Serum Paroxonase 1 level may be an Indicator and Predictor of the Severity of Androgenetic Alopecia

whatevr

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Drink up boyos!

Responsibly, though. Light drinking (1-2 shots of moderate strength alcohol) will increase your serum paroxonase by up to 395% compared to non-drinkers, enough to compensate for the discrepancy in the OP study.

Getting shitfaced (>6 drinks per day), on the other hand, will lower it even further by up to 45% compared to non-drinkers. Not good.
 

zaman

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I started on Pomegranate extract on the basis of increasing paroxonase and progesterone. Apparently it's not a simple matter whether Pomegranate is estrogenic. It reduces estradiol and acts as a SERM, and in women reduces both Estrone and Testosterone. If it were estrogenic though, I don't know why people use it for ED. I keep seeing 'hormone balancing'.

Anyway, I will also be starting Alfatradiol too soon.

I haven't been taking anything recently so will be able to report any progress or lack thereof.
 

Squeegee 2.0

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The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases​


Abstract​

Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials. A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized and Aronia melanocarpa one of the most active. Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity. However, some caveats regarding the dose, length of treatment, bioavailability, and stability of these compounds in formulations still need to be addressed. Once these issues have been resolved, these compounds could be included as nutraceuticals and functional foods capable of increasing PON1 activity, thereby helping with the long-term prevention of atherosclerosis and other chronic ailments.

Table 1​

Plant preparations found to increase serum PON1 in different experimental designs.
Extract​
Experimental Model​
Dose​
Effect​
References​
Eucommia ulmoides Oliver leaf​
Diabetic C57BL/KsJ-db/db mice​
400 mg/kg bw​
↑ 22%​
[21]​
Murraya koenigii
Streptozotocin-induced diabetic mice​
150 mg/kg​
↑ 105%​
[22]​
Grape seed extracts​
Streptozotocin-induced diabetic rats​
100 mg/kg​
↑ 86%​
[23]​
Red wine polyphenol extract​
Heterozygous Cbs-deficient mice​
100 mg/kg​
↑ 20%​
[25]​
Sambucus nigra
Apoe-deficient mice​
200 mg/kg​
↑ 20%​
[26]​
Aronia melanocarpa
Apoe-deficient mice​
6 mg/kg​
↑ 39%​
[27]​
Onion extract​
Mercuric chloride-induced oxidative insult in male Wistar rats​
20 mg/kg​
↑ 30%​
[28]​
Aronia melanocarpa
Rats on a high-fructose and high-fat diet​
Not reported​
↑ 65%​
[29]​
Cornelian cherry​
Rats on a high-fructose and high-fat diets​
Not reported​
↑ 45%​
[30]​
Genistein​
Arthritic rats​
20 mg/kg​
↑ 230%​
[33]​
Euterpe oleracea Mart​
Female Fischer rats on high-cholesterol, high-fat diets​
2 mg/kg​
↑ 60%​
[34]​
Avocado​
Male Wistar rats​
28 g/kg​
↑ 33%​
[35]​
Ilex paraguariensis
Healthy volunteers​
0.5 L of extract​
↑ 10%​
[37]​
Cranberry extract with vitamin C and zinc​
Healthy volunteers​
2 g/day (300 mg/day)​
↑ 67%​
[38]​
Zingiber officinale
Type 2 diabetic patients​
3 g​
↑ 28%​
[39]​
Salvia miltiorrhiza
Type 2 diabetic patients​
Not reported​
Increased PON1 activity​
[40]​
Origanum onites
Hyperlipidemic patients​
Not reported​
↑ 14%​
[41]​
 

Squeegee 2.0

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Squeegee 2.0

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Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.​


Table 1​

Pharmaceutical drugs found to increase PON1 activity/expression in animals or Humans
Drugs​
PON1 increase​
Reference​
Cardiovascular drugs
Statins (simvastatin, atorvastatin)*​
5–23%​
[1720, 25]​
Fibrates (Gemfibrozil, fenofibrate)*​
18–59%​
[23, 29]​
Probucol​
50%​
[36]​
Ezetimibe​
32%​
[37]​
Aspirin*​
13%​
[32, 34]​
Antidiabetic drugs
Rosiglitazone​
10–67%​
[3840]​
Eplerenone​
60%​
[41]​
Sulphonylureas (glimepiride, glibenclamide)​
28–64%**​
[42]​
Other drugs
Erythropoietin beta​
23%​
[48]​

Table 2​

Dietary antioxidants found to increase PON1 activity/expression in animals or Humans
Antioxidant​
PON1 increase​
Reference​
Vitamin C, Vitamin E​
7–80%​
[5559]​
Quercetin​
30–200%​
[6266]​
Green tea​
17–40%​
[70]​
Grape seed extract​
21–87%​
[72]​
Blueberries​
25%​
[73]​
Pomegranate juice​
20–80%​
[7577]​
Dates (Hallawi variety)​
15%​
[80]​
Protandim®​
35%​
[74]​
 

Squeegee 2.0

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Squeegee 2.0

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People have taken tocopherols & tocotrienols, glutathione, NAC, astaxanthin and many other antioxidants without success.

What I love about studies like these though is that it throws a wrench in the broscience argument that balding men are the same as everyone else, but they just somehow miraculously have "DHT-sensitive folllicles". Systemic differences prove that whatever is causing Androgenetic Alopecia is present over the entire body, the hair follicle likely just manifests it the strongest.

EDIT: Apparently it's not just a mild difference either. Non balding people have 3 times as much PON1 on average.

View attachment 174751
It seems that the general consensus is a decrease of serum PON1 enzyme activities is directly associated with systematic oxidative stress and chronic inflammation. Same conclusion on every papers/studies.

example below.. I can carry on forever with so many studies.

"Genetic deletion of PON1 is associated with increased susceptibility of LDL to oxidation ex vivo, increased measures of macrophage oxidative stress, and increased lesion size in animal models of atherosclerosis; conversely, overexpression of the human PON1 transgene in mice results in reduced aortic lesion size and corresponding decreases in epitopes recognized by antibodies specific for oxidized lipid-protein adducts"
 
Last edited:

FilthyFrancis

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Anybody on high dose quercetin/genistein supplementation? Doubt it'd make a difference but shouldn't hurt
 

inmyhead

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I started on Pomegranate extract on the basis of increasing paroxonase and progesterone. Apparently it's not a simple matter whether Pomegranate is estrogenic. It reduces estradiol and acts as a SERM, and in women reduces both Estrone and Testosterone. If it were estrogenic though, I don't know why people use it for ED. I keep seeing 'hormone balancing'.

Anyway, I will also be starting Alfatradiol too soon.

I haven't been taking anything recently so will be able to report any progress or lack thereof.
are you still on it?
 

zaman

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are you still on it?

Not consistently. I lost interest a bit because I expected some sort of changes to take place in 4 months but didn't notice anything. I know that's a short time frame, but I expect to see at least something, or reduction in shedding. To be fair, I also have concerns about my liver so was recently alternating with other vitamins and having days off

Still using Alfatradiol though.
 
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