Applied Biology MinoxiBoost For Minoxidil NonResponders

Lurker otto

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It didn’t work for me because I got side effects too fast and had to stop. I guess starting at like 0.5 mg and working your way up to higher doses would be safe. Now I’m doing other things to improve topical minoxidil efficacy.
What do you do to improve topical minoxidil efficacy?
 

mitcky

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Their site is shady and when I contacted them I recieved a lazy and sloppy reply. I'll probably still give their product a try, but based on the company itself, I'm not impressed.
At least you got a response----I didn't as of yet
 

-Synergy-

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What do you do to improve topical minoxidil efficacy?
Well right now I am using bakers p & s liquid because it exfoliates the sh*t out of the scalp. I swear I was getting results before with minoxidil and retinoic acid while routinely exfoliating. But I screwed up the first time and quit for dumb reasons. Now I am back at it hoping I can recreate the same positive response. If this isn’t good enough I will start light needling also. In addition, I might also make my skin damp before I apply the minoxidil. I will wait like 30 minutes or so after I’m done with a shower to apply. That’s three things I am thinking of to increase absorption or efficacy of anything topical.
 

-Synergy-

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fugged

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So this is supposed to help people even if they have the enzyme already? Or those who don’t? And is the enzyme itself available anyone know?
 

JaneyElizabeth

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So this is supposed to help people even if they have the enzyme already? Or those who don’t? And is the enzyme itself available anyone know?
I think it is more expensive than Loniten but certainly more than drinking topical.
 

-Synergy-

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I think it is supposed to help everyone. Otherwise minoxidil sulfate is too unstable and some people claim that you have to constantly keep remaking it.

I wonder if this contains phenolics
 

iCloud

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So Dhurat is involved with this, as with Follica.
 

fugged

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I read somewhere on something perfect hair health sent me that one of their clients is using something to that effect- where is it available??
 

iCloud

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Minoxiboost is still “coming in 2021” according to their website.. :rolleyes:
 

SciGuy29

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Funny, in the patent they do a good job of trying to hide what it could be by discussing various angles of attack that they could sulfonate.

I did find one part about Nrf2 (sulforaphane induces it) that I have a sneaky suspicion about:

In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising an inducer of the Nrf2 nuclear factor (encoded by the NFE2L2 gene) to a hair follicle cell and/or a keratinocyte cell, i.e., agents that increase the transcription of NFE2L2. Examples of inducers are 4-Hydroxyphenylacetic acid and acetylation via p300/CBP.

In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising an agent that disassociates Nrf2 from Keapl (Kelch-like ECH-associated protein 1) to a hair follicle cell and/or a keratinocyte cell. The agent can be selected to disassociate Nrf2 from Keapl by alkylation of Keapl, or some other process. Keapl, a repressor protein, binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway. Keapl binding and subsequent promotion of the ubiquitination is the major regulatory mechanism for Nrf2 controlled genes. An example of such an agent is 4-Octyl Itaconate.

In one embodiment, the invention concerns up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells by applying a composition comprising a direct or indirect inhibitor of Keap 1 (either a protein inhibitor (e.g., competitive/non-competitive inhibiter of Nrf2 binding) or an agent that reduces the transcription expression of Keap 1 mRNA) to a hair follicle cell and/or a keratinocyte cell. Examples of direct inhibitors are mir-200a, RTA 408, and LH601A.
 

Nebula74

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-Synergy-

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The official website for Applied Biology => https://www.appliedbiology.com/index.html

R & D Pipeline => https://www.appliedbiology.com/AppliedBiologyPipeline.html#!

Applied Biology is headquartered in California

California Secretary of State business entity search comes back legit when you search for Applied Biology => https://bizfileonline.sos.ca.gov/search/business

When you take a closer look at the information included in the link above, it seems that the company might be going through some kind of a merger.

Maybe it is all bs or COVID took their company under.
 

Nebula74

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The official website for Applied Biology => https://www.appliedbiology.com/index.html

R & D Pipeline => https://www.appliedbiology.com/AppliedBiologyPipeline.html#!

Applied Biology is headquartered in California

California Secretary of State business entity search comes back legit when you search for Applied Biology => https://bizfileonline.sos.ca.gov/search/business

When you take a closer look at the information included in the link above, it seems that the company might be going through some kind of a merger.

Maybe it is all bs or COVID took their company under.
Yes I hope they are legit but this sh*t was thought to be coming out when I first joined this forum, still no development in like a year and a half, this would be a massive win for me if they released it
 
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