDD kids who are not even balding in the first place.. And here you come out of nowhere, after reading 10 comments and having no idea about the whole situation and bringing your shitty opinion that nobody cares about.. And regarding my behavior i only f*** trannies with my big working dick if they want, and i can arrange you also if you want !
And if it bothers you so much you could take the advise you are giving others and block who you don't like also if you don't want to see somebody's comments ! So f*** off mister lawyer and mind your own business nobody asked you nothing anyways, i think you were triggered because mostly you are an incel or a tranny also so it's understandable !

Now i saw it was clearly why you got triggered, you came from the tranny hormonal thread lmao, another triggered tranny incel !

CC91DA52-5837-4B6E-B935-6C4B679787BE.jpeg
 

itsyaboi

Established Member
My Regimen
Reaction score
191
TLDR but badincel didn’t you say you blocked everyone on this thread in another post? Seems like you just can’t get enough of this thread but you do you; whatever keeps you off the meth I guess???
 

BadInvertor

Banned
My Regimen
Reaction score
108
TLDR but badincel didn’t you say you blocked everyone on this thread in another post? Seems like you just can’t get enough of this thread but you do you; whatever keeps you off the meth I guess???

Lmao, go back to your basement incel nobody asked you anything
 

baba_yaga

Experienced Member
My Regimen
Reaction score
644
Lmao, your not even balding you incel what disease are you talking about lol
You only hear what you want to hear. I told you I visited two derms, and both confirmed diffuse thinning and very minor left temple thinning. Also I sent an image with miniaturized hair clearly showing.
You really should find a life.
 

BadInvertor

Banned
My Regimen
Reaction score
108
You only hear what you want to hear. I told you I visited two derms, and both confirmed diffuse thinning and very minor left temple thinning. Also I sent an image with miniaturized hair clearly showing.
You really should find a life.

Incels telling others to find a life, hilarious lmao
 

baba_yaga

Experienced Member
My Regimen
Reaction score
644
hows ur minoxidil journey? harsh initial shed? any regrowth? any sides?
Minor shed at 3rd week. Went on for about a week. Since then nothing special. Its been I guess 4 months, my hair still looks/feels the same as before, no regrowth. Only positive outcome is I shed much much less from the top (where I put minoxidil) compared to the back. (I have zero hair loss on the back though)
No side effects at all.
 

DHTcel

Banned
My Regimen
Reaction score
2,935
UPDATE: decided to reduce my raloxifene dose back down to 60mg from 90mg.

If you do research on raloxifene, tamoxifen. They are basically bicalutamide but for estrogen.

Raloxifene/tamoxifen bind to the estrogen receptor in the same ligand binding site as estradiol, but causes the estrogen receptor to fold in such a way that prevents coactivators from forming a complex with the estrogen receptor. And as a result, estrogen-responsive genes that depend on the presence of the coactivator are not expressed. Additionally, raloxifene promotes the recruitment of corepressors to the ER.

This only happens on tissues that rely on ERα expression such as hair follicles and breast tissue.

So mathematically speaking, Raloxifene/Tamoxifen definitely have a negative impact on hair. BUT this is dependent on the dose of the drug. AND even a low dose of the drug can CAUSE damage to hair follicles since low doses can cause upregulation of HPG-axis via increases in testosterone

To confirm this I bring up PSA again.

"Raloxifene significantly increased serum concentrations of LH and FSH (by 29% and 21%), total testosterone (20%), free testosterone (16%) and bioavailable testosterone (not bound to sex hormone-binding globulin (SHBG; 20%). In parallel with testosterone, 17 beta-oestradiol also increased by 21%. SHBG increased by 7%. ... Total PSA increased by 17% without significant changes in free PSA or free/total PSA ratio."

Tamoxifen increases PSA by around 50% though so its a lot worse for hair follicles.

This is similar to the increase in total testosterone from Raloxifene (20%) and Tamoxifen (50%) (increase in testosterone is regardless of dose)

CONCLUSION: I will stay on the 60mg dose until I get my PSA and testosterone level tested to see where my hormonal profile lies in late September, thank you all.
 

justbeconfident

Established Member
My Regimen
Reaction score
80
Minor shed at 3rd week. Went on for about a week. Since then nothing special. Its been I guess 4 months, my hair still looks/feels the same as before, no regrowth. Only positive outcome is I shed much much less from the top (where I put minoxidil) compared to the back. (I have zero hair loss on the back though)
No side effects at all.
how do u apply minoxidil to scalp? in my experience its very hard to get any product to get to your skin through mid or longer length hair, it just gets stuck in the hair, makes it greasy and very little gets to actual skin
Do you have any specific technique how you apply it? What brand you are using now? Foam/liquid? It doesnt get on your face after you sleep and your hair touches pillow where you face lies?
Sorry for too many questions. Im planning to give a minoxidil a sh*t, since finasteride didnt work for me, so trying to understand how to approach it
 

baba_yaga

Experienced Member
My Regimen
Reaction score
644
how do u apply minoxidil to scalp? in my experience its very hard to get any product to get to your skin through mid or longer length hair, it just gets stuck in the hair, makes it greasy and very little gets to actual skin
Do you have any specific technique how you apply it? What brand you are using now? Foam/liquid? It doesnt get on your face after you sleep and your hair touches pillow where you face lies?
Sorry for too many questions. Im planning to give a minoxidil a sh*t, since finasteride didnt work for me, so trying to understand how to approach it
I have long hair. I part my hair and put minoxidil in the exposed skin. I part my head several times, and each part is a little away from the preceding one. This way my whole head is covered.
Yes my hair gets greasy while rubbing minoxidil a little bit. I use liquid minoxidil, named Alopexy. No it does not get on my pillow, I put it 10 minutes before bed. It dries in an hour.

How did finasteride not work? What was your experience with it?
 

Jacob Williams

Established Member
My Regimen
Reaction score
78
Do you think raloxifene at 60mg has hindered your regrowth at all? I ended up buying an 80 day supply of raloxifene even though I said I was just gonna let my boobs grow then get surgery. I’m still anxiously waiting for my drugs to arrive, do you think it would be better to stagger when I start taking each? I’ve heard antiandrogens take time to take effect, I wouldn’t want raloxifene to go ham on my hairline before bicalutamide has a chance to catchup.


UPDATE: decided to reduce my raloxifene dose back down to 60mg from 90mg.

If you do research on raloxifene, tamoxifen. They are basically bicalutamide but for estrogen.

Raloxifene/tamoxifen bind to the estrogen receptor in the same ligand binding site as estradiol, but causes the estrogen receptor to fold in such a way that prevents coactivators from forming a complex with the estrogen receptor. And as a result, estrogen-responsive genes that depend on the presence of the coactivator are not expressed. Additionally, raloxifene promotes the recruitment of corepressors to the ER.

This only happens on tissues that rely on ERα expression such as hair follicles and breast tissue.

So mathematically speaking, Raloxifene/Tamoxifen definitely have a negative impact on hair. BUT this is dependent on the dose of the drug. AND even a low dose of the drug can CAUSE damage to hair follicles since low doses can cause upregulation of HPG-axis via increases in testosterone

To confirm this I bring up PSA again.

"Raloxifene significantly increased serum concentrations of LH and FSH (by 29% and 21%), total testosterone (20%), free testosterone (16%) and bioavailable testosterone (not bound to sex hormone-binding globulin (SHBG; 20%). In parallel with testosterone, 17 beta-oestradiol also increased by 21%. SHBG increased by 7%. ... Total PSA increased by 17% without significant changes in free PSA or free/total PSA ratio."

Tamoxifen increases PSA by around 50% though so its a lot worse for hair follicles.

This is similar to the increase in total testosterone from Raloxifene (20%) and Tamoxifen (50%) (increase in testosterone is regardless of dose)

CONCLUSION: I will stay on the 60mg dose until I get my PSA and testosterone level tested to see where my hormonal profile lies in late September, thank you all.
,
 

DHTcel

Banned
My Regimen
Reaction score
2,935
Do you think raloxifene at 60mg has hindered your regrowth at all? I ended up buying an 80 day supply of raloxifene even though I said I was just gonna let my boobs grow then get surgery. I’m still anxiously waiting for my drugs to arrive, do you think it would be better to stagger when I start taking each? I’ve heard antiandrogens take time to take effect, I wouldn’t want raloxifene to go ham on my hairline before bicalutamide has a chance to catchup.



,
I dont think 60mg will hurt your hairline. in studies the 60mg raloxifine dose = 20mg tamoxifen didn't reduce effectiveness of bicalutamide

so im gonna stay on 60mg from now on

but I do think that higher than 60mg can really damage hair. at least in my experience
 

DHTcel

Banned
My Regimen
Reaction score
2,935
I have long hair. I part my hair and put minoxidil in the exposed skin. I part my head several times, and each part is a little away from the preceding one. This way my whole head is covered.
Yes my hair gets greasy while rubbing minoxidil a little bit. I use liquid minoxidil, named Alopexy. No it does not get on my pillow, I put it 10 minutes before bed. It dries in an hour.

How did finasteride not work? What was your experience with it?
Finasteride only reduces PSA by around 25%, its the weakest antiandrogen
 

Attachments

  • Screen Shot 2019-08-22 at 9.50.17 PM.png
    Screen Shot 2019-08-22 at 9.50.17 PM.png
    85.1 KB · Views: 201
Top