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Dr. Ying Zheng - CRTH2 PTGDR2 Antagonists Reverse the Hair Growth Inhibition

Discussion in '9th World Congress for Hair Research Conference' started by hellouser, Dec 16, 2015.

  1. hellouser

    hellouser Senior Member My Regimen

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  2. whatevr

    whatevr Senior Member My Regimen

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    What happened to AM211? There has been no news about it for the past 4 years.

    http://www.biocentury.com/products/am211

    Amira got bought out by Bristol Myers Squibb, who was supposed to continue development but it doesn't seem like anything is happening. Can't really find a place to buy it either. Another potentially useful chemical that got run into the ground.
     
  3. hellouser

    hellouser Senior Member My Regimen

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    No idea, but I suppose we should look into it. Dr. Cotsarelis already said to me in person a topical formulation of something like Setipiprant should work to block PGD2, so AM211 could be an alternative.
     
  4. HairlossCurse

    HairlossCurse New Member

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    I believe Kythera/Cotsarelis tested a number of GPR44 inhibitors and setitpirant turned out to be the most effective, thats why they bought the IP for it. Hopefully Kythera/Allergan will provide an update about the trials, they previously said they will start late 2015/ early 2016.

    Another thing I noticed was that, in the poster the way they prepared the blockers seemed pretty complex and I am pretty sure none of the home testers prepared the black market setitpirant properly.
     
  5. whatevr

    whatevr Senior Member My Regimen

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    95% ethanol / 3% glycerol / 2% (propylene/polyethylene? glycol) doesn't sound all that complex of a mixture.
     
  6. HairlossCurse

    HairlossCurse New Member

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    Yeah complex wasn't the word I was looking for, but it's different. I remember BTT members saying that Kane said that it wouldn't even dissolve in ethanol.
     
  7. HairlossCurse

    HairlossCurse New Member

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    In the poster it says

    "Hair follicles from a subset of alopecia patients exhibited no growth inhibition from PGD2, indication the existence of PDG2 responding and non responding individuals"

    So just confirming that the "alopecia" patients have Androgenetic Alopecia? Or could they have any form of hairloss? Because if they have Androgenetic Alopecia shouldnt 100% of patients respond to PGD2?

    Hellouser, do you have any more information on this?
     
  8. tizzleama

    tizzleama New Member

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  9. wickes

    wickes New Member

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    me too
     
  10. whatevr

    whatevr Senior Member My Regimen

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    Hellouser do you still have the poster that was accompanying this presentation? I'd love to take another look at it but the link expired.
     
  11. hellouser

    hellouser Senior Member My Regimen

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  12. whatevr

    whatevr Senior Member My Regimen

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    Thank you very much.

    If anyone's interested, Kane sells a CRTH2 Antagonist called TM30089 which is even more effective than Setipiprant and used in a low dose. For $140 you can buy several years worth of the stuff.
    It's also sold by a company called Rechemco.
     
  13. Afro_Vacancy

    Afro_Vacancy Senior Member My Regimen

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    Doesn't that stuff have a lot of side effects and a long half-life in the body?
     
  14. whatevr

    whatevr Senior Member My Regimen

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    https://www.caymanchem.com/pdfs/10006735.pdf


    If there are, I haven't seen any reported. Some people on german forum are testing it and no one said anything bad about it yet. The half life is less than 24 hours apparently but I can't yet give you a source for that.
     

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