squeegee
Banned
- Reaction score
- 132
Potential mechanisms by which androgens could
increase BP. Androgens could upregulate cytochrome P450 4A
-hydroxylases, which would increase 20-HETE levels. 20-HETE
would activate NF-
B, which would activate NADPH oxidase to
increase production of reactive oxygen species (ROS) and
decrease NO bioavailability. The reduction in NO would increase
renal vasoconstriction, leading to hypertension
http://hyper.ahajournals.org/content/57/4/681.full.pdf
increase BP. Androgens could upregulate cytochrome P450 4A
-hydroxylases, which would increase 20-HETE levels. 20-HETE
would activate NF-
B, which would activate NADPH oxidase to
increase production of reactive oxygen species (ROS) and
decrease NO bioavailability. The reduction in NO would increase
renal vasoconstriction, leading to hypertension
http://hyper.ahajournals.org/content/57/4/681.full.pdf