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It doesn't matter. You're balding due to excessively high androgens, not due to lack of estrogen.
Interesting. I wonder why this hasn’t been used to diagnose balding early... according to this if you try HRT with epitest would that solve this imbalance?
Do you know why balding people have such a bad T/epiT ratio in their follicles or have any leads on how to counteract it?
Wow that makes me feel like absolute sh*t. Like the hair loss research community backed the wrong horse.It's not available in significant enough quantities anywhere to actually do this. Even if you did, you would have the same side effects as if you used most other anti-androgens, remember that the ratio is fine in serum. It's only broken in the hair follicle. So you still have the same problem of wanting to limit the action only to your hair follicles just as with all other medication, and don't want systemic absorption.
It's not entirely sure how epitestosterone is synthesized yet, although a single study claims the proposed pathway is this:
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4-dione is androstenedione which is normally converted by 17b-HSD into testosterone. It would make sense that 17a-HSD would convert it into epitestosterone. It is reasonable to presume that there is an imbalance between these two enzymes in the balding follicles which greatly favors 17beta-HSD metabolism. As to why, perhaps that is the 'genetic' part. Maybe there is a better reason but research on this angle is limited and has been dead for about 15 years, unfortunately. The current research is focused on prostaglandins, WNT and other downstream effects which pale in comparison to having proper hormone balance in the first place. We could have known everything about the Androgenetic Alopecia follicle steroid balance by now - perhaps a selective 17b-HSD inhibitor could've been synthesized, or a way to induce 17a-HSD activity back to normal in the follicle.
Estrogen grows hair, period. Epitestosterone is a locked door, that's a feature of preadolescence.
You're ignoring the fact that balding people have on average a 5 times higher ratio of T / Epi-T in their balding follicles compared to non-balding people, their entire life - this has nothing to do with preadolescence or serum levels. This is a localized hormonal imbalance.
I know I'm starting to sound like an annoying broken record but that doesn't sound like test was the issue at all. Was he at all by chance taking aggressive aromatase inhibitors as well?
If you've kept your hair mostly barring some gradual attrition through out your late teenage years into your twenties, it should not be merely that hormone which has been circulating in your body for all that time which suddenly and completely decimates your hair regardless of where it is. Something else is clearly at play.
It doesn't work like that. E2 is proportional with T. The higher the T, the higher the E2, until you'll find a plateau and T will start increasing and E2 will stay the same. But it doesn't happen in naturals.What I can say though is that I believe my estrogen levels were significantly higher, I think that's a far safer assumption than saying a 30 year old man was still retaining high epitestosterone expression in his follicles.
It doesn't matter, if epitestosterone levels are higher when you're preadolescent, then it is in effect a locked door and I guarantee you any research or treatment pathway that focuses on that will be so ungodly expensive that it won't be viable for common consumers.
My hypothesis is that in the case of most men you simply don't need to force your body to emulate the functioning of a prepubescent boy to regrow hair.
By the time I was 30 I had full regrowth, my hair was about as thick as it was when I was in my teens. There's no way even with my somewhat predisposition for genetic vulnerability to hairloss that somehow magically the testosterone I was exposed to all through my 20s either started or stopped working based on my hair loss or regrowth.
What I can say though is that I believe my estrogen levels were significantly higher, I think that's a far safer assumption than saying a 30 year old man was still retaining high epitestosterone expression in his follicles.
I plan on going the topically applied low dose estrogen route, I will report back my findings, but I have a very strong suspicion that the again relapse hairloss of the last two years I've experienced is due to an imbalance where the ratio of my estrogen to testosterone has faltered and no amount of nuking my DHT levels seems to have helped this.
What's the status of inter-sex people and hair loss in general? Seems like a good path for research as are the T and DHT levels of say, the Inuit and Native American people who seem to have little or no differences in the hair patterns between males and females.
This is all much more complicated in terms of endocrine activity than we want to acknowledge and changes to one aspect, say to beards, might throw off other aspects. Some have alleged a link between minoxidil usage for beards and hair loss on top subsequently.I've read plenty of stories of people having worse hairlines on duta. But at the same time, some have improved hair everywhere including the hairline on duta. So what gives?
What did he do though? Has he just fluffed his hair and colored it? Or did he have a transplant imposed on what he already had? I note that he, Biden and Trump all have serious hair issues apparently related to the psychological effects of hair loss as did Caesar and several Emperors so maybe the rest of us ordinary mortals need not feel guilty for mourning our locks!Hahahaha good points. That guy always creeps me out.
I have become cognizant of looking at all historic persons in terms of hair and beard growth. Beard grooming and extensive beards were a huge deal in the 19th century and that probably does help the male ego some in terms of having something to groom and compete with others with. Many of the beard patterns back then were ornate and "dandy-like" in my opinion. It continues to be striking just how bald many of the well-known Western European males have been throughout history and in general. That's why, I think, that people like Brad Pitt and Oscar Wilde are so striking to many of us in terms of how they present when virtually no one else past 18 years of age is able to do so in a comparable way. Wilde was 6 feet three inches tall and it is not hard to see why he might have been esteemed for his appearance:Hahahah. I love how that guy, Trump, and Biden all have done things to try and compensate for their hair. Meanwhile Putin has the IDGAF attitude going on xD. And then there's Kim and the chinese guy with the perfect hair lol
Native American are just not susceptible to hair loss, don't have hair loss genes, probably doesn't matter what their androgen tissue levels are.What's the status of inter-sex people and hair loss in general? Seems like a good path for research as are the T and DHT levels of say, the Inuit and Native American people who seem to have little or no differences in the hair patterns between males and females.
It would be interesting to see what the hair loss effects of T supplementation on Native American hair might be. Perhaps it's a threshold issue and at some levels effects would be noticed. I assume they don't suffer from acne among N.I.'s either.Native American are just not susceptible to hair loss, don't have hair loss genes, probably doesn't matter what their androgen tissue levels are.