The thing is, we cannot make our conclusion based on subjective reports of sides alone, because there is a huge nocebo factor here. As I said before, it has been recorded in studies that if you tell people about the potential finasteride sides you get a higher rate of sides than if you don't tell them.To all the users of this forum, just to be clear : topical dutasteride goes systemic to an extend, enough to bring sides effects, without a doubt.
Also, you should always remember that 0.05mg of finasteride inhib almost as much DHT as 1mg of finasteride. It's probably the same mechanism for dutasteride
So, even if a very very small quantity of the dutasteride you're applying to you scalp goes systemic, there is a high chance of important Serum DHT reduction.
Obviously, topical dutasteride is a lot safer than the oral version. But just to be clear: on the Discord there are way more people who have sides with topical dutasteride than the contrary. Way more.
In other words, you could give people a sugar pill and tell them it's finasteride and they'd get sides. This is known about drugs and placebo/nocebo in general, not just as it relates to 5ar inhibitors, of ocurse.
This means that we MUST have bloodwork with these reports when reaching our conclusion of what systemic effect this has.
Now, granted, the problem is we don't know at what DHT level sides start showing up and prolly it varies, but I think it's a reasonable speculation that if it only reduces by 20% we should be safe from sides.
Now, perhaps nocebo can affect even DHT levels, I don't know.