TechnoDerma Medicines new small molecule - TDM-105795

John Difool

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The hypocrisy here is that no one even @hmmmmmmmm would wait 5 years if they had the opportunity to use the drug in 2022. These macaque pics are impressive enough to put any doubt in everyone's mind at the exception of the unfortunate folks sporting a nw6 for the last 10 years.
 

Jakejr

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I’ve tried a number of thyroid chemicals & I might still have them, but never noticed anything. Thyroid has a correlation to hair growth. but 99.9% of us are in the normal range.
 

nick123

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TechnoDerma making progress:

"SHANGHAI – January 5, 2022 Technoderma Medicines, Inc. (“the Company”), a clinical stage biopharmaceutical company, is pleased to report that the Company has begun recruitment for its second Phase 1 clinical trial of topical TDM-105795 in patients with Androgenetic Alopecia (Androgenetic Alopecia). This follows successful completion of a single dose escalation study (NCT04913519), in which no material clinical safety issues were demonstrated based on reporting of adverse events, local skin reactions and changes from baseline in vital signs, safety labs, and ECG.

This second clinical trial is a 28-day multiple dose escalation study entitled, “A Randomized, Double-Blind, Vehicle-Controlled, Parallel Group, Multi-Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TDM-105795 in Healthy Male Subjects with Androgenetic Alopecia”. Its objectives are to evaluate topical TDM-105795 repeated dose safety and toleration and its pharmacokinetics, in order to define formulation strength(s) appropriate for a proof-of-concept Phase 2 study planned to follow."

Source:
 

hmmmmmmmm

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The hypocrisy here is that no one even @hmmmmmmmm would wait 5 years if they had the opportunity to use the drug in 2022. These macaque pics are impressive enough to put any doubt in everyone's mind at the exception of the unfortunate folks sporting a nw6 for the last 10 years.
You made up a scenario and then called people hypocrites based on guessing how they'd act in it...

very goofy and not consistent with my routine or intervention history, which are very transparent (unlike yours)

Even if I could get HMI tomorrow, I'd absolutely wait for one of:
1. observation of hair growth in humans (even anecdotal)
2. a better understood mechanism
3. some kind of expert opinion that it can work

Maybe if it costed nothing and had zero risks, I'd add it as a "why not?" intervention with no expectations...
 

nick123

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You made up a scenario and then called people hypocrites based on guessing how they'd act in it...

very goofy and not consistent with my routine or intervention history, which are very transparent (unlike yours)

Even if I could get HMI tomorrow, I'd absolutely wait for one of:
1. observation of hair growth in humans (even anecdotal)
2. a better understood mechanism
3. some kind of expert opinion that it can work

Maybe if it costed nothing and had zero risks, I'd add it as a "why not?" intervention with no expectations...

Can you guys just stop like for real...

I'm trying to keep this thread about TechnoDermas TDM-105975 and all you do is derail..
 

hmmmmmmmm

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Can you guys just stop like for real...

I'm trying to keep this thread about TechnoDermas TDM-105975 and all you do is derail..
My earlier replies were on-topic, but yes I'll do my best to go back to ignoring my 2 stalkers.

Frankly, they started it
 

trialAcc

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You made up a scenario and then called people hypocrites based on guessing how they'd act in it...

very goofy and not consistent with my routine or intervention history, which are very transparent (unlike yours)

Even if I could get HMI tomorrow, I'd absolutely wait for one of:
1. observation of hair growth in humans (even anecdotal)
2. a better understood mechanism
3. some kind of expert opinion that it can work

Maybe if it costed nothing and had zero risks, I'd add it as a "why not?" intervention with no expectations...
You derail every thread with absolute sh*t posting. Go away.
 

edh38

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Even the detailed patent does not indicate TM-105795 exact formula, does it?
 

nick123

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Even the detailed patent does not indicate TM-105795 exact formula, does it?

Could you refer to what you mean by the exact formula, if you are referring to it's molecular structure then yes it is included.
 

edh38

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Could you refer to what you mean by the exact formula, if you are referring to it's molecular structure then yes it is included.
Yes that's what I meant, perfect. I just quickly searched it by ctrl+f. Will look further for it and try to get a custom quote. And will look for the company which synthesized it for TD in the first place (in the hope it wasn't TD themselves).
 

nick123

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Yes that's what I meant, perfect. I just quickly searched it by ctrl+f. Will look further for it and try to get a custom quote. And will look for the company which synthesized it for TD in the first place (in the hope it wasn't TD themselves).
Molecular structure:

1642976111995.png
 

pegasus2

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465 Daltons is not high at all. Anything under 500 should be easily absorbed
 

nick123

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There’s a new study for some analogues of TDM.

“Results: The TDM group showed early induction of anagen. 857, 782, and 276 differentially expressed genes were identified between 3 groups. As a critical DEG in group TDM, Pclaf was positively related to the motivation of Wnt/beta-catenin and Hedgehog signaling pathways, with a high expression of Ki67 and cyclinD1.

Conclusion: TDM10842 accelerates the anagen entrance and the potential mechanism might be the activation of Wnt/beta-catenin and Hedgehog pathways. Pclaf serves as a critical molecule involved in pathway activation, and cyclinD1 is an important effector protein downstream of the pathways.”

1646301901729.png
1646301934644.png


Even though this study references TDM10842, we can also assume this is the same for TDM-105975 as this is the analogue they actually went forward with.

TDM-105975 should be classified as a “thyroxine receptor agonist” and its mechanism of action is the activation of Wnt/beta-catenin and Hedgehog pathways.

Study link: https://www.dovepress.com/thyroid-h...-in-mice-peer-reviewed-fulltext-article-CCID#

Credit: @FollicleGuardian for finding this new study
 
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Seuxin

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If it activate the Hedgehog signaling pathways, it's a good thing ! Now i wonder if this stuff couldn't give side effects because of the thyroxine receptor agonist
 

Jackshtbro

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There's currently a GB running for this. 225$ + shipping for a 8-12 month supply, DM me for a discord invite if interested. Over halfway to MOQ
 
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