IvanXproject
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I recently came across something that I found very interesting. Credit to "klijom" for writing this/ spreading this information:
"3a hsd is a natural enzyme present within the muscular structure of the body which prevents the conversion of testosterone to dht wherever it is present. Now to me it would seem that introducing an enzyme to the scalp (3a hsd) should in theory be a lot easier than trying to remove an enzyme from the scalp (5ar). I honestly am starting to believe this is a massive avenue which has been completely ignored and I don't see why (ethics aside) 3a hsd supplements for the scalp could not be created to "neutralize" dht as soon as they interact (as they do in the muscles).
Also it seems that many of the "hair loss fads" that we hear about e.g. coconut oil, olive oil etc. may actually be increasing 3a hsd activity (in however small effect). Now if this effect can be harnessed and magnified which may be a lot easier than most of the other methods being developed at the moment (follica, histogen, etc.) then we will have something that although not a cure but would be atleast a permanent topical (worst case scenario oral) treatment. The link of 3a hsd and prostate cancer again seems to solidify this claim as this is the exact route that propecia and 5ar inhibition came from.
Also check this out, isoretinoin, better known as accutane is a drug infamous for causing hair loss. The reason? Isotretinoin causes upregulation of D2 receptors. Upregulating D2 receptors is bound to lead to hair loss (see Dr. Costarelis). Another side effect of isoretinoin? IT INHIBITS 3A HSD ACTIVITY...! It's clear that the antimatter to 5ar is indeed 3a hsd, and if we can make propecia to block 5 ar, then we SURE AS HELL can create something to magnify 3a hsd activity. It is my understanding that formulating a topical treatment is a million times easier when you are trying to boost a function rather than when you inhibit a function (hence the difficulties in formulating a topical propecia). There also seems to be a recently formed team in Israel called Technion who have also identified 3a hsd as the main culprit.
The best chance of a cure coming out is if someone thakes 3a hsd seriously and finds a way to introduce it to the scalp. If I had any sort of background in biomedical science I would be working on it right now as it does not seem too difficult to introduce enzymes to the scalp (no chance of rejection if enzymes developed are taken from your own body), and virtually no chance of mutation (cancer)."
So what do you guys think? Is this guy onto something here?
"3a hsd is a natural enzyme present within the muscular structure of the body which prevents the conversion of testosterone to dht wherever it is present. Now to me it would seem that introducing an enzyme to the scalp (3a hsd) should in theory be a lot easier than trying to remove an enzyme from the scalp (5ar). I honestly am starting to believe this is a massive avenue which has been completely ignored and I don't see why (ethics aside) 3a hsd supplements for the scalp could not be created to "neutralize" dht as soon as they interact (as they do in the muscles).
Also it seems that many of the "hair loss fads" that we hear about e.g. coconut oil, olive oil etc. may actually be increasing 3a hsd activity (in however small effect). Now if this effect can be harnessed and magnified which may be a lot easier than most of the other methods being developed at the moment (follica, histogen, etc.) then we will have something that although not a cure but would be atleast a permanent topical (worst case scenario oral) treatment. The link of 3a hsd and prostate cancer again seems to solidify this claim as this is the exact route that propecia and 5ar inhibition came from.
Also check this out, isoretinoin, better known as accutane is a drug infamous for causing hair loss. The reason? Isotretinoin causes upregulation of D2 receptors. Upregulating D2 receptors is bound to lead to hair loss (see Dr. Costarelis). Another side effect of isoretinoin? IT INHIBITS 3A HSD ACTIVITY...! It's clear that the antimatter to 5ar is indeed 3a hsd, and if we can make propecia to block 5 ar, then we SURE AS HELL can create something to magnify 3a hsd activity. It is my understanding that formulating a topical treatment is a million times easier when you are trying to boost a function rather than when you inhibit a function (hence the difficulties in formulating a topical propecia). There also seems to be a recently formed team in Israel called Technion who have also identified 3a hsd as the main culprit.
The best chance of a cure coming out is if someone thakes 3a hsd seriously and finds a way to introduce it to the scalp. If I had any sort of background in biomedical science I would be working on it right now as it does not seem too difficult to introduce enzymes to the scalp (no chance of rejection if enzymes developed are taken from your own body), and virtually no chance of mutation (cancer)."
So what do you guys think? Is this guy onto something here?