Nitric oxide and mitochondrial biogenesis

[squeegee]

The characteristic structural organization of mitochondria is the product of synthesis of macromolecules within the mitochondria together with the import of proteins and lipids synthesized outside the organelle. Synthetic and import processes are required for mitochondrial proliferation and might also facilitate the growth of pre-existing mitochondria. Recent evidence indicates that these events are regulated in a complex way by several agonists and environmental conditions, through activation of specific signaling pathways and transcription factors. A newly discovered role of this organelle in retrograde intracellular signaling back to the nucleus has also emerged. This is likely to have far-reaching implications in development, aging, disease and environmental adaptation. Generation of nitric oxide (NO) appears to be an important player in these processes, possibly acting as a unifying molecular switch to trigger the whole mitochondrial biogenesis process. High levels of NO acutely inhibit cell respiration by binding to cytochrome c oxidase. Conversely, chronic, smaller increases in NO levels stimulate mitochondrial biogenesis in diverse cell types. NO-induced mitochondrial biogenesis seems to be linked to proliferation and differentiation of normal and tumor cells, as well as in aging.

http://jcs.biologists.org/content/119/14/2855.long

 

[Quadzilla99]

So how would this relate to products such as nitrates, agmatine, citrulline malate etc which boost NO exogenously?

 

[squeegee]

So how would this relate to products such as nitrates, agmatine, citrulline malate etc which boost NO exogenously?

This would relate to Minoxidil or any topical Nitric oxide route.

 

[Quadzilla99]

Tenks brah. I take a ton of them nitrates, agmatine, Cit Mal, before lifting. Only thing is I think its giving me a little of them raccoon eyes. Guess I'll have to try some under eye cream now, lol