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Revivogen Consumer
Interview
The creators of Revivogen field questions from our users, and give
honest answers in this consumer-lead interview.
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We asked our users to put together any questions they had for the makers
of Revivogen, and the result is this robust FAQ on the product. This interview
is in its purest form, as none of the questions were modified or censored
before sending to Revivogen for an answer. We appreciate Dr. Shargani
putting himself on the line and dedicating such an extensive amount of
time to answering so many blunt, elaborate questions.
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Can Revivogen be used in conjunction with Rogaine
or other Minoxidil containing topicals? |
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As far as I know the hair problem is NOT about
hair loss, BUT about lack of hair growth. Why should
I use my money on Revivogen if it only reduces hair
loss rate to a normal level, and only "a smaller percentage"
report regrowth? |
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Propecia protects the hair follicle. If you
take it, at least your follicles will live long enough
to see the next wonder drug. Products such as Minoxidil
only force the dying follicle to try to keep producing
hair. End result on Propecia is a healthy follicle as
long as Propecia is around. End result on Minoxidil
is a dying follicle on life support. Can you comment
on this, and on which side of the fence Revivogen falls?
Is it simply coercing the follicle into activity, or
is it actually protecting the follicle from further
damage? |
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Do I need a doctor's permission to obtain Revivogen? |
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You stated that while a significant number
of your users experienced a significant decrease of
fallout and an increase in thickness, a smaller percentage
of your users had reported visual growth of baby fine
hairs throughout the scalp including the frontal area.
How much is a smaller percentage? |
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Have you seen any instances of "shedding" with
Revivogen? |
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Can you disclose the concentrations of ingredients
in your products? |
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You recommend applying Revivogen once daily.
Is this sufficient to cause maximum beneficial effects? |
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Your product contains Niacin which stimulates
blood flow and hence leads to temporary redness where
applied. Would this be overtly noticeable if it were
applied during the day in the workplace? |
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Does your research indicate how much the Revivogen
Shampoo contributes to the products effectiveness. |
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Ingredients used topically do get absorbed
into the bloodstream don't they? and even though the
product is natural, could the product still cause unwanted
side effects like pain in the testicles, enlarged breasts
or any other unwanted side effects? |
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The very fact that you would produce a topical
DHT inhibitor implies that you don't feel that blood
levels of DHT are significant in balding. Can you justify
this point of view or provide evidence to support it? |
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Do you have any proof of which type(s) of 5
alpha reductase (type 1 or type 2, or both) are inhibited
by the fatty acids in your product? |
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Do you have any proof of which type(s) of 5
alpha reductase (type 1 or type 2, or both) are inhibited
by the Azelaic Acid in your product? |
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Has it been tested on human subjects to determine
if it's non irritating? |
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Has it been tested on human subjects to determine
its level of DHT suppression? |
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What results could a typical responder expect
vs. those of an "ideal" responder, like those
in the photographs you have published from your preliminary
trials? |
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For any of your customers who have had success
with the product, will you allow us to talk to them,
by invitation? |
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Was your product scrutinized under independent
clinical trials, and if so, what were the results? |
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How long has Revivogen been around,
and how successful has it been for those who have used
it? Can it grow hair on the front as well as on the
crown? |
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I'm responding very well to 1/4 tablet
of Propecia daily, but I haven't responded to topicals
at all. I don't see how a topical can be as good as
a drug. How could Revivogen be as effective as Propecia? |
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Is Revivogen effective for regrowth
at the hairline? |
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Q: Can Revivogen be used in conjunction with
Rogaine or other Minoxidil containing topicals?
A: Yes and it makes sense too. Revivogen
is a DHT inhibitor and Minoxidil is a hair growth stimulator. We have
heard many positive comments from people who use both products as well
as those who were using Minoxidil before using Revivogen However the products
must be applied at least three hours apart to prevent any absorption interference.
Q: As far as I know the hair problem is NOT
about hair loss, BUT about lack of hair growth. Why should I use my money
on Revivogen if it only reduces hair loss rate to a normal level, and
only "a smaller percentage" report regrowth?
A: The problem in hair loss is not lack of
hair regrowth. It is shortening of the anagen phase and miniaturization
of the hair follicle due to DHT. Revivogen works very similar to Propecia
by reducing DHT production. Therefore, you can expect similar results
without the potential side effects. However not everyone responds to Propecia
or Rogaine which is also true with Revivogen
Q: Propecia protects the hair follicle. If
you take it, at least your follicles will live long enough to see the
next wonder drug. Products such as Minoxidil only force the dying follicle
to try to keep producing hair. End result on Propecia is a healthy follicle
as long as Propecia is around. End result on Minoxidil is a dying follicle
on life support. Can you comment on this, and on which side of the fence
Revivogen falls? Is it simply coercing the follicle into activity, or
is it actually protecting the follicle from further damage?
A: At this time Revivogen is very similar
to finasteride in regards to mode of action i.e. inhibiting 5 AR types
I and II. It also contains ingredients that prevent DHT's attachment to
the androgen receptors. Your statement about the benefits of Rogaine and
Propecia is not entirely correct and we can not tell you exactly which
one of these scenarios apply to Revivogen We believe that all of these
products can perform these functions to some extent but you are welcome
to make your own assessment based on these facts.
Q: Do I need a doctor's permission to obtain
Revivogen?
A: No. Revivogen is a natural product and
as doesn't need a prescription
Q: You stated that while a significant number
of your users experienced a significant decrease of fallout and an increase
in thickness, a smaller percentage of your users had reported visual growth
of baby fine hairs throughout the scalp including the frontal area. How
much is a smaller percentage?
A: The data we have was not statistically
significant. We will be able to provide additional information with the
completion of the clinical trial.
Q: Have you seen any instances of "shedding"
with Revivogen?
A: It seems that many topicals put the user
through phases where heavy loss is possible.
Q: Can you disclose the concentrations of
ingredients in your products?
A: Due to patent pending status of Revivogen
we can't disclose these details at this time.
Q: You recommend applying Revivogen once
daily. Is this sufficient to cause maximum beneficial effects?
A: In our own internal study we have seen
adequate results while using Revivogen once daily. Also once daily applying
has shown to increase compliance which is a very important factor in achieving
results. After all continuous use is the most important factor for achieving
results. However applying Revivogen more than once can have increased
efficacy in some individuals and may in fact be necessary for certain
individuals.
Q: Your product contains Niacin which stimulates
blood flow and hence leads to temporary redness where applied. Would this
be overtly noticeable if it were applied during the day in the workplace?
A: Generally the redness of Niacin last about
half an hour to 1 hour and it is generally unnoticeable by most individuals.
Also we have recently reduced the Niacin content of the formula so it
can be easily used by those with sensitive skin.
Q: Does your research indicate how much the
Revivogen Shampoo contributes to the products effectiveness.
A: Revivogen shampoo has the same active
ingredients found in the Scalp Therapy formula. It can only enhance the
effectiveness of the formula and it is not effective when used alone.
The reason is that any shampoo regardless of brand or active ingredients
can not effectively deliver its active ingredients to the hair follicle
due to the short amount of time it remains on the scalp.
Q: Ingredients used topically do get absorbed
into the bloodstream don't they? and even though the product is natural,
could the product still cause unwanted side effects like pain in the testicles,
enlarged breasts or any other unwanted side effects?
A: All active ingredients can get absorbed
into the blood stream but at a extremely low concentrations. There is
long history of using these ingredients both orally and topically at much
higher doses without any side-effects. It is only when these ingredients
are applied locally at a high concentration that they can have antiandrogenic
effects which is why oral supplements of these ingredients can't work
as well.
Q: The very fact that you would produce a
topical DHT inhibitor implies that you don't feel that blood levels of
DHT are significant in balding. Can you justify this point of view or
provide evidence to support it?
A: The blood levels of DHT may play a minor
role in Androgenetic Alopecia but it is the locally produced DHT which
plays the major role. If you look at any physiology text book (such as
Guyton's Medical Physiology) you can see that the majority of DHT production
takes place at the site where it exerts its effects. Also there is a high
concentration of type 2 isoenzyme within the hair follicle itself and
a higher concentration of the type 1 form within the scalp and sebaceous
glands which feed into the hair follicle. Together they can produce more
DHT locally than what blood brings to the hair follicle. Also most researchers
now believe that it is the locally produced DHT that is involved in Androgenetic
Alopecia rather than the circulatory DHT. Finally there is new evidence
about effectiveness of topical inhibition of DHT on hair growth by Dr.
Christiano which provides support for this theory.
Q: Do you have any proof of which type(s)
of 5 alpha reductase (type 1 or type 2, or both) are inhibited by the
fatty acids in your product?
A: The studies done on these fatty acids
indicates that they inhibit both types 1 and 2 forms of 5AR equally from
90% to 98%. The complete abstract of these studies can be viewed on our
web site.
Q: Do you have any proof of which type(s)
of 5 alpha reductase (type 1 or type 2, or both) are inhibited by the
Azelaic Acid in your product?
A: We are unaware of any studies describing
which type of 5AR is inhibited by Azelaic acid.
Q: Has it been tested on human subjects to
determine if it's non irritating?
A: Yes. On the internal studies we noted
mild scalp irritation in less than 2% of the subjects which was temporary
and self limiting. The irritation was mainly due to Niacin which is an
irritant and causes vasodilatation which helps in absorption.
Q: Has it been tested on human subjects to
determine its level of DHT suppression?
A: The original studies on the inhibition
rate of 5AR by the main active ingredients were performed in vivo (on
live non human subjects) as well as in vitro (in the test tube) which
has proven that DHT production is inhibited by these ingredients up to
98%. Some of the testing such as Saw Palmetto studies also involved human
subjects which have shown very good results.
Q: What results could a typical responder
expect vs. those of an "ideal" responder, like those in the
photographs you have published from your preliminary trials?
A: In general there is a significant decrease
in hair loss and re-thickening of baby fine hairs within 3 to 6 months
of use. The improvement continues with use and ultimately the results
depend on many factors including the degree of hair loss, the length of
time since the hairs have fallen, and age.
Q: For any of your customers who have had
success with the product, will you allow us to talk to them, by invitation?
A: We place a very high value on our customers
privacy and we can not release that information to anyone. However many
of our clients can eventually be found in news groups such as alt.baldspot
or HairlossTalk chat room.
Q: Was your product scrutinized under independent
clinical trials, and if so, what were the results?
A: We are currently working on such a study
so we can better evaluate Revivogen's effectiveness. However as mentioned,
earlier independent research on topical application of GLA and Saw Palmetto
Extract has shown very positive effects on hair growth.
Q: How long has Revivogen been around,
and how successful has it been for those who have used it? Can it grow
hair on the front as well as on the crown?
A: We have been experimenting with formula
for the past three years and the product was officially introduced on
October of 1999. So far the majority of customers have reported significant
decrease of hair loss and increased in thickness of the baby fine hair
and existing hair. A smaller percentage of users have reported visual
growth of baby fine hairs all over the scalp including the frontal area.
So far this is very much in line with what we observed in our clinical
study.
Q: I'm responding very well to 1/4
tablet of Propecia daily, but I haven't responded to topicals at all.
I don't see how a topical can be as good as a drug. How could Revivogen
be as effective as Propecia?
A: Propecia is the first FDA approved medication
that targets the main source of hair loss DHT by inhibiting 5-alpha-reductase
the enzyme that converts Testosterone to DHT. Propecia only inhibits type
2 form of the enzyme up to 70%. Revivogen works through the same mechanism
but can be applied topically. The main active ingredients of Revivogen
GLA, ALA and Linoleic Acid have been clinically proven to block both type
1 and 2 forms of 5AR EQUALLY up to 98% when applied topically. In addition
Saw Palmetto Extract which is also used in the Revivogen formula has been
proven to mainly act by blocking the attachment of DHT to its receptors
on the hair follicle regardless of the enzyme type which produces it.
Q: Is Revivogen effective for regrowth
at the hairline?
A: We have seen very good results with the
hair line in general but we can not claim that Revivogen prevents hair
loss, grows hair, or regrows hair. This is due to FDA regulations that
considers any product making such claims as a New Drug (even if the ingredients
are natural) and requires FDA testing and approval which can take 7-10
years and millions of dollars to complete. Also results vary from person
to person and depend on many factors including the degree of hair loss,
the length of time the hair loss has occurred and age which is also true
for Rogaine and Propecia.
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