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Androgen Receptor & Noggin: Latest news
Silo's unique SILencing Oligonuceotide (SILO)formulary platform has reached patrons now internationally...
Silo is the siRNA conceptus that selectively targets mRNA species like Androgen Receptor (AR) and Transforming Growth Factor Beta-1 (TGFb-1).
Transgenic Technologies uses a de novo approach to hairloss, namely their scientific team has generated antisense-like oligonucleotide technology or short-interfering RNAs i.e. Vitravene to combat androgenetic alopecia (Androgenetic Alopecia). http://www.fda.gov/cder/foi/label/1998/20961lbl.pdf
RNA interference (RNAi) is a phenomenon in which the introduction of double-stranded RNA (dsRNA) into a diverse range of cell types causes degradation of the complementary mRNA . In the hair follicle, dsRNAs are cleaved into short 21-25 nucleotide small interfering RNAs, or siRNAs, by a ribonuclease known as Dicer . The siRNAs subsequently assemble with protein components into an RNA-induced silencing complex (RISC). An ATP-generated unwinding of the siRNA activates the RISC , which in turn binds to the complementary transcript by base pairing interactions between the siRNA antisense strand and the mRNA. The bound mRNA is cleaved and sequence specific degradation of mRNA results in gene silencing.
Noggin, this unique peptide has the ability to allow for hair growth by blocking the action of BMP4 which suppresses hair growth and differentiation. By adding Noggin to your daily maintenance SILO program, you can accelerate your hair growth potential even further.
The secreted polypeptide Nogginâ„¢ (encoded by the NOG gene) binds and inactivates members of the transforming growth factor-beta superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4; ). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, Noggin may have a principal role in creating morphogenic gradients.
Groppe et al. (2002) reported the crystal structure of the antagonist Noggin bound to BMP7 which showed that Noggin inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. The BMP binding affinity of site-specific variants of Noggin was correlated with alterations in bone formation and apoptosis in chick limb development, showing that Noggin functions by sequestering its ligand in an inactive complex. The scaffold of Noggin contains a cystine (the oxidized form of cysteine) knot topology similar to that of BMPs. All in all, Noggin plays a critical roll in intiating anagen re-entry in the hair follicle.
Transgenic Technologies LLC. is submitting an abstract to the American Association of Dermatology for critical review. Currently, we offer a support group for customers using the Silo-1 to combat hairloss.
Silo's unique SILencing Oligonuceotide (SILO)formulary platform has reached patrons now internationally...
Silo is the siRNA conceptus that selectively targets mRNA species like Androgen Receptor (AR) and Transforming Growth Factor Beta-1 (TGFb-1).
Transgenic Technologies uses a de novo approach to hairloss, namely their scientific team has generated antisense-like oligonucleotide technology or short-interfering RNAs i.e. Vitravene to combat androgenetic alopecia (Androgenetic Alopecia). http://www.fda.gov/cder/foi/label/1998/20961lbl.pdf
RNA interference (RNAi) is a phenomenon in which the introduction of double-stranded RNA (dsRNA) into a diverse range of cell types causes degradation of the complementary mRNA . In the hair follicle, dsRNAs are cleaved into short 21-25 nucleotide small interfering RNAs, or siRNAs, by a ribonuclease known as Dicer . The siRNAs subsequently assemble with protein components into an RNA-induced silencing complex (RISC). An ATP-generated unwinding of the siRNA activates the RISC , which in turn binds to the complementary transcript by base pairing interactions between the siRNA antisense strand and the mRNA. The bound mRNA is cleaved and sequence specific degradation of mRNA results in gene silencing.
Noggin, this unique peptide has the ability to allow for hair growth by blocking the action of BMP4 which suppresses hair growth and differentiation. By adding Noggin to your daily maintenance SILO program, you can accelerate your hair growth potential even further.
The secreted polypeptide Nogginâ„¢ (encoded by the NOG gene) binds and inactivates members of the transforming growth factor-beta superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4; ). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, Noggin may have a principal role in creating morphogenic gradients.
Groppe et al. (2002) reported the crystal structure of the antagonist Noggin bound to BMP7 which showed that Noggin inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. The BMP binding affinity of site-specific variants of Noggin was correlated with alterations in bone formation and apoptosis in chick limb development, showing that Noggin functions by sequestering its ligand in an inactive complex. The scaffold of Noggin contains a cystine (the oxidized form of cysteine) knot topology similar to that of BMPs. All in all, Noggin plays a critical roll in intiating anagen re-entry in the hair follicle.
Transgenic Technologies LLC. is submitting an abstract to the American Association of Dermatology for critical review. Currently, we offer a support group for customers using the Silo-1 to combat hairloss.
