DPC/DSC plus wound restores hair

[IDW2BB]

Pretty amazing stuff and could be just what the hair transplant's are looking for. Since the hair is still there
even in the bald scalp, I wonder if an accurate wound plus both DPC/DSC injected could restore the miniaturized hair?




http://www.ncbi.nlm.nih.gov/pubmed/25689375

Enhanced restoration of in situ-damaged hairs by intradermal transplantation of trichogenous dermal cells.
Yamao M1, Inamatsu M, Okada T, Ogawa Y, Tateno C, Yoshizato K.
Author information
1PhoenixBio Co. Ltd, Hiroshima, Japan.
Abstract
We developed a nude rat model for determining the capacity of trichogenous cells to restore in vivo-damaged hair follicles (HFs). A surgical scalpel was inserted into the rat's dermis to generate the in vivo-damaged pelage HFs, the HFs whose lower parts were lost, but the upper parts containing sebaceous and bulge regions remained intact. Dermal papilla cells (DPCs) and dermal sheath cells (DSCs) from EGFP transgenic rat vibrissae were propagated in culture, and each alone (DPC or DSC) or a mixture (DPC/DSC) was transplanted into the intradermal path made by a scalpel. It was found that the in vivo-damaged HFs had hair self-restoration ability, and the transplanted trichogenic dermal cells prominently enhanced this ability, DPC/DSC transplants being more effective in enhancement than DPC or DSC alone. The restored bulbs contained EGFP-positive cells, shed their original straight shafts, generated new shafts, and further developed into hairs with a sebaceous gland and bulge structures by ~6 weeks post-transplantation. Compared to the preceding animal models, this model is less invasive, requires fewer donor cells and allows repeated operations with higher reproducibility and accuracy. The present study suggests that conditions causing in situ-damaged HFs, such as androgenic alopecia, in which HFs are damaged and miniaturized, can be restored by functional trichogenous dermal cell transplantation therapy. Copyright © 2015 John Wiley & Sons, Ltd.
Copyright © 2015 John Wiley & Sons, Ltd.

 

[voss224]

Nice, now all we need to do is wait 15 years for it to become available to the general public.

 

[benjt]

Two relevant questions here:

1) Does this also work in an Androgenetic Alopecia-struck environment? E.g. fibrotic tissue hindering regrowth, chronic inflammation permanently damaging cells and increasing the chances of scaring instead of proper healing, etc.

2) Does this also work in humans? Humans lack FGF9 and a few other things which mice have and which helps them regrow hair under circumstances which wouldn't allow a human to grow hair. This might be one of the cases where a mouse model is completely inappropriate.

 

[Armando Jose]

Two relevant questions here:

1) Does this also work in an Androgenetic Alopecia-struck environment? E.g. fibrotic tissue hindering regrowth, chronic inflammation permanently damaging cells and increasing the chances of scaring instead of proper healing, etc.

2) Does this also work in humans? Humans lack FGF9 and a few other things which mice have and which helps them regrow hair under circumstances which wouldn't allow a human to grow hair. This might be one of the cases where a mouse model is completely inappropriate.

http://www.ncbi.nlm.nih.gov/pubmed/23727932
http://www.uphs.upenn.edu/news/News_Releases/2013/06/cotsarelis/

It is real? Humans are diferent?

 

[hellouser]

This is really interesting considering that Replicel is using DSC cells. If combined with a hair transplant, you could potentially see growth in both donor AND recipient areas. Think of it this way;

You wound the donor area by extracting follicles with a punch via FUE and you create another wound but implanting follicles in the recipient area. You then inject DSC cells from Replicel and (hopefully) you get growth in recipient, donor and your transplanted donor hair in the recipient area. It would basically TRIPLE the amount of hair one could get out of a single hair transplant session.

Of course, this would be an ideal situation since.... well, im talking out of my ***. I think a LOT of men would opt for this right now if you told them YES its possible to have complete and FULL coverage without donor loss to hide the FUE scars. Even then, one could still opt for Pilofocus in the future to minimize scarring but the wound sites in the recipient area could still double up from the injected DSC cells.

 

[benjt]

http://www.ncbi.nlm.nih.gov/pubmed/23727932
http://www.uphs.upenn.edu/news/News_Releases/2013/06/cotsarelis/

It is real? Humans are diferent?

We do have FGF9, but in much too low concentrations. Your second link also clearly stated that.

 

[IDW2BB]

The injected DPC/DSC cells were propagated from the "whisker" hairs. I wonder about the characteristics of the new hairs.
Are they more corse than the otherwise native hair? Would this same procedure work using donor region hair?