New study:
RESULTS:
91 patients (median age 39, IQR 32-46) met inclusion criteria, 9.6% of men evaluated during this period. The most common SF symptom was ED in 95% (87/91). The mean IIEF-EF score was 14 ± 8.63 (n=81), consistent with severe (43%), mild-moderate (23%), moderate (12%), and mild (10%) ED. 57 underwent grayscale/Doppler ultrasound; 77% exhibited abnormal erectile tissue inhomogeneity. Mean cavernosal artery PSV/EDV values (n=61) were left 30.4±18.02/0.76±2.86 cm/sec and right 29.63±14.97/0.60±1.89 cm/sec, respectively. Concomitant orgasmic dysfunction and genital anhedonia/anesthesia were noted in 57% and 48%, respectively. These patients underwent QST testing (n=65) and 60% had abnormal results. On presentation, 30% had DHT ≤30 ng/dl, 16% had testosterone (T) ≤350 ng/dl, and 9% had calculated free T ≤6 ng/dl.
CONCLUSIONS:
In a large series, we replicated Khera’s findings of persistent physical sequelae associated with changes in SF in men after DC finasteride. While more research is needed, this population is young, ED is most often severe, and testing shows a high prevalence of vascular, neurologic and hormonal pathologies.