waynakyo
Experienced Member
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[h=1][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles.[/FONT][/h][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Ryu S1, Lee Y2, Hyun MY3, Choi SY4, Jeong KH5, Park YM6, Kang H7, Park KY8, Armstrong CA9, Johnson A10, Song PI11, Kim BJ12.[/FONT]
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Author information[/FONT][/h]
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Abstract[/FONT][/h][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Recently, various immunosuppressant drugs have been shown to induce hair growth in normal hair as well as in alopeciaareata and androgenic alopecia; however, the responsible mechanism has not yet been fully elucidated. In this study, we investigate the influence of mycophenolate (MPA), an immunosuppressant, on the proliferation of human dermal papilla cells (hDPCs) and on the growth of human hair follicles following catagen induction with interferon (IFN)-γ. IFN-γ was found to reduce β-catenin, an activator of hair follicle growth, and activate glycogen synthase kinase (GSK)-3β, and enhance expression of the Wnt inhibitor DKK-1 and catagen inducer transforming growth factor (TGF)-β2. IFN-γ inhibited expression of ALP and other dermal papillar cells (DPCs) markers such as Axin2, IGF-1, and FGF 7 and 10. MPA increased β-catenin in IFN-γ-treated hDPCs leading to its nuclear accumulation via inhibition of GSK3β and reduction of DKK-1. Furthermore, MPA significantly increased expression of ALP and other DPC marker genes but inhibited expression of TGF-β2. Therefore, we demonstrate for the first time that IFN-γ induces catagen-like changes in hDPCs and in hair follicles via inhibition of Wnt/β-catenin signaling, and that MPA stabilizes β-catenin by inhibiting GSK3β leading to increased β-catenin target gene and DP signature gene expression, which may, in part, counteract IFN-γ-induced catagen in hDPCs.[/FONT]
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I would be very interested in the literature backing their claim in the first sentence. Encouraging.
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Author information[/FONT][/h]
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Abstract[/FONT][/h][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Recently, various immunosuppressant drugs have been shown to induce hair growth in normal hair as well as in alopeciaareata and androgenic alopecia; however, the responsible mechanism has not yet been fully elucidated. In this study, we investigate the influence of mycophenolate (MPA), an immunosuppressant, on the proliferation of human dermal papilla cells (hDPCs) and on the growth of human hair follicles following catagen induction with interferon (IFN)-γ. IFN-γ was found to reduce β-catenin, an activator of hair follicle growth, and activate glycogen synthase kinase (GSK)-3β, and enhance expression of the Wnt inhibitor DKK-1 and catagen inducer transforming growth factor (TGF)-β2. IFN-γ inhibited expression of ALP and other dermal papillar cells (DPCs) markers such as Axin2, IGF-1, and FGF 7 and 10. MPA increased β-catenin in IFN-γ-treated hDPCs leading to its nuclear accumulation via inhibition of GSK3β and reduction of DKK-1. Furthermore, MPA significantly increased expression of ALP and other DPC marker genes but inhibited expression of TGF-β2. Therefore, we demonstrate for the first time that IFN-γ induces catagen-like changes in hDPCs and in hair follicles via inhibition of Wnt/β-catenin signaling, and that MPA stabilizes β-catenin by inhibiting GSK3β leading to increased β-catenin target gene and DP signature gene expression, which may, in part, counteract IFN-γ-induced catagen in hDPCs.[/FONT]
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I would be very interested in the literature backing their claim in the first sentence. Encouraging.
