Great work.I got a few very answers from their chief scientist! She seems to be quite a nice person who actually cares about baldies. Here are the most important questions and answers.
Q: May I ask you a question? Did you guys gather any evidence so far that the treatment actually works on humans? As I guess similar methods like Intercytex had mediocre results in humans. However, I think what you are trying to do is to do 3d culturing such that the cells do not lose their inductive properties, i.e. can be used for hair rejunevation.
Thank you, I really think what we’re doing could really help. There is evidence in mice and in humans that this works. Mouse work is not really great because human hairs are quite different but the work Aderans research did showed some good effects. The CEO of Intercytex is the CEO of HairClone. I am quite new to the business world, but it takes more than just good science to be successful. Back in 2003(ish) they were trying to grow new hairs. They did not show many new hairs but showed thickening of the hairs that are starting to become thinner. Because this was not their primary end point, it was not deemed a success. The difference now is that we are targeting hairs undergoing thinning, not trying to make brand new hairs. A clinical trial can succeed or fail based purely on patient selection. We will be much more informed on who to select going forward and therefore much more likely to show it works. The ones that are still actively miniaturising are what we are targeting. Those ones become thicker. In the trials that went on, they chose people with bald patches mainly. We believe our therapy will help those that have just started to thin restore and retain thick hair. It’s fascinating to see things from the business side too. I thought “why would they drop this approach if it is showing success?” And the answer is a) it didn’t show much NEW hair growth, which is what they were aiming for and b) the company was bought by a company who made a lot of money from wigs and hair transplants (Bosely). Research is expensive so they dropped it.
It is difficult to get funding to do this work because it is considered cosmetic. And I have had messages saying I should do something more important like cancer research or heart research. Funnily enough, I spent 10 years doing cancer research and feel like I have a better chance of actually improving peoples’ lives doing what I am now. I also get a lot of messages from people who are depressed and have low self esteem because of hair loss. It’s a large part of a person’s identity. I can very much relate.
Q: okay a question I've always asked myself is pretty much (not directly related to your company though): Do you think that hair follicles just go dormant or they actually "die"? I think I have seen a few cases on transgender women who have regained a lot of their hair after years of baldness.
A: Hair follicles seem to keep getting thinner and thinner until they just don’t have the capacity to generate a hair anymore. So i believe there is a residual follicle there, it just doesn’t have the capacity to do anything.
Transgender women are the only people who can get hair transplants on the NHS. For the very reason that it is so fundamental to a person’s identity
I see! Wow I am actually very impressed by how much you care. I do not know if you are aware of this but there are a few blogs dedicated to hair loss which wrote about your company (folliclethought/hairlosscure2020).
I’m very motivated by the thought of helping improve so many peoples’ lives. It bothered me that cancer research is all about extending life (because it’s a definitive measurement) when really quality of life is extremely important too
Follicle thought is excellent. Our CEO talks to Joe quite often to give him updates
Q: There was quite a hype when the Ceo announced that you would start treating patients early 2022 in UK only, but obviously there was a little bit of scepticism, because there weren't any new treatments since rogaine/finasteride were approved 20+ years ago, and there was a lot of straight up charlatanism in the next decade. I suppose people tried to monetarize on people's fears too much, this is why I think there is some scepticism on a treatment which did not show efficacy on humans yet.
It’s horrible how many people just lie and say they will be able to treat people soon when really it’s years away. Unfortunately, Covid got in the way of us validating our cell growing method in the manufacturing facility, which was due to begin July. Once validated, we can start to test in people in the UK. I do not blame people who are sceptical when so much has been promised. The issues lie in funding the test treatments, but once efficacy has been shown, I have no doubt things will take off. We need to work to make the process more efficient and less costly.
Q: Yeah people are super sceptical for sure, but I guess when the results are there they are there, right.
A: Yes, we just need to convince people with money to pay for the experiments to show that it works! That’s the barrier
Q: yeah, I mean this probably depends on the price right? I wouldn't spend 10k too if I don't know if it works, but I guess people waste thousands of bucks for prp, so why not give it a try at least?
A: Well, to begin with, we need to test on people so it’ll be free to them, but the money needs to come from investment somewhere! Then if it’s successful, we can charge and go from there.
Q: I really think things start to look promising! There are many companies and angles this problem is tackled from. I cheer for you guys (and Kintor, hope they manage to create an antiandrogen without side effects)
I wonder whether finasteride injections could provide that. That would be great! There are shampoos that claim to block DHT but they do not. There is so much false information out there when it comes to hair loss. Quite horrible.
So they are using their old research not to grow new hairs but to improve current ones. Which is great. Wonder if sideless maintance is on the table here.