Kintor has started Phase 3 trial in China for Pyrilutamide

badnewsbearer

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You have no idea what you are talking about. The finasteride trials and not designed to actually find occurrence of sexual sides. If they were you'd see them measure how quickly it takes to achieve maximal erection with normal stimuli and how long the male is able to maintain erection without any stimulus. THAT would be scientific. Not asking the participants of the study if they experienced any sexual sides in a self report questionnaire.

The fact that most men don't notice they are losing hair until they've lost 40% density just shows that the majority of men are terrible at spotting subtle changes in their body.

If they actually measured sexual performance in a scientific manner then the occurrence of sexual side effects would be almost 100%
a "scientific" way lol novody has ever done thie not even studies that are fundamentally about penile health. you sound like sone mad man on crack
 

badnewsbearer

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How do you come to this conclusion?
he made it up. sure there is issues with the IIEF vut it is not used jist in those trials, it is used everywhere when you want to getbinfo about sexual function be it penile surgery or how well cialis works its akways the same test
 

badnewsbearer

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Right, I have no idea what I'm talking about because you personally think the merck researchers should have been in there measuring dicks. The definition of erectile disfunction is the inability to get or maintain an erection, so why would the researchers be doing some dick measuring and watching hard-ons with a stop watch instead of just asking for the most obvious markers which would be self reported instances of sexual dysfunction.

"Scientific manner" :p you're a joke bud. Find me a general study (ie not viagara or an erection drug) on the planet that is measuring dicks to determine sexual impairment. Better yet, find me a "side" outside of blood pressure or a blood metric that is determined without self reporting in a clinical trial.
you are correct and he is a pseduo researcher on a trip, all studies btw even those on cialie, v****, penile surgery(peyronies surgery etc) use the IIEF scale. sure that coukd be better but it is scientific enoigh for the most erection based resewech out there, this hws nothinf to do with finasteride trials. if over a large sample group you have no change in the IIEF you can assume it causes no ED thats how statistics works. the stop watch comment is comical, for me my ED on finasteride if it was just a stop watch thing itd be fine, if i do the IIEF there is a clead drop in pointw, very obvious if you actually look at the test which he has never done probabbly
 

MaestroTR

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Do you think this will be enough to halt the loss or we will still need finasteride?
 

Kagaho

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Kintor is really comitted to KX-826
Lets hope they start phase 2 in USA ASAP

Also it would be awesome if they disclose GT20029 phase 1 results this quarter. We really need a drug like that.
 
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Dimitri001

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Source? It can only induce things that can be psychological. If stress is a factor then placebo can help. Stress does not cause Androgenetic Alopecia. No placebo can reverse a genetic disease.
I did some quick googling and it seems you may be right.

Google says placebo can alter heart rate and blood pressure, but those can be controlled by changes in psychological state.

There is this article which has things like this:

McKenzie (1896) reported an interesting ob-
servation relevant to the understanding of the
placebo effect in the immune system. In this
study, it was shown that some people who are
allergic to flowers show an allergic reaction
when presented with something that super-
ficially looks like a flower, but contains no
pollen (i.e., an artificial flower).


But the presumed mechanism there is classic Pavlovian conditioning, not placebo.

I did a bit of reading on placebo some years ago and I could have sworn I'd read about actual physical effects, but perhaps I misremembered, my bad.
 

Baldingtooyoung

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Cardinal~

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Yeah wasnt there some results expected to come out before the end of 2021? What happened to them?
 

5minutesbeforemiracle

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Some have theorised that CB wasn't as effective at 12 months compared to 6 months due to AR-upregulation when using AA. Pyrilutamide phase 3 study is only 6 months so we can't know for sure if something similar will happen here. Does anyone have any theories?
 

Kagaho

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Some have theorised that CB wasn't as effective at 12 months compared to 6 months due to AR-upregulation when using AA. Pyrilutamide phase 3 study is only 6 months so we can't know for sure if something similar will happen here. Does anyone have any theories?

Not likely. RU users (and macaque studies corroborates that) have reported long lasting benefits from it and both have the same MOA.

Pyrilutamide binding affinity to AR is like 4x RU so i wouldnt expect that to happen. CB may just not be potent enough to hold the gains.
 
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fashy

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This 1 year delay of the results + the lack of information or action in regards to the phase II FDA trial (considering the trial was greenlit last June and Kintor usually moves much faster than this) has me just slightly worried. Hopefully it's nothing significant.
 

5minutesbeforemiracle

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Not likely. RU users (and macaque studies corroborates that) have reported long lasting benefits from it and both have the same MOA.
Actually, there is a noted lack of RU results. If you google previous posts about RU on this forum, you'll see that people have been lamenting lack of evidence/results of RU for years now. Only that MPMD guy (who gets commissions on RU sales) seems to have gotten great results.
Well, I don't want to derail this thread by talking about RU too much, but the AR upregulation is still a genuine concern. As you say, though, pyrilutamide is a lot more efficacious than RU so it might be able to have long-term results.
 
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