A natural DHT inhibiting formula, Crinagen
has been shown to stop hair loss and promote regrowth. Crinagen uses natural
substances as its active components. It is intended to offer users a natural
alternative to the synthetic chemical treatments (such as minoxidil).
Crinagen is in the class of clinically efficacious yet unproven treatments.
Along with Revivogen and Folligen, Crinagen should be considered only
after making use of the proven treatments.
What is Crinagen?
Crinagen is a completely natural topical scalp preparation. Its
natural ingredients perform two basic functions: they decrease the production
of a potent male hormone associated with male-pattern hair loss (DHT),
and affect the blood vessels that nourish follicles in the scalp. One
of the unique aspects of this treatment is that it does not have just
one active ingredient; it has many. These ingredients act together to
help block factors that are detrimental to growth.
Who is this
Treatment for?
Crinagen is for both men and women, and can either be used alone,
or with other follicle stimulators such as Minoxidil, and DHT inhibitors
like Propecia. Crinagen is compatible with these products and helps reduce
the scalp irritation is sometimes caused by them.
What is it
used for?
Crinagen is a topical DHT inhibitor, so in men, it is primarily
used for the same purpose that Propecia is used: Long term maintenance
and cessation of fallout. If you use Crinagen, please set your expectations
accordingly. This treatment also has some growth stimulating properties,
however it is suggested you use Minoxidil or Tricomin in combination with
it, if this is your goal.
Crinagen's
Method of Action
DHT continues to damage and miniaturize follicles.
As follicles are continually damaged by the ongoing effects of dihydrotestosterone,
the body responds to this injury with an inflammatory response which is
primarily mediated by the immune system. The cells of the immune system
cause inflammatory reactions which further damage these follicles and
eventually destroy them.
The best way to stop the progression of androgenic Alopecia is to correct
the underlying genetic defect that causes it. Unfortunately, gene therapy
is not yet possible. The next best solution is to block the formation
of dihydrotestosterone. Most researchers believe that this hormone is
responsible for the progressive miniaturization of follicles, which is
the hallmark of androgenic Alopecia. One of the actions of Crinagen is
to block the activity of 5 alpha-reductase and, thereby, its ability to
convert testosterone into dihydrotestosterone. In this manner, it reduces
the amount of DHT within the scalp. Reducing the amount of DHT reduces
its miniaturizing effects on the follicle.
It also reduces the amount of injury it causes to the follicle and also
the extent of the immune response targeted to the follicle. The creators
of this product recommend the use of immunosuppressant agents in conjunction
because, although it may reduce the quantity of DHT, it does not completely
reverse the damage to follicles that has already occurred. These damaged
follicles incite an immune system inflammatory response which can damage
them even further. The use of immunosuppressants can reduce this inflammatory
reaction and, thus, subsequent damage to follicles.
What's in
it?
The ingredients are: Distilled water; Polysorbate 20; Azelaic Acid; Zinc
acetate hydrate; Niacin; Vitamin B6 (as Pyridoxal-5-phosphate); Saw palmetto
extract (serenoa repens); Ginkgo biloba and a mild natural fragrance.
The two most powerful ingredients of are Zinc and Saw Palmetto. Both agents
have been shown to block the conversion of male sex hormones (such as
testosterone) into dihydrotestosterone (DHT). Dihydrotestosterone is a
potent hormone. Most researchers believe it is responsible for male-pattern
baldness. The ingredients accomplish this by blocking the enzyme 5 alpha-reductase,
which is required to produce dihydrotestosterone. Since the ingredients
are all natural ones, there are no hormonal side effects. The hallmark
of male-pattern baldness is the progressive miniaturization of follicles.
This is caused by a genetic predisposition of individual follicles that
renders them more sensitive to normal circulating levels of male sex hormones.
This is because increased levels of 5 alpha-reductase in these follicles
causes the conversion of male hormones (such as testosterone) into dihydrotestosterone.
Crinagen Side
effects
There are no known side effects.
Hints and
Tips
Crinagen differs from other topical scalp preparations in that it is sold
by itself, without an accompanying shampoo. This means it is much much
cheaper than most similar treatment packages out there. Effective shampoos
already exist and are easy to obtain. I would recommend ones that are
anti-inflammatory, such as Nizoral which is available in 1% form in every
Grocery Store shampoo section. There is also a 2% form available by prescription
which has shown results on balding similar to 2% minoxidil, but in any
case, we have heard nothing but good reports about Nizoral shampoo. It
is a very effective immunosuppressant.
To prevent the inflammatory reaction to the scalp from occurring , the
source of damage to the follicles must be eliminated. Again, DHT is the
source of this injury, causing the progressive miniaturization of follicles.
It contains both Zinc and Saw Palmetto, which reduce the production of
DHT. In addition, it contains vitamin B6, which has been shown to work
in concert with zinc to inhibit 5 alpha-reductase.
