Repigmentation And New Growth Of Hairs After Anti–interleukin-17 Therapy With Secukinumab For Psoria

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A 61-year-old man with a 2-year history of plaque psoriasis treated only with topical steroids and calcipotriol was referred for a flare up of his skin disease associated with a weight loss of 10 kg. He had arterial hypertension for which he had been treated with valsartan and hydrochlorothiazide for 7 years. A histologically confirmed erythrodermic psoriasis was diagnosed, affecting 90% of his body including the scalp, with a Psoriasis Area and Severity Index (PASI) score of 41. The patient was administered secukinumab that induced complete clinical resolution at week 12 (PASI 0) with regain of the original weight. As a young man, the patient had brown hair, which began whitening by the age of 45 years. After 6 months of therapy with secukinumab, the patient, who also had androgenetic alopecia type II/III noticed that his scalp hair, which had been totally gray/white for 10 years (Fig 1, A) was becoming darker over the entire scalp with a diffuse increased hair density of approximately 15% (Fig 1, B). Trichoscopy confirmed hair repigmentation with some vellus hairs. The patient remains on secukinumab therapy with persistence of hair darkening after a follow-up of 10 months.

https://www.ncbi.nlm.nih.gov/core/l...ck on image to zoom&p=PMC3&id=6031562_gr1.jpg
Fig 1
A, After 1 month of therapy with secukinumab, the patient's hairs were still gray/white and there was a marked improvement of his erythrodermic psoriasis. B, Six months after secukinumab treatment, pronounced hair darkening of the scalp with increased hair density, total skin clearing, and regain of the original weight.



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031562/