Topical Dutasteride Case Assessment Thread

Mustang

Experienced Member
My Regimen
Reaction score
378
I am not trying to refute a study. I am trying to see what happens with my serum DHT using this dosage and at even lower frequency.

If my DHT plummets or decreases 50-70% with this dosage twice a week it's pretty obvious this treatment is not for me.

If anything my experiment is beneficial as this drug is accumulative and one week doesn't say much.

We will see. I'll do bloodwork baseline, one week, one month and maybe increase to 1ml daily to then to repeat a week later. Let's see what happens.

Why is this a problem for you? So much negativity on this thread. You rather me not test anything and not report anything?
 

corkmeister

Established Member
Reaction score
189
I am trying Topical Finasteride 0.025% twice a week because I want to confirm or refute the research that it only reduces 25% of serum DHT
The only research that shows this is the Caserini study
I am not trying to refute a study.

It's not a problem for me, I welcome any data you might provide but I'm just trying to make sense of what you're trying to do here. You're just extremely hard to follow which makes people skeptical and wary of any data that you do report.

All I'm saying is that this experiment cannot confirm or refute the findings of another experiment which was set up completely differently. But you don't seem to disagree with that, so maybe that was just a miscommunication. I guess you meant that in the broadest sense, the Caserini studies show that topical finasteride is theoretically viable in terms of serum inhibition vs efficacy? And that's what you want to test out? Whatever the case, I agree that it'll be interesting to see what the effects of .025% twice a week will be. I've always believed that the key to using topical finasteride succesfully is building up the effect very slowly over time until you reach an equilibrium, whereas the approach in the Polichem studies was too fast (i.e. too high a dose) because after a week you're already at the point where the body can no longer keep up with the amount of finasteride going into circulation.
 
Last edited:

Mustang

Experienced Member
My Regimen
Reaction score
378
Yes, you got it right. I don't see how me posting my bloodwork (good or bad) would be beneficial for me on a compound available everywhere.

I hate Finasteride. I am giving it a last try to see what happens at such a low dosage. Perhaps it is true that lowering the dose helps.

I am trying to find out if this is a viable option for me and what kind of build up 0.025% presents in the body after 2 months
 

Btg

Experienced Member
My Regimen
Reaction score
535
caserini study was bullshit, phase 3 trials proved that p3074 was the same as taking oral finasteride in the long term
 

corkmeister

Established Member
Reaction score
189
caserini study was bullshit, phase 3 trials proved that p3074 was the same as taking oral finasteride in the long term

How was it bullshit? It all depends on the conclusion you draw from it. I think it's pretty significant that it's possible to achieve a 50% reduction in scalp dht paired with a 25% reduction in serum dht. It's just that arriving at that point after only a week is not desirable, as it'll obviously continue to drop further after that. But the fact that such a ratio is possible is interesting in itself.

The marketing pitch that topical finasteride only reduces 25% serum dht is obviously nonsense, but the results of the study open some interesting possibilities. They should have done follow-up studies at lower dosages for longer periods of time.
 

Mustang

Experienced Member
My Regimen
Reaction score
378
I am offering myself to find out

I'll dose it twice a week for a month (test baseline, 1 week and at 1 month). If it remains stable and the same after one month at least we know that 0.025% could potential only inhibit 25% after 5 weeks of usage dosed twice a week. Finasteride acts during 4 days despite the short half life. Given the drug's half-life I doubt much more accumulation would occur.

Then I'll do it daily for another month and check again and back to twice a week to check for a last time.

I have no no further systemic accumulation with Topical Dutasteride at 0.1% once the cycle has been met. In fact may last DHT test came out above 300 and it was 270 before with 0.1%. It got has low as 175 with 0.5% but I mega dosed purposely to see.

I am done with Parati. I ran out of Trichosol and bought a few bottles. Got them. Insomnia, no libido, dead dick, no morning wood (it's 3am now and just woke up again after 4 hours) and anxiety after 2 applications of 0.5%. So much for Liposomes preventing systemic absorption. At least there is no brain fog. Also, it's a complete pain in the *** to apply this gel if you have long hair. It leaves it sticky for hours.

Back to 0.1% Trichosol after this. Open to try 0.25% as well.
 

Stating facts

Established Member
My Regimen
Reaction score
78
Everyone, did any of you had an unexplained morning wood on topical dutasteride? With unexplained I mean that it was so unusual that it hurts in the boxers. Sorry for the weird anecdote, but I am not using anything apart from topical dutasteride after stopping minoxidil due to its ineffectiveness on my hair. Thus I attribute this to topical dutasteride.
Yes I know that T increases on dutasteride, but with my application of 1mg every 10 days, and this too happening on 5th day after the last application was surprising.
 

Paul C

New Member
My Regimen
Reaction score
3
Well, the shed has reduced after around 3-4 months, but no new regrowth so far.
I'm just about to start topcial dutasteride and nervous about shed. What happens? Do you initially look more bald then recover?

Where are you at right now? Are you more, less or same baldness as you started with?
 

Seuxin

Experienced Member
Reaction score
323
I am offering myself to find out

I'll dose it twice a week for a month (test baseline, 1 week and at 1 month). If it remains stable and the same after one month at least we know that 0.025% could potential only inhibit 25% after 5 weeks of usage dosed twice a week. Finasteride acts during 4 days despite the short half life. Given the drug's half-life I doubt much more accumulation would occur.

Then I'll do it daily for another month and check again and back to twice a week to check for a last time.

I have no no further systemic accumulation with Topical Dutasteride at 0.1% once the cycle has been met. In fact may last DHT test came out above 300 and it was 270 before with 0.1%. It got has low as 175 with 0.5% but I mega dosed purposely to see.

I am done with Parati. I ran out of Trichosol and bought a few bottles. Got them. Insomnia, no libido, dead dick, no morning wood (it's 3am now and just woke up again after 4 hours) and anxiety after 2 applications of 0.5%. So much for Liposomes preventing systemic absorption. At least there is no brain fog. Also, it's a complete pain in the *** to apply this gel if you have long hair. It leaves it sticky for hours.

Back to 0.1% Trichosol after this. Open to try 0.25% as well.
Thanks for the feedback. My pharma grade raw dutasteride is on shipment ( i got it by a pharmacist friend...not a website), i will do my own with eth+poly80+pg+cyclodextrin, using a magnetic stirrer. Now, i wonder what dose to use...0,1% once a week ? More ? Less ? For information i'm on avodart oral since 2016, no real side, just e2 too much higher now, that's why i want to switch to topical.
 

Mr.Shelby

New Member
My Regimen
Reaction score
8
I'm just about to start topcial dutasteride and nervous about shed. What happens? Do you initially look more bald then recover?

Where are you at right now? Are you more, less or same baldness as you started with?
I am on the 6th month with topical dutasteride 0.1% with trichosol once weekly and my frontline is worse than at the beginning.

Shedding continues, thinking of coming back to oral finasteride.
 

inmyhead

Senior Member
Reaction score
954
I am on the 6th month with topical dutasteride 0.1% with trichosol once weekly and my frontline is worse than at the beginning.

Shedding continues, thinking of coming back to oral finasteride.
did you drop oral finasteride? thats scary
 

sparta03

Member
My Regimen
Reaction score
16
I am on the 6th month with topical dutasteride 0.1% with trichosol once weekly and my frontline is worse than at the beginning.

Shedding continues, thinking of coming back to oral finasteride.
what's you're % and how much ml are you putting weekly. What about of the quality of you're hair after 6 month and your itching all ?
 

losingbattle88

Established Member
My Regimen
Reaction score
115
I am on the 6th month with topical dutasteride 0.1% with trichosol once weekly and my frontline is worse than at the beginning.

Shedding continues, thinking of coming back to oral finasteride.
im on oral and topical dutasteride the shedding is quite alot still or normal like I always had but not reduced since starting which is very weird since my DHT is super low. but I wouldnt say my hair is worse and my itch is far far far less now or even gone completely. I think my hair feels slightly thicker after 5 months or unchanged. my plan is to use only oral dutasteride at 2mg daily instead of 0.5mg EOD like I did which is too weak.
 
Last edited:

losingbattle88

Established Member
My Regimen
Reaction score
115
I am offering myself to find out

I'll dose it twice a week for a month (test baseline, 1 week and at 1 month). If it remains stable and the same after one month at least we know that 0.025% could potential only inhibit 25% after 5 weeks of usage dosed twice a week. Finasteride acts during 4 days despite the short half life. Given the drug's half-life I doubt much more accumulation would occur.

Then I'll do it daily for another month and check again and back to twice a week to check for a last time.

I have no no further systemic accumulation with Topical Dutasteride at 0.1% once the cycle has been met. In fact may last DHT test came out above 300 and it was 270 before with 0.1%. It got has low as 175 with 0.5% but I mega dosed purposely to see.

I am done with Parati. I ran out of Trichosol and bought a few bottles. Got them. Insomnia, no libido, dead dick, no morning wood (it's 3am now and just woke up again after 4 hours) and anxiety after 2 applications of 0.5%. So much for Liposomes preventing systemic absorption. At least there is no brain fog. Also, it's a complete pain in the *** to apply this gel if you have long hair. It leaves it sticky for hours.

Back to 0.1% Trichosol after this. Open to try 0.25% as well.
all I get from oral dutasteride is weaker ejaculation "not always" it doesnt bother me much. my sleep is improving also, I had bad insomnia too the first few months now its much better. the dead dick and no libido and anxiety is in your head because dutasteride even boost your T.
 
Last edited:

Mr.Shelby

New Member
My Regimen
Reaction score
8
did you drop oral finasteride? thats scary
During the last year I used oral finasteride 5mg/week with good results and minimum sides, but I dont like oral antiandrogens.

Since this year I only using topical dutasteride weekly.
 

losingbattle88

Established Member
My Regimen
Reaction score
115
3ml 0.1% once per week.

I have less hair and my scalp is fine, no itching.
why would you drop oral fina if it was working for you? did you have side effects? I think you should go back to using oral fina and drop this dutasteride. maybe the dutasteride didnt penetrate well to your hair folicles to make an affect and you were only using 3ml once a week, thats not optimal dosage I think twice or three times a week makes more sense, and you still have some serum DHT that finasteride was blocking but not dutasteride. my advice drop it now go back to oral finasteride. the less hair could be shedding and you COULD eventually see thickening. but I wouldnt risk it in your case since oral fina works for you with minimal side effects.
 
Last edited:

Stating facts

Established Member
My Regimen
Reaction score
78
I'm just about to start topcial dutasteride and nervous about shed. What happens? Do you initially look more bald then recover?

Where are you at right now? Are you more, less or same baldness as you started with?
I believe existing hairs are thickening a bit, but too soon to tell for a cosmetic difference.
Maybe pretty much same on the baldness level, however from other and my personal anecdote, be prepared for a shed.
 

losingbattle88

Established Member
My Regimen
Reaction score
115
I believe existing hairs are thickening a bit, but too soon to tell for a cosmetic difference.
Maybe pretty much same on the baldness level, however from other and my personal anecdote, be prepared for a shed.
one guy I read about shed for like 6-8 months on oral duta he shedded so much he wanted to jump out a window he said. but it all turned out good at the end for him.
 

sparta03

Member
My Regimen
Reaction score
16
3 ml weekly is decent dosage with 0,1% maybe 6 month is to soon for you or maybe it just don’t work idk
 
Top