Finasteride taking leads to allopregnanolone depletion in human brain | HairLossTalk Forums

Finasteride taking leads to allopregnanolone depletion in human brain

Discussion in 'Dealing with Side Effects' started by Fanjeera, Dec 16, 2012.

  1. Fanjeera

    Fanjeera Senior Member

    Joined:
    Jun 15, 2008
    Messages:
    1,216
    Likes Received:
    44
    Dislikes Received:
    3
    Because 5ar2 is also found in the human brain (http://www.hindawi.com/journals/au/2012/530121/tab3/) taking finasteride will have an effect on it due to allopregnanolone depletion (http://www.lf1.cuni.cz/Data/Files/PragueMedicalReport/pmr_110_2009_03/pmr2009a0025.pdf ; http://www.degruyter.com/view/j/hmbci.2010.1.issue-2/hmbci.2010.010/hmbci.2010.010.xml). Allopregnanolone is needed for neurogenesis, studying, stress control and probably many other stuff, if you start reading studies (http://www.ncbi.nlm.nih.gov/pubmed/20486040). Alzheimer's, Parkinson's and depression patients also have low levels of allopregnanolone.
    http://en.wikipedia.org/wiki/Allopregnanolone

    So stop taking it and hope you get your allopregnanolone back, because your neurons need it!

    - - - Updated - - -

    http://www.lf1.cuni.cz/Data/Files/PragueMedicalReport/pmr_110_2009_03/pmr2009a0025.pdf
    I don't understand why the link won't work in the first post. Try it here!
     
    Arrade likes this.
  2. Wuffer

    Wuffer Experienced Member

    Joined:
    Nov 12, 2010
    Messages:
    952
    Likes Received:
    45
    Dislikes Received:
    1
    These studies indicate that finasteride may induce depressive symptoms due to these effects. You are jumping to completely unfounded conclusions suggesting that Alzheimer's and Parkinson's may also result from finasteride use, and I construe that as fear mongering.

    Your first link actually reaches the opposite conclusion that you did. It actually said (with regards to 5AR-2): "not detected in fetal liver, adrenal, testis, ovary, scalp, and brain".

    You are using extremely simple and flawed logic (low allo levels may be linked to neurodegenerative disorders, and since finasteride lowers allo levels, finasteride causes these disorders). None of these studies say that finasteride may cause anything other than depressive symptoms, which is something we already know. Also, none of these show that finasteride lowers allo levels in the brain in humans. Even if this is the case, how much does it lower it, exactly? How much is dangerous? How do we know that slightly lowering allo levels is dangerous, or that it isn't actually protective? We know that high cholesterol is unhealthy, but so is low cholesterol. There is so much we don't know about how the brain works. What's comforting to me as a finasteride user is that tens of thousands of men have been studied taking this stuff for years, and it's never been shown to cause any mental symptoms of any sort.

    Enough with the fear mongering. If you have some new, more concrete evidence that supports your theories, we would be glad to see it. Otherwise, this type of interpretation of small animal studies in attempt to scare people is best left at propeciahelp.
     
    Baldingat23 likes this.
  3. Fanjeera

    Fanjeera Senior Member

    Joined:
    Jun 15, 2008
    Messages:
    1,216
    Likes Received:
    44
    Dislikes Received:
    3
    This is pretty new info for me. Read the whole of the first link I posted. There's written (the +-s indicate it's positive staining in the brain): "Cerebral cortex: pyramidal c (++)". If 5ar2 wasn't found in the scalp, we would have no use of it :D. And not only should we be looking at 5ar2 now, but also 5ar3 which is also inhibited by finasteride.
    I have only come across studies that conclude, that low allopregnanolone no way good for the brain. Perhaps you're right, but I doubt it.
    Allopregnanolone is only made in the nervous system, since it's a neurosteroid (
    http://en.wikipedia.org/wiki/Neuroactive_steroid). Therefore, if we have get a reduction in the plasma due to finasteride, we most probably also lose it from our brains, because as we know, it hampers its production. Dihydroprogesterone to tetrahydroprogesterone is the same as testosterone to dihydrotestosterone. These processes are done by a reductase.

    But does it also comfort you that many respected doctors and professors are saying that post-finasteride syndrom exists and trying to find a solution for it? They even made a foundation:
    http://www.pfsfoundation.org/
     
  4. jason2045

    jason2045 New Member

    Joined:
    Apr 23, 2016
    Messages:
    7
    Likes Received:
    2
    Dislikes Received:
    0
    I tottaly recovered after serious side effect from finasteride with MUCUNA PRURIENS

    https://examine.com/supplements/mucuna-pruriens/

    hope it will help everyone like it did for me

    i really have massive libido, and big amount of sperm on ejaculation

    i had finasteride for 1 month and i notice side effect like no libido, no sexual appetite and i could not speak felt fog in front of my frontal bone and very big depression, and im all fine now
     
    Arrade and reyl like this.
  5. Saulus

    Saulus Experienced Member My Regimen

    Joined:
    Aug 14, 2017
    Messages:
    627
    Likes Received:
    586
    Dislikes Received:
    37
    My Regimen:
    My Regimen
    My Regimen
    "The biosynthesis of allopregnanolone in the brain starts with the conversion of progesterone into 5α-dihydroprogesterone by 5α-reductase type I. After that, 3α-hydroxysteroid dehydrogenase converts this intermediate into allopregnanolone.[2]Allopregnanolone in the brain is produced by cortical and hippocampus pyramidal neurons and pyramidal-like neurons of the basolateral amygdala"

    Do they write how much 1mg finasteride lowers allopregnanolone? For dht its 70% so it would be interesting to see especially when it comes to microdosing
     
    Arrade likes this.

Share This Page