- Reaction score
- 334
get ready for some tasty tachycardia and blue vision !!!
link to the study:
https://docdro.id/ky4hYTo
vehicle : Vehicle (70% polyethylene glycol + 30% ethanol), sildenafil (0.1 and 1%)
Results: We confirmed high expression of PDE5 in human dermal papilla cells (hDPCs) and human hair follicles. Sildenafil enhances proliferation of hDPCs and up-regulates the mRNA expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), which are responsible for hair growth. Additionally, sildenafil up-regulates the levels of phosphorylated ERK and accelerates anagen induction by stimulating perifollicular vessel formation after topical application in mice.
Conclusion: Our study demonstrates for the first time, the significant therapeutic potential of sildenafil on hair growth and its potential use in treatment of alopecia.
sildenafil 0.1% seems to be as good as 1%.
link to the study:
https://docdro.id/ky4hYTo
vehicle : Vehicle (70% polyethylene glycol + 30% ethanol), sildenafil (0.1 and 1%)
Results: We confirmed high expression of PDE5 in human dermal papilla cells (hDPCs) and human hair follicles. Sildenafil enhances proliferation of hDPCs and up-regulates the mRNA expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), which are responsible for hair growth. Additionally, sildenafil up-regulates the levels of phosphorylated ERK and accelerates anagen induction by stimulating perifollicular vessel formation after topical application in mice.
Conclusion: Our study demonstrates for the first time, the significant therapeutic potential of sildenafil on hair growth and its potential use in treatment of alopecia.
sildenafil 0.1% seems to be as good as 1%.