decro435
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I think I've come to a conclusion on Androgentic Alopecia. I've come to believe that it is all to do with inflammation. The most aggressive male pattern baldness sufferer's have the worst inflammation. This is that "itch" in the thinning areas. While the people who have slower male pattern baldness might not feel any itch. That is not to say it's not there, it just isn't as aggressive.
DHT is the cause of the inflammation and inflammation is the cause of the hair loss. Chronic systemic inflammation has been found to at the root of many serious disorders, such as cardiovascular disease, asthma, arthritis, cancer, diabetes, depression and androgentic Alopecia.
Taken from male pattern baldness Reseatch.org:
""These “age related†disorders are accompanied by a pathological increase of inflammatory cytokines. Lowering pro-inflammatory cytokines, such as tumor necrosis factor –alpha, interleukin – 6, interleukin 1(B) and/or interleukin B4, could help prevent and treat many age related diseases. After several published studies, which showed that inflammation is present in androgenetic alopecia, male pattern baldness Research reported these important findings to readers, particularly stressing the need to address inflammation in any hair loss treatment approach, including our recommended protocol. Excessive levels of cytokines can be systemically and topically countered by an appropriate regimen of drugs, nutrients, dietary changes, and/or hormones. For example, fish oil has been shown to effectively lower these levels, as does DHEA, Nettle extract, GLA, and some antioxidants (vitamin E and N-acetyl cysteine). Meanwhile certain herbal extracts patented by Asian companies, Emu oil, copper peptides and ketoconazole can be used to topically partially inhibit cytokine formation. Following is an extensive analysis (in layman’s terms) that makes the connection between inflammation, and the “programmed cell death†of the hair follicle, a process known as “apoptosisâ€. It is partially based upon input from Waseda, a Japanese researcher who has been researching inflammation and androgenetic hair loss for many years. He has been able to initiate extensive hair regrowth after being a “slick bald†Norwood 5 for many years using an aggressive combination of therapies specifically designed to counter inflammation and an apoptosis factors.
TOWARDS A COMPREHENSIVE TREATMENT OF male pattern baldness
First we must recognize that hair loss is the consequence of hair cell apoptosis, or programmed cell death. Apoptosis is the final result of what is termed the caspase activation cascade. Essentially DHT, superoxide, and other free radicals damage the cell’s mitochondria, and the damaged mitochondria in turn vomits cytochrome C, which activates the caspase 9 cascade. TGF-beta and alpha activate caspase 9 around hair follicles. The activated caspase 9 propagates downstream into caspase 3. Activation of caspase 3 is thought to be a direct cause of cell apoptosis (programmed cell death) in general. What then causes a caspase activation cascade and how can one intervene in the context of hair loss?
Protein Kinase C (PKC) as an executor of apoptosis PKC isozymes are involved in the final execution of hair cell apoptosis in relation to caspase 3. What are good inhibitors of PKC? Cycloporin (dangerous), Grape Seed Extract, Resveratrol (as in red wine), Vitamin E, and N-Acetyl Cysteine. Topically, Grape Seed Extract (a patented treatment for hair loss), and Perilla Leaf Extract.
Tumor Necrosis Factor Alpha (TNF-a) as a promotor of PKC and hair cell apoptosis. TNF-a induces the PKC isozymes and causes cell death through this induction. This pathway is known to be a major cause of hair loss. TNF-a is a quick acting proinflammatory cytokine, and TNF-a is over secreted in cases of rapid hair loss. How can TNF-a be safely inhibited? Ginkgo Biloba Extract, Stinging Nettle Extract, Green Tea Extract, and essential fatty acids found in fish, Emu, Borage, and Perilla oils. Topically, Perilla leaf extract may be useful.
TGF-Family as the bridge between DHT and the activation of the caspase cascade. In recent studies researchers have found DHT promotes TGF, and TGF causes activation of the caspase cascade and thus, hair cell death, which clinically manifests as male and female pattern baldness. What inhibits TGH safely, as opposed to the dangerous anti-cancer compounds? Proteolytic Enzymes such as a bromelain, and the anti-oxidant Curcumin are TGF inhibitors. Shiseido, a Japanese cosmetic company found that Amacha, a sugar alternative found in the orient has TGF inhibition properties. Dr. Sawaya’s latest study about finasteride suggests that the best hair loss prevention would involve the blocking of caspase activation, especially caspase 3. Caspase 3 is the direct cause of programmed hair cell death (apoptosis) that originates “upstreamâ€. The first triggers may be DHT damage or oxidative (free radical) stress on the mitochondria, TGF induction from DHT, TNF-A induction from allergic inflammation, or PKC upregulation by caspase activation. Here we can summarize the rationale behind the treatments of various pro-inflammatory mechanisms.
DHT inhibition- Finasteride, Saw Palmetto, Rivoflavin, Green Tea Extract, Copper Peptides, and Topical Bayberry Extract.
PKC down regulation - Grape Seed Extract, Resveratrol, Vitamin E, Soy Isoflavones.
TNF-a down regulation- Curcumin, Ginkgo Biloba Extract, Stinging Nettle Extract, Green Tea Extract, Fish Oil, Borage Oil, Perilla Oil, and Topical Perilla leaf extract.
TGF down regulation- Curcumin, and topical Amacha.
Taking into account the inhibition of hair apoptosis factors, it is apparent that treatment can be taken to a new level. Again, Waseda himself is experiencing regrowth in all areas of his scalp after being a slick bald “Norwood 5†for many years.""
While we cannot fully stop the immune response, we can decrease it and thus minimize hair loss. I was informed of a study which showed two islanders in which one ate a pro-inflammatory diet and one which ate a more natural diet. The one with the more natural diet showed no signs of hair loss and the one with the "civilized" diet did. While this is in no way an impressive conclusion it is interesting. The problem isn't our diet though, it's our genetic predisposition to male pattern baldness. Our follicles are more sensitive to DHT and as it "chokes" our follicles it induces an immune response which destroys the follicle. This is the reason why Finasteride works, unfortunately we are not directly attacking the cause. I cannot clearly dwell into the science in this because I honestly don't understand it. But, it seems many others do. There have been countless references to inflammation and it's role in Androgenetic Alopecia.
Taken from Wikipedia:
""Inflammation
For more details on this topic, see Inflammation.
Inflammation is one of the first responses of the immune system to infection.[19] The symptoms of inflammation are redness and swelling, which are caused by increased blood flow into a tissue. Inflammation is produced by eicosanoids and cytokines, which are released by injured or infected cells. Eicosanoids include prostaglandins that produce fever and the dilation of blood vessels associated with inflammation, and leukotrienes that attract certain white blood cells (leukocytes).[20][21] Common cytokines include interleukins that are responsible for communication between white blood cells; chemokines that promote chemotaxis; and interferons that have anti-viral effects, such as shutting down protein synthesis in the host cell.[22] Growth factors and cytotoxic factors may also be released. These cytokines and other chemicals recruit immune cells to the site of infection and promote healing of any damaged tissue following the removal of pathogens.""
If you read over the first quote I posted, you will see that that article lowering pro-inflammatory cytokines will address the the problem more directly. This is one of the reasons why Ketoconazole in Nizoral works. It partially inhibits Cytokine formation.
This study claims that both inflammation and fibrosis play in Androgenetic Alopecia. It implies that the role played by inflammation and fibrosis is more central to hair loss than the hormonal initiators, namely DHT and Androstenedione:
http://www.hairloss-research.org/LinkUp ... e7-09.html
I understand that the thought of changing your diet is an retarded naturalist way to and male pattern baldness cure, but a regimen like in the first post could be the key:
DHT inhibition- Finasteride, Saw Palmetto, Rivoflavin, Green Tea Extract, Copper Peptides, and Topical Bayberry Extract.
PKC down regulation - Grape Seed Extract, Resveratrol, Vitamin E, Soy Isoflavones.
TNF-a down regulation- Curcumin, Ginkgo Biloba Extract, Stinging Nettle Extract, Green Tea Extract, Fish Oil, Borage Oil, Perilla Oil, and Topical Perilla leaf extract.
TGF down regulation- Curcumin, and topical Amacha.
I realise though that this will not be enough to help me, because my hair loss is premature as I have a high predeposition to Androgentic Alopecia. But for people who have less aggressive hair loss it could really help. Do your own research on inflammation and it's role in Male Pattern Baldness and discover for yourself.
I saw a decrease in inflammation when using a much smaller version of this regimen. Unsurprisingly, I also saw a decrease in hair loss. In this regimen I had not included any DHT-inhibiting properties. The problem was my anti-inflammatory regimen was not potent enough. I hope to upgrade soon.
Another reason I like to promote this anti-inflammatory regimen is because there are so many other illnesses caused my this, serious disorders such as cardiovascular disease, asthma, arthritis, cancer, diabetes, depression and androgentic Alopecia. Olive oil and the Mediterranean Diet is an anti-inflammatory diet. The longest living woman in the world claimed she used olive oil for everything, on her skin and hair and in her food. She hadn't lost any of her hair at 122. Interesting...
DHT is the cause of the inflammation and inflammation is the cause of the hair loss. Chronic systemic inflammation has been found to at the root of many serious disorders, such as cardiovascular disease, asthma, arthritis, cancer, diabetes, depression and androgentic Alopecia.
Taken from male pattern baldness Reseatch.org:
""These “age related†disorders are accompanied by a pathological increase of inflammatory cytokines. Lowering pro-inflammatory cytokines, such as tumor necrosis factor –alpha, interleukin – 6, interleukin 1(B) and/or interleukin B4, could help prevent and treat many age related diseases. After several published studies, which showed that inflammation is present in androgenetic alopecia, male pattern baldness Research reported these important findings to readers, particularly stressing the need to address inflammation in any hair loss treatment approach, including our recommended protocol. Excessive levels of cytokines can be systemically and topically countered by an appropriate regimen of drugs, nutrients, dietary changes, and/or hormones. For example, fish oil has been shown to effectively lower these levels, as does DHEA, Nettle extract, GLA, and some antioxidants (vitamin E and N-acetyl cysteine). Meanwhile certain herbal extracts patented by Asian companies, Emu oil, copper peptides and ketoconazole can be used to topically partially inhibit cytokine formation. Following is an extensive analysis (in layman’s terms) that makes the connection between inflammation, and the “programmed cell death†of the hair follicle, a process known as “apoptosisâ€. It is partially based upon input from Waseda, a Japanese researcher who has been researching inflammation and androgenetic hair loss for many years. He has been able to initiate extensive hair regrowth after being a “slick bald†Norwood 5 for many years using an aggressive combination of therapies specifically designed to counter inflammation and an apoptosis factors.
TOWARDS A COMPREHENSIVE TREATMENT OF male pattern baldness
First we must recognize that hair loss is the consequence of hair cell apoptosis, or programmed cell death. Apoptosis is the final result of what is termed the caspase activation cascade. Essentially DHT, superoxide, and other free radicals damage the cell’s mitochondria, and the damaged mitochondria in turn vomits cytochrome C, which activates the caspase 9 cascade. TGF-beta and alpha activate caspase 9 around hair follicles. The activated caspase 9 propagates downstream into caspase 3. Activation of caspase 3 is thought to be a direct cause of cell apoptosis (programmed cell death) in general. What then causes a caspase activation cascade and how can one intervene in the context of hair loss?
Protein Kinase C (PKC) as an executor of apoptosis PKC isozymes are involved in the final execution of hair cell apoptosis in relation to caspase 3. What are good inhibitors of PKC? Cycloporin (dangerous), Grape Seed Extract, Resveratrol (as in red wine), Vitamin E, and N-Acetyl Cysteine. Topically, Grape Seed Extract (a patented treatment for hair loss), and Perilla Leaf Extract.
Tumor Necrosis Factor Alpha (TNF-a) as a promotor of PKC and hair cell apoptosis. TNF-a induces the PKC isozymes and causes cell death through this induction. This pathway is known to be a major cause of hair loss. TNF-a is a quick acting proinflammatory cytokine, and TNF-a is over secreted in cases of rapid hair loss. How can TNF-a be safely inhibited? Ginkgo Biloba Extract, Stinging Nettle Extract, Green Tea Extract, and essential fatty acids found in fish, Emu, Borage, and Perilla oils. Topically, Perilla leaf extract may be useful.
TGF-Family as the bridge between DHT and the activation of the caspase cascade. In recent studies researchers have found DHT promotes TGF, and TGF causes activation of the caspase cascade and thus, hair cell death, which clinically manifests as male and female pattern baldness. What inhibits TGH safely, as opposed to the dangerous anti-cancer compounds? Proteolytic Enzymes such as a bromelain, and the anti-oxidant Curcumin are TGF inhibitors. Shiseido, a Japanese cosmetic company found that Amacha, a sugar alternative found in the orient has TGF inhibition properties. Dr. Sawaya’s latest study about finasteride suggests that the best hair loss prevention would involve the blocking of caspase activation, especially caspase 3. Caspase 3 is the direct cause of programmed hair cell death (apoptosis) that originates “upstreamâ€. The first triggers may be DHT damage or oxidative (free radical) stress on the mitochondria, TGF induction from DHT, TNF-A induction from allergic inflammation, or PKC upregulation by caspase activation. Here we can summarize the rationale behind the treatments of various pro-inflammatory mechanisms.
DHT inhibition- Finasteride, Saw Palmetto, Rivoflavin, Green Tea Extract, Copper Peptides, and Topical Bayberry Extract.
PKC down regulation - Grape Seed Extract, Resveratrol, Vitamin E, Soy Isoflavones.
TNF-a down regulation- Curcumin, Ginkgo Biloba Extract, Stinging Nettle Extract, Green Tea Extract, Fish Oil, Borage Oil, Perilla Oil, and Topical Perilla leaf extract.
TGF down regulation- Curcumin, and topical Amacha.
Taking into account the inhibition of hair apoptosis factors, it is apparent that treatment can be taken to a new level. Again, Waseda himself is experiencing regrowth in all areas of his scalp after being a slick bald “Norwood 5†for many years.""
While we cannot fully stop the immune response, we can decrease it and thus minimize hair loss. I was informed of a study which showed two islanders in which one ate a pro-inflammatory diet and one which ate a more natural diet. The one with the more natural diet showed no signs of hair loss and the one with the "civilized" diet did. While this is in no way an impressive conclusion it is interesting. The problem isn't our diet though, it's our genetic predisposition to male pattern baldness. Our follicles are more sensitive to DHT and as it "chokes" our follicles it induces an immune response which destroys the follicle. This is the reason why Finasteride works, unfortunately we are not directly attacking the cause. I cannot clearly dwell into the science in this because I honestly don't understand it. But, it seems many others do. There have been countless references to inflammation and it's role in Androgenetic Alopecia.
Taken from Wikipedia:
""Inflammation
For more details on this topic, see Inflammation.
Inflammation is one of the first responses of the immune system to infection.[19] The symptoms of inflammation are redness and swelling, which are caused by increased blood flow into a tissue. Inflammation is produced by eicosanoids and cytokines, which are released by injured or infected cells. Eicosanoids include prostaglandins that produce fever and the dilation of blood vessels associated with inflammation, and leukotrienes that attract certain white blood cells (leukocytes).[20][21] Common cytokines include interleukins that are responsible for communication between white blood cells; chemokines that promote chemotaxis; and interferons that have anti-viral effects, such as shutting down protein synthesis in the host cell.[22] Growth factors and cytotoxic factors may also be released. These cytokines and other chemicals recruit immune cells to the site of infection and promote healing of any damaged tissue following the removal of pathogens.""
If you read over the first quote I posted, you will see that that article lowering pro-inflammatory cytokines will address the the problem more directly. This is one of the reasons why Ketoconazole in Nizoral works. It partially inhibits Cytokine formation.
This study claims that both inflammation and fibrosis play in Androgenetic Alopecia. It implies that the role played by inflammation and fibrosis is more central to hair loss than the hormonal initiators, namely DHT and Androstenedione:
http://www.hairloss-research.org/LinkUp ... e7-09.html
I understand that the thought of changing your diet is an retarded naturalist way to and male pattern baldness cure, but a regimen like in the first post could be the key:
DHT inhibition- Finasteride, Saw Palmetto, Rivoflavin, Green Tea Extract, Copper Peptides, and Topical Bayberry Extract.
PKC down regulation - Grape Seed Extract, Resveratrol, Vitamin E, Soy Isoflavones.
TNF-a down regulation- Curcumin, Ginkgo Biloba Extract, Stinging Nettle Extract, Green Tea Extract, Fish Oil, Borage Oil, Perilla Oil, and Topical Perilla leaf extract.
TGF down regulation- Curcumin, and topical Amacha.
I realise though that this will not be enough to help me, because my hair loss is premature as I have a high predeposition to Androgentic Alopecia. But for people who have less aggressive hair loss it could really help. Do your own research on inflammation and it's role in Male Pattern Baldness and discover for yourself.
I saw a decrease in inflammation when using a much smaller version of this regimen. Unsurprisingly, I also saw a decrease in hair loss. In this regimen I had not included any DHT-inhibiting properties. The problem was my anti-inflammatory regimen was not potent enough. I hope to upgrade soon.
Another reason I like to promote this anti-inflammatory regimen is because there are so many other illnesses caused my this, serious disorders such as cardiovascular disease, asthma, arthritis, cancer, diabetes, depression and androgentic Alopecia. Olive oil and the Mediterranean Diet is an anti-inflammatory diet. The longest living woman in the world claimed she used olive oil for everything, on her skin and hair and in her food. She hadn't lost any of her hair at 122. Interesting...
