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Update From The God Himself - Dr. Takashi Tsuji
- Thread starter kingjohn
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There plenty of evidence that even the the hairs from the donor zone thinned in a matter of 2-3 years after the transplant . A time period that way faster to thinned rather then if it would never been extract from donor zone.
That's probably because they are being taken from areas where the person was already prone to miniaturization (ie the NW5-6 zone) and then get blasted by scalp DHT plus shock damage on move. Even with FUT, I see strip scars in the NW6 zone on the sides all the time.
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Hang around the transplant world for long enough and you hear plenty of those reports. Transplanted hairs thinning and donor area thinning. It's not a consistent thing but it definitely happens. Severe baldness takes no prisoners. The "safe zone" is not 100% safe, it's just being hurt less severely.
Some guys even report their transplanted hairs thinning faster than the rest of the donor hair it came from. It's not unheard-of.
The guys who got early plug grafts (like 4mm chunks) used to report a "donuting" problem where the center of the grafts would bald out compared to the perimeter. I don't think that has ever been explained very well. Just catch-all explanations like "reduced circulation due to scarring". IMO the phenomenon seemed too specific for that to cover it.
Some guys even report their transplanted hairs thinning faster than the rest of the donor hair it came from. It's not unheard-of.
The guys who got early plug grafts (like 4mm chunks) used to report a "donuting" problem where the center of the grafts would bald out compared to the perimeter. I don't think that has ever been explained very well. Just catch-all explanations like "reduced circulation due to scarring". IMO the phenomenon seemed too specific for that to cover it.
Nope im taking about the safe one the real donor zone.
Then they have dupa/retrograde or another type of hair loss that extends to the new follicles like a scarring alopecia that was never treated. This isn't a one size fits all.
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I did my part by donating to riken.
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You are like a breath of fresh air
Dr. Tsuji is planning to put hair regeneration in clinical practise around 2026.
This is his last interview done 2 weeks ago for japanese newspaper:
globe.asahi.com
Like I understand he is creating new management team (probably new company) and they will looking for investments to start clinical trials.
This is his last interview done 2 weeks ago for japanese newspaper:
再生医療技術を活用、理研チームの「髪のタネ」量産計画は悩み解消の決定打になるか：朝日新聞GLOBE＋
古今東西、多くの人々が年齢とともに減っていく髪の毛に心を痛めてきました。かつらは借り物だし、最近はやりの自家植毛もいわば「髪の毛の引っ越し」なので、髪の総本数は増えません。いっそ「髪のタネ」の大量生産で、髪不足の一気解決を狙おう―ー。...
Like I understand he is creating new management team (probably new company) and they will looking for investments to start clinical trials.
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from the article:
I think people went totally retarded on this forum about tsuji and pointing him as this villain who is a fraud trying to deceive people when in reality he is reputable researcher at one of the top institutes in the world and foremost a scientist and not a business man. people always go become super weird here attacking researchers, finding out their phone numbers and calling them actually expecting a reply(who would lets be real do that in any other setting?) same with stemson. additionally, he is working on other aspects of regenerative medicine on the side of this like tooth regeneration and skins/other organs etc if you look at his publishing record.
furthermore, he is absolutely right about the fact that it is difficult to receive so much funding for a condition that is not life threatening. 2020 was the year covid hit so his explanation for why things went down and not according to plan makes sense and is justifiable.
I mean it says it right there, they actually went the way and applied for trials and organ technologies failed them and it was hard to burden. I hope they can get the funding, still think tsujis approach is easier to implement then stemson with current technological possibilities and especially easier to role out for mass production as long as IPSC mass manufacturing has not been figured out
I think people went totally retarded on this forum about tsuji and pointing him as this villain who is a fraud trying to deceive people when in reality he is reputable researcher at one of the top institutes in the world and foremost a scientist and not a business man. people always go become super weird here attacking researchers, finding out their phone numbers and calling them actually expecting a reply(who would lets be real do that in any other setting?) same with stemson. additionally, he is working on other aspects of regenerative medicine on the side of this like tooth regeneration and skins/other organs etc if you look at his publishing record.
furthermore, he is absolutely right about the fact that it is difficult to receive so much funding for a condition that is not life threatening. 2020 was the year covid hit so his explanation for why things went down and not according to plan makes sense and is justifiable.
I mean it says it right there, they actually went the way and applied for trials and organ technologies failed them and it was hard to burden. I hope they can get the funding, still think tsujis approach is easier to implement then stemson with current technological possibilities and especially easier to role out for mass production as long as IPSC mass manufacturing has not been figured out
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About the same time as Follica will come out.
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hair is more compexe than them ...., before hair regeneration we'll know how regenerate most others human organs, and Tsuji know it.
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wow you are so smart, I forgot this forum only hosts the really big brains
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Brotz-uji
The next milestones in generating artificial organs
www.riken.jp
The organoid project
We’re entering an era where developmental biologists alone can’t solve forthcoming organoid challenges. The Organoid Project is a consortium that brings together RIKEN researchers and external collaborators to tackle organoid challenges and find real-world applications. In addition to developmental biologists, the Organoid Project includes researchers and technicians with expertise in areas such as microdevices, 3D printing, biomaterials and bioinformatics. This positions us uniquely to become a world-class base for generating organs in 3D.Research under the Organoid Project spans the four key phases that take us from basic research to real-world applications: research on the self-organization mechanisms in stem cells; designing organoids; long-term culture and maturation; and optimization for applications.
Developmental biologist Mitsuru Morimoto and I work on the earlier phases of this process at RIKEN’s Kobe campus. Here, Morimoto’s team has succeeded in developing human lung alveoli organoids in the lab, which are now being used to model and develop treatments for lung diseases, such as pulmonary fibrosis, a scarring of the lungs.
His team has also elucidated the cell–cell communication signaling in the foregut, the top end of the esophagus, the stomach, and a portion of the duodenum, which is the embryonic origin of the trachea and esophagus. They have used these findings to develop tracheal cartilage tissue from human pluripotent cells. His group is now collaborating with the Center for Stem Cell and Organoid Medicine (CuSTOM) at Cincinnati Children’s Hospital Medical Center in the United States to create a multiple organoid system that replicates the respiratory organs and esophagus.
Meanwhile, my team has established a method for generating kidney and bladder organoids from human induced pluripotent (iPS) cells. The kidney organoids have all the components of a nephron, the functional unit of the kidney. The bladder organoids exhibit a barrier function that holds urine in a way similar to the bladder, and we have also been able to replicate the muscle layers surrounding the bladder, which help hold and release urine.
However, a new frontier for organ regeneration is to replicate entire organ systems instead of standalone organs. From a surgical point of view, transplanting a whole urinary tract system instead of a kidney organoid alone could increase the likelihood of a transplant being successful. My team is working to connect organoids of the kidney, bladder and ureter, which connect the kidneys to the urinary bladder, to replicate the urinary system.
A challenge is that the urinary system connects organs, tissues and cells derived from two of three types of cell layers, called germ layers, formed in the third week of human embryonic development. The relevant cells here are from the endoderm—which develop into the inner linings of the body, such as the digestive system and bladder—and from the mesoderm, which develop into the kidney, muscles, and red and white blood cells, among other things. The connections at the kidneys and bladder are a rare point where these two types of tissues connect, and replicating this connection would be a major feat.
Research by Takashi Tsuji of RIKEN BDR and Masayo Takahashi—formerly at RIKEN and now an external collaborator at Kobe City Eye Hospital—is closer to real-world applications. Tsuji’s team has developed a groundbreaking method, called the organ germ method, which uses organ-inducing epithelial and mesenchymal stem cells to replicate organogenesis, which is the growth and differentiation of tissues into organs during embryo development. In mice, his team has succeeded using this method to regenerate fully functional teeth, hair follicles and the salivary and lacrimal glands.
Using pluripotent stem cells, Tsuji’s team has also generated organoids of the pituitary gland, salivary gland and 3D integumentary system, a skin system that includes hair follicles and sebaceous glands. He is now focusing on bringing the functional regeneration of teeth and hair follicles to world-first human clinical trials.
2023 RIKEN BDR-CuSTOM Joint Organoid Symposium
2023 RIKEN BDR-CuSTOM Joint Organoid Symposium“Integrated organoid science: Stem Cells, Engineering, Medicine” will be held at RIKEN Center for Biosystems Dynamics Research in Kobe, Japan on February 15 to 17, 2023.
www2.bdr.riken.jp
Organizer: Mitsuru Morimoto, Minoru Takasato, Takashi Tsuji (RIKEN BDR, Japan)
Takanori Takebe, James M. Wells, Aaron M. Zorn (CuSTOM, Cincinnati Children's Hospital Medical Center, USA)
Great news from Dr. Takashi Tsuji!
The name of the new company and new website:
The new company will get investments and funding from Kobayashi Ltd:
www.kobayashi.co.jp
The name of the new company and new website:
The new company will get investments and funding from Kobayashi Ltd:
毛髪と歯の再生事業を推進するオーガンテック社へ出資 ～再生医療分野の拡大を支援～ | ニュースリリース | 小林製薬株式会社
毛髪と歯の再生事業を推進するオーガンテック社へ出資～再生医療分野の拡大を支援～小林製薬株式会社（本社：大阪市、社長：小林章浩、以下「当社」）は、毛髪と歯の再生事業を推進するバイオベンチャー企業 株式会社オーガンテック（旧社名：株式会社オーガ...
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They happily receive money to do “research” until the day they die. He’s not actually ever going to launch anything…. Right guys?Great news from Dr. Takashi Tsuji!
The name of the new company and new website:
The new company will get investments and funding from Kobayashi Ltd:
毛髪と歯の再生事業を推進するオーガンテック社へ出資 ～再生医療分野の拡大を支援～ | ニュースリリース | 小林製薬株式会社
毛髪と歯の再生事業を推進するオーガンテック社へ出資～再生医療分野の拡大を支援～小林製薬株式会社（本社：大阪市、社長：小林章浩、以下「当社」）は、毛髪と歯の再生事業を推進するバイオベンチャー企業 株式会社オーガンテック（旧社名：株式会社オーガ...
- Reaction score
- 179
yes bwtter start without the preclinical studies and then fail in clinical studies to delay another decade and waste a few millions. great