Stemson is going to use minipigs in the next stage of their hair cloning research

werefckd

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so simply hair may fall out after one cycle?
Yea

Or if the dermal papilla and epithelial cells contained in the hair follicle germ (sticked together with the help of the biodegradable scaffold - aka the "lolli-up") become ordinary skin scalp cells and never interact to form an actual hair follicle onto it in the first place.
 
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werefckd

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what does stemson do differently than tsuji?
Their end product is similar

Both aim to build a follicle germ with mainly dermal papilla and epithelial cells that hopefully will become a normal and healthy hair follicle once implanted in the scalp.

Where they differ is in the strategies being used to source and multiply those cells

Those strategies can have a big impact later on on the multiplied DP and EP cells abilities' to maintain their hair generating properties throughout their lifetime
 

Pls_NW-1

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Their end product is similar

Both aim to build a follicle germ with mainly dermal papilla and epithelial cells that hopefully will become a normal and healthy hair follicle once implanted in the scalp.

Where they differ is in the strategies being used to source and multiply those cells

Those strategies can have a big impact later on on the multiplied DP and EP cells abilities' to maintain their hair generating properties throughout their lifetime
Well, I know plenty of people saying that Tsuji's hair is differently to the Stemson one, in a positive manner, + that the Tsuji one is Androgenetic Alopecia resistant, while the one by Stemson is not.

Hm
 

Pls_NW-1

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"Does this mean they try to make the follicle permanent and not susceptible to Androgenetic Alopecia!? This would match then with the Fortunis guy, making claims that it will give a natural density/hairline, that the hair will stay permanently and won't bald ever. Someone remember that phrase and can elaborate it!? "
That's just my theory after reading and re-reading much stuff the past months. Stemson's approach could achieve resistant follicles or easily as well NOT. I think I mentioned why so in the post history of this thread as well.

We need more papers, details and studies to understand it better. And a proper statement from the team if it is INDEED RESISTANT.
 

jan_miezda

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Hair doesn't turn into cancer. There is no known mechanism for that.

Watch Terskiskh's interview from Oct 2020. According to them, the worst case scenario is if the hair follicle germs don't turn into actually hair follicles (or that they turn into hair follicles but later "undifferentiate" and stop producing hairs) and become ordinary skin cells.

Again, there won't be any multiplication/cloning going on in the scalp. That part is happening in the lab only. Once you get a hair follicle germ from the factory then the multiplication/cloning part is over.
there can be the case where mutated cells arise but he spoke about them finding ways to be able to identify them. They are culturing them
In optimal conditions without uv light or other mutating factors so I think the chance is low
 

Mighty

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Eh. I don’t think that it works like that lol.

It has to be backed up if the treatment is the REAL cause or if it even had a supportive role for the cancer to occur.

Finasteride is the best example for such cases, the treatments/prodecure's side effect's and within that people's (psychosomatic) opinion, such as the PFS lol.

Yet, Finasteride is a praised medication and all over the market lol
I was saying that the investigation would take some time, even if it was just a fluke. Hair cloning is a technology that sounds and smells like conspiracy theories about cancer.
 

Pls_NW-1

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I was saying that the investigation would take some time, even if it was just a fluke. Hair cloning is a technology that sounds and smells like conspiracy theories about cancer.
Very true. Sorry, might be then heavily missinterpreting.
 

Pls_NW-1

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"Such devices cost between $25,000 and $75,000 (not including maintenance and repair)"

I found this yesterday on Google Chrome's cache (yes, I am a freak), and I think this sounds pretty realistic.

I don't actually know what they mean by 'devices', but I assume it's the scaffold.

The maintenance part lets me think of the fact that either the follicles won't be identical to the occipital one's, susceptible to androgens, or will just reach their limit in terms of cycling due to being bio-engineered.
 

trialAcc

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"Such devices cost between $25,000 and $75,000 (not including maintenance and repair)"

I found this yesterday on Google Chrome's cache (yes, I am a freak), and I think this sounds pretty realistic.

I don't actually know what they mean by 'devices', but I assume it's the scaffold.

The maintenance part lets me think of the fact that either the follicles won't be identical to the occipital one's, susceptible to androgens, or will just reach their limit in terms of cycling due to being bio-engineered.
I would assume maint/repair would be follicles that grew in poorly (wrong direction) and needed to be removed or didn't grow at all. The growth rate is not going to be 100%, similar to hair transplants and you'd probably need top ups for it.

Where did you find this in the cache? I agree though this is exactly the price range I was assuming based on their investment call.
 

pegasus2

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"Such devices cost between $25,000 and $75,000 (not including maintenance and repair)"

I found this yesterday on Google Chrome's cache (yes, I am a freak), and I think this sounds pretty realistic.

I don't actually know what they mean by 'devices', but I assume it's the scaffold.

The maintenance part lets me think of the fact that either the follicles won't be identical to the occipital one's, susceptible to androgens, or will just reach their limit in terms of cycling due to being bio-engineered.
Isn't this referring to the implantation device?
 

pegasus2

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i thought the same, so cost of new hair would be from 25k to 75k$ or it is only the cost of the device?
The device would be used for many years so the cost would be spread across thousands of patients. This would be the smallest part of the cost.
 

Pls_NW-1

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I would assume maint/repair would be follicles that grew in poorly (wrong direction) and needed to be removed or didn't grow at all. The growth rate is not going to be 100%, similar to hair transplants and you'd probably need top ups for it.

Where did you find this in the cache? I agree though this is exactly the price range I was assuming based on their investment call.
I agree on the points you made. Repair sounds plausible, not all follicles would survive in the transplant process.

As I said, I found it in Chrome's Cache. I forgot copying the link :(, but I copied that paragraph xD. The cache had content of on-going research projects, trying to solve hair loss.
 

Pls_NW-1

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Isn't this referring to the implantation device?
I honestly don't know. This was the only additional info I found in the cache next to Stemson being mentioned there... :(

Anyways, I guess so, yeah? You pay for the device to transplant you xy follicles/to fulfill the procedure. The more you want, the more you pay. Ig that was meant by 'devices".

Hasn't Stemson talked about developing a robot to transplant!? Someone mentioned that in the thread's post history...
 

Pls_NW-1

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The device would be used for many years so the cost would be spread across thousands of patients. This would be the smallest part of the cost.
Oh, I had not read your other (this one) post yet. :eek:
Yeah that's pretty much it, I guess.
 

Pls_NW-1

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"
HLC2020: How do you plan to administer the treatment? A proprietary device?

Dr. Terskikh: Initially this will be done manually by the doctors. Eventually, we are discussing the development of biomedical robotic machines that will be doing the transplantation automatically."

If robots will do the treatment, I could imagine reaching perfect density.
 

NorwoodGuardian

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I hope it won't end up being like Tsuji. So far they are alike that they plan a trial, throw out a random number as price of treatment before that. I remain prudently optimistic.
 
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