Androgen Action on Human Skin – From Basic Research to Clinical Sigcance

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Androgen action on human skin – from
basic research to clinical significance

http://www.klinikum-dessau.de/fileadmin/user_upload/Hautklinik/PDF-Files/244_expder-androgens.pdf

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. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogenbiosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in eitherincreased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sexsteroid hormone and in growth or differentiation. The gene expresses two transcript variants. (provided by RefSeq, Jul2008)

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[h=1]Prostaglandin D[SUB]2[/SUB] Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia[/h]However, cytochrome P450s also have roles in eicosanoid biology, and they may alter prostaglandin metabolism (40). Thus, altered prostaglandin metabolism might contribute to more than one type of human alopecia, although additional studies are needed.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/